Tae Gun Kang, PhD

Trained immunity responses across infectious diseases and cancer vaccines dlvr.it/TRqvG8 #immunology

New Online! Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target dlvr.it/TRknlS

Online now: Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration dlvr.it/TRksl2

Multiple recent papers (two just this week) highlighting the role of inflammation in sculpting “epigenetic memory” and promoting tumorigenesis across various solid organs. science.org/doi/10.1126/sc… nature.com/articles/s4158… science.org/doi/10.1126/sc… cell.com/developmental-…

Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation go.nature.com/40Q3r1d

New research leveraging patient data and mouse models in Science reveals how psychological stress can worsen atopic dermatitis, or eczema. It does so by activating a specific neural pathway that links the brain to immune responses in the skin. The study’s authors emphasize that managing psychological stress, alongside conventional therapies, may represent an underused but potentially powerful strategy for improving outcomes in eczema. 📄: scim.ag/4stkUsf #SciencePerspective: scim.ag/4uMy59i

St. Jude scientists leveraged findings about how cancer cells reduce the effectiveness of immunotherapy to suggest a combination treatment to reduce leukemia relapse. Read more: ow.ly/VhTj50V69eE

An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: scim.ag/3OJP6gJ

In a new Science study, researchers undertook a reverse-translation approach to investigate the molecular mechanisms regulating the durability of #Tcell responsiveness to checkpoint blockade immunotherapy. 📃: bit.ly/4dQ5TJ9 #SciencePerspective: bit.ly/4dITlTD

New research shows that disrupting the Asxl1 gene in T cells boosts response to immunotherapy and improves long-term tumor control by preventing T-cell exhaustion. Targeting Asxl1 may lead to more effective T cell-based immunotherapies. ow.ly/QbIg50TJeVq

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses dlvr.it/TDG8Cr

Online now: Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma dlvr.it/TDGcvv

Now online! Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy dlvr.it/TDF4WJ

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation dlvr.it/TD92S6

In case you missed it: Sophie Guelfi (@guelfi_sophie), Kairbaan Hodivala-Dilke (@Hodivala_Dilke) and Gabriele Bergers (@BergersLab) discuss possibilities to target the #TumourVasculature as part of combination therapies. go.nature.com/4dROuQW

We are excited to announce our $325 million #SeriesC financing. This new investment will enable ArsenalBio's ongoing development efforts and scale our manufacturing capabilities to develop T-cell medicines. We thank the new investors along with our existing investors for their support in helping us to achieve our goal to defeat cancer. #celltherapy #patientsfirst arsenalbio.com/2024/09/04/ars…

Nature research paper: Fate induction in CD8 CAR T cells through asymmetric cell division go.nature.com/4g6YAyU

In the latest issue! Memory B cell fitness and anergy has significant links to cancer lethality dlvr.it/TCPZpl