
Anthony
5 posts





TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in @ChemRxiv (chemrxiv.org/engage/chemrxi…). Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J is disclosed. Commencing from inexpensive starting materials, this marine diterpenoid was fashioned through a highly convergent synthesis enabled by two Ni-electrocatalytic decarboxylative cross–couplings (DCC) leveraging succinate as an ethylene 2-carbon bridge, a unique halogen dance- Zweifel sequence to rapidly access a trisubstituted furan, a recently disclosed Ni-catalyzed 1,6-conjugate addition, and an asymmetric proton transfer. Shout out to the team that made it happen: @tonyjohn07 @griffin__barnes @maithiliterpene


TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in @ChemRxiv (chemrxiv.org/engage/chemrxi…). Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J is disclosed. Commencing from inexpensive starting materials, this marine diterpenoid was fashioned through a highly convergent synthesis enabled by two Ni-electrocatalytic decarboxylative cross–couplings (DCC) leveraging succinate as an ethylene 2-carbon bridge, a unique halogen dance- Zweifel sequence to rapidly access a trisubstituted furan, a recently disclosed Ni-catalyzed 1,6-conjugate addition, and an asymmetric proton transfer. Shout out to the team that made it happen: @tonyjohn07 @griffin__barnes @maithiliterpene

