The Human Pancreas Analysis Program - HPAP

Funding Opportunity Emerging Leader Initiative aimed at providing support and protected time for senior Postdocs seeking to pursue studies that will enhance their transition toward independent research careers. Due May 1st Learn more at: hirnetwork.org/emergingleader… Please share!

Didn’t get the grad school interview you wanted yet? Turn this year into a launchpad. The Vahedi Lab @Penn is hiring a Research Specialist A/B — ideal for undergrads & recent grads aiming for PhD/MD-PhD programs.🧬 Immunology + genomics. Apply here: tinyurl.com/2s6demtu

We are grateful that our paper science.org/doi/10.1126/sc… in @SciImmunology is featured at Penn Today; thanks to @bfariabi @TheHPAP and all collaborators tinyurl.com/24hpe9sy

A study co-led by @golnaz_v, @PennGenetics, finds new clues in pancreatic lymph nodes and the spleen that could help detect—and even stop—Type 1 diabetes. @SciImmunology spr.ly/60107Y33o

New work from HPAP! Immune cells ‘caught in the act’ could spur earlier detection and prevention of Type 1 Diabetes - pennmedicine.org/news/early-imm…

HPAP has now processed case #200! Thank you to the donors and their families. All data can be found on PANC-DB at hpap.pmacs.upenn.edu

In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: nature.com/articles/s4225…

HPAP has added 136 new bulk RNA-seq datasets to PANC-DB! Explore here: hpap.pmacs.upenn.edu

HPAP now has CODEX data available from 148 donors on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/downlo…

Please check out our @HIRN_CC webinar “Introduction to the New Islet Function Portal on PANC-DB" here: youtube.com/watch?v=UdcauF…

New research published in Nature Communications with UFDI collaborators Dr. Melanie Shapiro, Dr. Mark Atkinson, and Dr. Todd Brusko reveals immune cell disruptions in pancreatic lymphatic tissues may precede Type 1 Diabetes onset—offering key insights into early detection and intervention. Click here to read more pmc.ncbi.nlm.nih.gov/articles/PMC12… @Mel_Shapiro_PhD @matkinsonT1D @Bruskolab @UFMedicine @UFHealth @NatureComms

🚨New work from our lab with important clinical implications. Thanks to our collaborators in ⁦@TheHPAP⁩. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv biorxiv.org/content/10.110…

Two new, NIH funded postdoc positions are available! (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans - please send CV and names of references to: kaestner@upenn.edu

In the new series by Diabetes Care highlighting 75 years of NIH NIDDK research, the groundbreaking TEDDY Study is featured. This pioneering study is helping better understand the environmental determinants of Type 1 Diabetes in youth and includes UFDI faculty investigators — Dr. Desmond Schatz, Dr. Michael Haller and Dr. Eric Triplett. Click here to read more: diabetesjournals.org/care/article/d… @AmDiabetesAssn @UFPedEndo @UFHealth @HallerMichael @ewtriplett #T1D #diabetes

The new interactive HPAP perifusion data dashboard is now live on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/perifu…

HPAP recently added 49 new single-cell multiome data sets to PANC-DB! Access the data here: hpap.pmacs.upenn.edu

The January/February Issue of the HIRN newsletter is available online. Information about a recent @TheHPAP publication, @PanKbase launch, meetings/webinars and job postings! View at: conta.cc/4idBgjj

Please check out the new preprint from HPAP: Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas biorxiv.org/content/10.110…

*Job Alert* The Integrative Immunology and Cell Design Laboratory led by Dr. Mo Haj Dezfulian at the University of Pennsylvania is recruiting postdoctoral fellows! For more information: med.upenn.edu/apps/my/index.…

Looking forward to a great PANC-DB demo at the @HIRN_CC meeting!