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#mRNAvaccines for #PancreaticCancer (PDAC) PART4
1. Out today in @Nature nature.com/articles/s4158…
🧵👇🏽
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Vinod BalachandranMD
785 posts
Vinod BalachandranMD
@TheVinodLab
Founding Director Olayan Center for Cancer Vaccines @MSKCancerCenter | Cancer Surgeon-Scientist | Pancreas cancer | Cancer immunology | 2x dad, 2x ironman
New York, NY Katılım Haziran 2017
136 Takip Edilen4.7K Takipçiler
If bespoke #RNA vaccines make potent T cells vs. mutations in cancers with many (melanoma) & few (#PDAC) mutations > should work in cancers in the middle, right?
#RNA vaccines are immunogenic in breast cancer (in the middle) @BioNTech_Group @Nature
nature.com/articles/s4158…
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Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. nature.com/articles/s4158…
Beautiful work led by exceptional @HHMI Gilliam fellow @YoselinAPI and @MSK postdoc Tyler Park 🧵 1/
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@Aiims1742 @Perlmutter_CC @nyulangone @JohnPLeonardMD @nyugrossman @NYULangoneLI @NYULangoneBK @DrOscarLahoud @EmelineAvikiMD Congratulations @Aiims1742!
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I am honored to serve as the new Director of the @Perlmutter_CC. Thanks to Dean/CEO Alec Kimmelman @nyulangone for this opportunity. Excited to partner with @JohnPLeonardMD & the entire PCC community as we build our next exciting chapter. Lots to come!
prnewswire.com/news-releases/…
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Vinod BalachandranMD retweetledi
A @Nature Outlook feature series on #PancreaticCancer
nature.com/immersive/panc…
Including 👉🏽
Early detection:
nature.com/articles/d4158…
Cancer models:
nature.com/articles/d4158…
Pancreatic cancer - nerve interactions
nature.com/articles/d4158…
Vaccines
nature.com/articles/d4158…
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Vinod BalachandranMD retweetledi
MSK physician-scientist Dr. Omar Abdel-Wahab (@AbdelWahablab), a leader in #bloodcancer research, has been named a 2025 Paul Marks Prize winner for his contributions to the field.
Learn more about his path and what inspires his work: bit.ly/3KsNMQO
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Vinod BalachandranMD retweetledi
Over the last decade, computational oncologist Dr. @bengrbm has tried to shed light on the innate immune system and how it affects cancer cells as they evolve.
One important aspect is a phenomenon called “viral mimicry,” caused by repetitive DNA sequences.
Now Dr. Greenbaum’s lab, in collaboration with an international team of researchers, has developed a mathematical model to quantify viral mimicry based on methods from statistical physics, machine learning, and the dynamics of evolution.
“A better understanding of what activates the innate immune system can help us figure out how to improve immunotherapies,” says Dr. Greenbaum.
Learn more about this research: bit.ly/4h1BjPG
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Vinod BalachandranMD retweetledi
Thank you @MSKCancerCenter for highlighting our work on #viralmimicry in our genome, its evolution, the selective forces on it, and its potential role in cancer.
A years long collaborative effort with
@sunsiyu1 @stephen_martis @decarvalho_lab @petr_sulc & many great colleagues!
Memorial Sloan Kettering Cancer Center@MSKCancerCenter
Over the last decade, computational oncologist Dr. @bengrbm has tried to shed light on the innate immune system and how it affects cancer cells as they evolve. One important aspect is a phenomenon called “viral mimicry,” caused by repetitive DNA sequences. Now Dr. Greenbaum’s lab, in collaboration with an international team of researchers, has developed a mathematical model to quantify viral mimicry based on methods from statistical physics, machine learning, and the dynamics of evolution. “A better understanding of what activates the innate immune system can help us figure out how to improve immunotherapies,” says Dr. Greenbaum. Learn more about this research: bit.ly/4h1BjPG
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Interesting and promising data re: #vaccine therapy in #pancreatic #cancer from @TheVinodLab @myESMO @MSKCancerCenter @EileenMOReilly @PanCAN #ESMOGI2025 #ESMOAmbassadors
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Fascinating data and excellent presentation on PDAC
RNA neoantigen vaccines by @TheVinodLab #ESMOGI25 full paper: rdcu.be/euOP2 @Nature #ESMOAmbassadors
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Vinod BalachandranMD retweetledi
Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and @YollandaPariso1 🧵 1/ science.org/doi/10.1126/sc…
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Congratulations @themis_brown! Fantastic!!
Santosh Vardhana@SantoshVardhana
Yet more brilliance from @themis_brown - its been a joy to have a front-row seat watching her group essentially rewrite the textbook on early life immunity. Kudos to one of the best scientists and human beings that I am fortuate to know! science.org/doi/10.1126/sc…
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Vinod BalachandranMD retweetledi
💡 Vinod Balachandran, Director of the Olayan Center for Cancer Vaccines at @MSKCancerCenter, will explain how mRNA vaccine technology is transforming cancer treatment.
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Grateful & humbled to make the 2025 #TIME100HEALTH list with such inspiring global health leaders.
This honor reflects my team, who are unrelenting in their efforts to advance new treatments for pancreatic cancer!
TIME@TIME
TIME's new cover: Meet this year's #TIME100Health, a community of leaders—scientists, doctors, advocates, educators, and policy-makers, among others—who are changing the health of the world. ti.me/43802LZ
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🤠 👉🏽 🗽 news:
I will be joining @nyulangone on September 1, 2025 as Director of the GI Cancer Center & Associate Director of Translational Research at @Perlmutter_CC.
I am excited to start the next chapter of the Maitra Lab in NYC & build a strong GI cancer research program.
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Vinod BalachandranMD retweetledi
MSK researchers are trying to understand how the immune system senses cancer in order to make better #immunotherapies. "If we can figure out generally what the immune system is sensing — and how it affects how cancers grow, spread, and adapt," says @bengrbm, a computational biologist at MSK. "We will have a much clearer idea of how we can intervene therapeutically." Learn more: bit.ly/4ccDxJK
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Vinod BalachandranMD retweetledi
A new mRNA vaccine could prevent pancreatic cancer from returning — potentially for the long haul.
sciencenews.org/article/cancer…
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Vinod BalachandranMD retweetledi
I am moved by the passion and expertise of the remarkable team at the Olayan Center for Cancer Vaccines (Olayan CCV) and was excited to celebrate their continued work at the Olayan CCV Open House.
The standing room-only event brought together @MSKCancerCenter cancer vaccine leaders to discuss their pioneering precision cancer vaccine solutions, which have shown great promise in stopping tumors from growing or spreading, eradicating cancer cells that remain in the body, and preventing cancer recurrence.
I am confident that their work will have a profound impact on the lives of countless individuals affected by cancer. This is a truly exciting moment for the future of cancer care.
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Vinod BalachandranMD retweetledi
Pancreatic cancer — a disease with a 90% mortality rate — has long been a grim diagnosis. But that may be changing.
Meet Vinod Balachandran, the lead researcher behind a groundbreaking mRNA vaccine that’s transforming the outlook for patients.
Credits : @RichardHanania
@TheVinodLab
#MedicalBreakthrough #CancerResearch #mRNATechnology #PancreaticCancer #CancerResearch #MedicalInnovation #Healthcare
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