TracyLab

Thrilled our work on KIBRA, plasticity, and memory loss in tauopathy was published today @jclinicalinvest. Congrats to Grant Kauwe @KAPNavarro, and collaborators @kbcasaletto @LiGanLab @birgits61642917 @grinberg_t , Joel Kramer, Bill Seeley, Todd Sacktor jci.org/articles/view/…

New mechanism for how synapses deteriorate in #Alzheimers, with new tool that maps dynamic postsynaptic changes after acute tau oligomer exposure. Study in @MolNeuro shows oligomers trigger progressive synapse decline in human neurons. @TaraTracyLab. buckinstitute.org/news/discovery…

🧠New preprint! How does pathogenic #tau impair #synaptic plasticity leading to memory loss in #tauopathy? Our study suggests that FTLD-tau inhibits protein synthesis required for plasticity by disrupting the function of eIF4B. Thank you to collaborators! biorxiv.org/content/10.110…

Proud of our Buck colleagues who stood up for science at the Stand Up For Science rally in SF today! They joined hundreds of people including other colleagues from Stanford, UC Berkeley, UCSF, NASA, & EPA. The rally was one of 32 events across the U.S. today. #standupforscience

Dr. MichelleArkin from @UCSF, Distinguished Professor in Pharmaceutical Chemistry, was invited by BWISE to give a seminar today. She talked about designing compounds to inhibit Caspase 6 activity to reduce tau toxicity in Alzheimer's disease.

Male-female comparisons are powerful in biomedical research. Unraveling and harnessing mechanistic etiologies of sex differences may reveal new diagnostics and therapeutics for the aging brain. More from us in the latest @NeuroCellPress issue on aging. @BBParis1984 @ctmurphy1 @YousinSuh @SCAgingBrain authors.elsevier.com/a/1kPEa3BtfH9B…

Excited to share our work, new in @ScienceMagazine: science.org/doi/10.1126/sc…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)

Check out this new paper in @CellReports from the Palop lab. 📄 bit.ly/3Vat2zc

Early risers in lab were treated to a beautiful rainbow today at @BuckInstitute ! Photo credit: @KAPNavarro

Representing the Tracy lab at #sfn2024, Lei Yao is presenting on KIBRA and synapse repair (Poster# B99) and Doyle Lokitiyakul is presenting on eIF4B and synaptic plasticity (Poster# A59) both on Sunday 10/6 @ 1-5pm. It's going to be a good session!

Had a karaoke extravaganza in the Tracy lab this summer. We have quite impressive musical talents in the group!

I'm excited to share 2 of our new studies now out as preprints on BioRxiv! biorxiv.org/content/10.110… biorxiv.org/content/10.110… From @wysscoray lab in collaboration with many amazing groups including... 1/5

Astrocytes, brain cells that support and regulate neurons, contribute to sex-specific brain mechanisms in preclinical models, says a team led by Drs. Anna and Adam Orr of @WCM_BMRI. Findings may aid understanding of neurological conditions. bit.ly/3UUQ9gg

Way to go to our two recent poster award winners! 🌟Doyle Lokitiyakul winner at the Bay Area Aging Meeting at UC Berkeley and 🌟Ivy Wong winner at the Buck Student Aging Symposium.

Insightful interview of our very own Dr. Mahima Sharma in eNeuro!

Congrats to Dr. Lei Yao in the lab who received a Hillblom Foundation postdoctoral fellowship and is making exciting progress on a KIBRA therapeutic! llhf.org/portfolio/lei-…

Thrilled to announce our latest work in @CellCellPress! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/… (1/5)

So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort! nature.com/articles/s4158… #TeamMassSpec #Proteomics #GPCR

We’re so proud (and not surprised) that our own Tara Tracy is among the @SFBusinessTimes Next Generation of Biotech Superstars in the Bay Area. @TaraTracyLab is focused on treating memory loss in #Alzheimers by repairing synapse function. Go Tara! bizjournals.com/sanfrancisco/n…

Meet Christina King, recently named a “rising star’ by @JProteomeRes. The associate director of Buck’s #MassSpectrometry Center and #Proteomics Core talks about her work and the factors that led her to becoming a “instrument geek” in our latest blog post buckinstitute.org/blog/meet-buck…

Both honored and sad to share obituary for Judy Campisi @Nature. Many thanks to Jan Vijg and Jan Hoeijmakers for recounting Judy’s pioneering work in cellular senescence and highlighting the personal attributes which made her beloved colleague and friend 
nature.com/articles/d4158…