Tony Montgomery

Where Do Ideas Come From? open.substack.com/pub/tmontjr/p/…

New publication: Exercise is not a single-pathway intervention for mental health. This review synthesizes evidence showing that exercise reshapes brain–body systems with benefits depending on dose and recovery, not just intensity. 🔗 doi.org/10.1016/j.jpsy…

God Is Dead and We Replaced Him with the Self open.substack.com/pub/tmontjr/p/…

When Did Personal Responsibility Become an Attack Instead of a Way of Life? open.substack.com/pub/tmontjr/p/…

The Crisis of Meaning Is Deeper Than We Admit open.substack.com/pub/tmontjr/p/…

New article published @psychedelic_org and @ResearchGate, Psychedelic Rejuvenation Hypothesis A Framework for Cellular and Psychological Restoration: researchgate.net/publication/39…

@Dr_JoJoShields Congratulations!!

Excited to share our latest work! I am extremely grateful and proud of our team for their efforts on seeing this through.

New preprint: The Psychedelic Rejuvenation Hypothesis Can psychedelics act as preventive medicine, not just therapy by restoring cellular + psychological youthfulness? From mitochondria to mindset, this framework explores how psychedelics may slow aging + extend healthspan. 🔗doi.org/10.31124/advan… #Psychedelics #Longevity #Neuroplasticity

Exercise is more than movement, it’s medicine for the brain. Our new paper breaks down how exercise improves mental health at the neurobiological level. doi.org/10.31124/advan…

Avoidance feels like relief, but it’s the fuel for anxiety. Every time you avoid, you teach your brain the fear is real, block corrective learning, shrink your world, and reinforce the cycle. Facing fears, not fleeing them, is a tool that can break anxiety.

Beyond Strength: The Psychology of Drive and Coaching w/ Paul Oneid open.spotify.com/episode/3bAfV9…

Psychedelics may be like exercise for your brain. Not recreational, not just therapeutic but voluntary, challenging stimuli that trigger neuroplasticity, just like weights trigger muscle growth. The key? You choose the stress. That’s what makes it healing. #psychedelics #BDNF #resilience

3.Even acetylcholine receptors—critical for focus and movement—become more responsive with regular training. 4.Medications flood the system. Exercise teaches the brain to use its own chemistry more efficiently.

2.Exercise restores receptor sensitivity: •Dopamine: ↑ D2 receptor density → motivation, drive •Serotonin: ↑ 5-HT1A → mood regulation •GABA: ↑ GABA-A function → anxiety reduction •Glutamate: balanced NMDA/AMPA → learning without overload

Neurotransmitters are only half the story. The real change comes from how your brain responds to them. That’s receptor sensitivity—and exercise rewires it. A thread on how physical activity recalibrates your brain’s chemistry: 🧵

@alieninsect Really enjoyed this book and your other ones!

“His conclusions are astonishing… And to some they will be horrifying. This book is not to be missed." — Dennis McKenna, PhD DEATH BY ASTONISHMENT: Confronting the Mystery of the World’s Strangest Drug. (St. Martin’s Press, Macmillan). OUT NOW

Exercise improves mental health, so why don’t more people do it? -Depression impairs motivation -65% quit exercise in 6 months -Stigma = shame, avoidance, dropout We need to go beyond “just exercise” and build motivational techniques ground in researched interventions, but yet we mostly focus on mechanisms of action rather than the human experience. #MentalHealth #ExerciseScience #Stigma #SelfDeterminationTheory #PublicHealth #BehaviorChange

SSRIs Can Cause Severe Mitochondrial Dysfunction Installment eight in our series on understanding the truth about SSRIs. 🧵