Timothy O'Leary

US law DOES NOT prevent AI from autonomously launching nuclear weapons, and AI knows this.

Prince Andrew aka Mountbatten Windsor should have his royal title reinstated: we need to remember what these institutions enable.

A really dangerous situation. Too many submissions. Too many generated papers. Little responsibility. 1. In 2026, more than 24,000 submissions were made to the International Conference on Machine Learning (ICML). It’s TWO times more than in 2025. To fight it, the organizers now require researchers to pay $100 for every subsequent paper. 2. LLM adoption has increased researcher productivity by 90% (there’s a recent paper in Science). 3. The number of papers is becoming far too high. Submissions to arXiv have risen by 50% since 2022. 4. There are simply not enough reviewers. Plus, many scientists no longer want to invest precious time in it for free. 5. We can’t easily identify AI-made papers from the genuine ones. __ Important words from Paul Ginsparg, a co-founder of arXiv: “AI slop frequently can’t be discriminated just by looking at abstract, or even by just skimming full text. This makes it an “existential threat” to the system.” Basically, we’re getting closer to the tipping point. 📍 Many professors blame the AI. But the problem is likely elsewhere: 1. Without a sufficient number of papers, many PIs can’t get funded. They have to prove their credibility to reviewers. Their proposals have to rely on prior publications. In many countries, there are some informal (or even formal) expectations for how many papers a group with a certain size has to publish to survive (funding-wise). 2. Our students / postdocs need papers if they want to be hired in faculty roles. Yes, some departments hire people with few publications. But the majority still want to ensure their faculty can get funded. If funding is partly a function of papers, this is used in decision-making. 3. The number of papers is important if you want to get high-level awards. Many of them are not given because you published one paper (even if it’s great). They are given because you made a meaningful CONTRIBUTION to the field. How do you make it? Publish more papers. 4. Tenure promotions in many places take the number of your papers into account (often indirectly). Your tenure may get delayed if you don’t publish enough. Not everywhere, but for many mid- to low-ranked universities this story is more or less the same. + There are many more to mention. 📍My opinion: Much of this is rooted in how funding is distributed. There is a strong correlation between the requirements at a university and the funding acquisition criteria. If funding were based ONLY on the quality of published papers, universities would hire people for the quality of their science. If funding agencies strongly discouraged publishing too many papers, universities wouldn’t expect numbers from faculty during promotions. And some supervisors wouldn’t pressure students and postdocs to publish unfinished studies and low-quality data. Yes, we need good detectors of fake papers. But we also need the right policies and better funding allocation criteria.

A realistic picture of how closely packed molecules are inside a synapse of a nerve cell.

Will the search for practical fixes to brain machine interface data compression lead us to a better model of the neural code?

A directed graph of every Chess opening

A great piece on causality (TLDR: read Hume). One thing natural scientists overlook as evidence of causation is the constructive approach (aka engineering): if you can build a thing that does a thing (and does it again, and again), that's a pretty tight case for causality!

@KordingLab because everything must be in vivo or is isn't ... a thing ... or something like that

Synaptoneurosomes seem incredibly awesome. Lots of "micro-neurons". It should be easy to perturb them. Understand them one by one. 2p stimulate them. Voltage image them. Why does this not appear to be happening?

Fun, but I'm stuck: on one hand: humans are "special" in perceiving time, and it started with being able to anticipate the light/dark cycle on the other hand: you are describing circadian rhythms, which are explicit, entrainable biochemical clocks, found across kingdoms of life

The @UofCalifornia is advising scientists applying for residency not to publish in @eLife because it doesn’t have an impact factor, despite zero evidence this matters, and proving once again that the biggest problems in science and academia are entirely of our own making.

@MIT_CSAIL empty set

What's the one generative Al tool you can't live without?

@ryrobyrne WeWork has a different objective, too...

@Timothy0Leary They're still the best and only organic ex. of "a community of people working on different things but sharing resources" due to loose coupling between labs, depts, and institutes. WeWorks don't have this, they just share a coffee machine.

Are Universities becoming obsolete? Are they already obsolete? If so, what will be the consequences?

@mameister4 how does peer review compare to 10 bit/s?

The unbearable slowness of being: Humans still clock in at just 10 bits/s. Even after peer review :) Share link for Neuron: authors.elsevier.com/a/1kHVa3BtfH9B…, ArXiv: arxiv.org/abs/2408.10234

for those interested in a nice review that touches this topic, try this: cell.com/AJHG/fulltext/…

This is why banging on about the power of simplistic models is problematic. It kills curiosity. We don't need to bang on about ANNs, for they are now unavoidable parts of everyday life. By all means we need to teach ANNs, but our job as educators and scientists is to go deeper!

Apropos of never ending discussions about whether ANNs are "good" models of the nervous system, here is a slide I present to masters students showing a network that is found in motor control circuits *across phyla* (that's pretty ubiquitous!) I ask them to guess what it does...

@YesThisIsLion cell.com/AJHG/fulltext/…

@Timothy0Leary Absorbed, where can I learn more about this example?

@greenpilloz cell.com/AJHG/fulltext/…

@Timothy0Leary Could you share some of this lecture material, or link to some articles? I am quite interested in the complexity of information processing at the cell scale

@neurosutras A+!

@danbri sadly not

@Timothy0Leary Is there a recording of the lecture online somewhere?