THANZ

THANZ council dinner with international guests @Blood2025

Blood-ISBT 2025 is in full swing in Perth, WA. This morning here is Prof. Jean Connors on options to prevent and control bleeding on new FXI inhibitor anticoagulants #Blood2025 #THANZ

What a great plenary lecture of Leslie Raffini at #ISTH2025 Pediatric Thrombosis: a lot has been done in 30 years, but still a lot to be done in the coming years!

Observational data (n=506) demonstrating superior safety and efficacy of low dose apixaban compared to VKA in cirrhotic PVT. Even Child C cirrhosis was represented. #ISTH2025 @THANZBlood

👏 A truly encouraging session today at the #ISTHCongress on the ISTH haemophilia guidelines. The open and constructive dialogue reflects the progress we’ve made collectively as a global community. This evolving landscape highlights the value of ongoing collaboration and mutual respect among all stakeholders.

@THANZBlood are thrilled that Jean will be one of our keynote speakers at our national Blood conference in Perth in October! Looking forward to it! #ISTH2025 #Blood2025

Sustained and stable FIX levels have now been repeatedly been observed across multiple #genetherapy clinical trials for #hemophila B. Will extend the red line tomorrow at Clinical Gene Therapy session at #ISTH2025.

@MSkinnerDC highlighting the danger of over-reliance on RCTs during guideline development for rare conditions like haemophilia #ISTH2025 @THANZBlood

Critical appraisal of the ISTH Haemophilia Guidelines session, with some robust discussion and interesting perspectives, our very own Dr Jane Mason delivering a great presentation “Dissecting the Guidelines” the clinician experience #ISTH2025 @THANZBlood

#ISTH2025!! Thanks @AnticoagForum /@isth for allowing me to launch our Anticoagulation Stewardship Periop Survey/present my ICU intervention poster, @THANZBlood for the travel grant to get me here + @LanaCastellucci @acforum_darren @GBarnesMD Jean Connors, Vivien Chen @JonPenm ❤️

Biology resists simplicity #ISTH2025 plenary session. @THANZBlood

Promising phase1/2 data on NXT007 prophylaxis presented by Midori Shima at #ISTH2025. Can we achieve “normal range” FVIII equivalence? We look forward to phase 3 studies and further data around ADA risk.

@evsfaustino beautiful summary of 2-hit hypothesis for CVC related VTE in critically ill kids, role of inflammation, need to decouple hemostasis from thrombosis, potential role for XI / XIIa inhibitors, and maybe adolescents aren’t just young adults… #ISTH2025 @THANZBlood

Is this the end of rivaroxaban for acute VTE? @LanaCastellucci presenting the COBBRA trial - 1st RCT comparing apixaban to riva over 3 months. 56% reduction in bleeding risk with apixaban. A safer Rx with the same efficacy. #ISTH2025

@THANZBlood Congratulations @LanaCastellucci and the entire study team ! Incredible work on this pivotal trial !

Dr Uma Athale gave an excellent SOA update on thromboprophylaxis in pediatric cancer ?who, when, with what and for how long…more questions than answers right now! Work to be done #ISTH2025 @THANZBlood

Late breaking abstract session at #ISTH2025. COBRRA results are in! 50% reduction in bleeding with Apixaban use for acute VTE compared to Rivaroxaban. @THANZBlood members were co-investigators on this study, an enormous effort.

A fitting tribute to the life’s work of Claire McLintock delivered in the Claire McLintock Memorial Lecture by Jennifer Curnow. Congratulations Jennifer, @THANZBlood is proud of you! #ISTH2025

The #ISTH2025 Opening ceremony is under way! @IsthPresident is giving opening remarks on the importance of global collaboration and knowledge exchange:

@DeniseSabatino2 highlighted the challenges of AAV integration studies in a great talk at #ISTH2025