Matthias Lutolf

@CedricBlanpain @ChenJiang919 @yura__song @Alessia100nze Huge congrats @CedricBlanpain, @ChenJiang919 and team to this beautiful paper! We are happy that we were able to make a small contribution.

Congratulations to ⁦@ChenJiang919⁩ ⁦@yura__song⁩ and ⁦@Alessia100nze⁩ the first authors for their amazing work. A big thank to our collaborators ⁦@TheLutolfLab⁩ and Alejandro Sifrim for their precious help. nature.com/articles/s4146…

Transgels enable live imaging of parasite infection in caecal models. Watch larvae invade epithelia in real-time & observe mechanisms like syncytial tunnel formation. Huge congrats to super talented @MoritzHofer_ and thanks to Maria Duque-Correa for the fantastic collaboration!

From gastric to colonic tissues: Transgel organoids replicate GI tissue architecture, including stem cell patterning and improved differentiation over time! There seem to be conserved mechanisms for geometry-induced stem cell organization and differentiation across the GI tract.

Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬 👉 nature.com/articles/s4155…

Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion.  More go.roche.com/11jc8  #TeamIHB #pRED

Please join us in shaping the future of human biology research and help to translate it into real-world applications in pharmaceutical research and development!

@milicaruoft @Roche @IHB_Research @AnnieMoisan_wl @ElisaDarcangelo Many thanks for the fascinating lecture and the introduction to the art of organ-on-a-chip engineering and its implementation into real-world applications!

So great to visit and give a talk today @Roche @IHB_Research the best place in the world for organoid implementation in pharma discovery. Great to see old friends @AnnieMoisan_wl @ElisaDarcangelo Thanks @TheLutolfLab for hosting.

@SonnenKatharina congrats!

Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: biorxiv.org/content/10.110…

Fantastic paper that exemplifies the credo and mission of @IHB_Research: bold and creative young scientists as hands-on leads + projects combining biology, engineering, computation and drug development + extremely close collaboration between multiple research groups! Congrats!!

This work has been led by the brilliant @LFranciscoLM, with invaluable support from @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, @CoukosGeorge, and Krisztian Homicsko. 🙏🙏!!

and the identification of immunomodulatory interactions among different components of the tumor microenvironment.

Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: rdcu.be/dMuAr

@kafloyd06 thanks!

Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: authors.elsevier.com/sd/article/S19… Let’s dive in!

@OttiCroze @mmanich75 Thanks! Yes, ongoing work with colleagues at IHB

@dagarfield Thanks, David! Will do 😄

@TheLutolfLab Please bring one in your luggage when you visit. :)

@AIneurolab thanks!

@AProfAram thanks!

@TheLutolfLab Amazing progress, congratulations.