Trini Ochoa

A major work from our lab is out in Science! @ScienceMag, another key step towards a true demonstration of RNA self-replication. science.org/doi/10.1126/sc… (1/6)

@miner_lab Very thankful to join the team!

Welcome to our newest lab member—postdoctoral fellow Trini Ochoa. @TrnOchoa With the help of amazing collaborators @PennMedicine and @umichmedicine Trini will test endothelium-targeted lipid nanoparticle gene therapies & first-in-class small molecules against TREX1, designed for patients with RVCL. Thank you to Clayco Foundation for their recent visit to @Penn and continuing support of our efforts.

Ancient #retroviruses may be to thank for the evolution of vertebrate #myelin tissue—and, by extension, our large, complex brains. Read more in @CellCellPress: cell.com/cell/fulltext/… @altos_labs Tanay Ghosh, Robin J.M. Franklin

Highly recommend this book to anyone interested in the biology of diseases. A systematic explanation of what, how, and why, can go wrong resulting in a particular spectrum of human disorders. The book is a foundation for a new branch of biomedical science.

💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s4158…

There's the paper title, then there's the article about the paper title: sciencealert.com/the-immune-sys…

“For the 20 years that we worked together before anybody knew about us or cared it was literally the two of us sitting side by side at a bench and working together. Usually at 3 or 5am we would be emailing each other with new ideas.” - 2023 medicine laureate Drew Weissman on his partnership with his co-laureate Katalin Karikó. Keep an eye out for our telephone interview with Weissman, coming soon!

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

@MontseArreguin @kelliejurado @pennbgs @IGGPenn Congratulations Montse! 🎉

I am so honored and grateful to have been awarded the Gilliam Fellowship! Thank you to my amazing mentor, @kelliejurado, for your endless encouragement and guidance! I look forward to being part of this incredible community! 🥳🥳🥳 @pennbgs @IGGPenn

A paper in @Nature reports the discovery of a new type of steroid in ancient rocks. The findings fulfils the prediction of Nobel Prize winner Konrad Bloch, who posited the existence of primordial steroid molecules. go.nature.com/42GeV5D

Day 11 of great papers in biology. "Genetic regulatory mechanisms in the synthesis of proteins," by Jacob & Monod (1961). This study on the lac operon deciphered how genes are regulated in bacteria. It's a surprisingly circuit-oriented paper that established the lexicon for future work in synthetic biology. *** Just 8 years after Watson & Crick's DNA structure appeared in Nature, two French biologists at the Institut Pasteur, named François Jacob and Jacques Monod, demonstrated "that the genome contains not only a series of blue-prints, but a co-ordinated program of protein synthesis and the means to control its execution." This was the foundation of DNA as a genetic program, rather than an inert string of letters. Prior to this work, many geneticists surmised that, perhaps, DNA was directly converted into proteins. This paper "described an operon," a cluster of genes in bacteria, that act "as a simple control circuit where a collection of structural genes could be regulated in a coordinated fashion," writes Mitchell Lewis. (ncbi.nlm.nih.gov/pmc/articles/P…) "Regulating the ensemble of proteins requires a master switch, called the repressor molecule, which is produced from a regulator gene...when the regulator binds to a specific site on the genome, an operator, it blocks transcription of the structural genes." Jacob and Monod shared a Nobel Prize in 1965 for this work. All of their findings have held up remarkably well over the last 60 years, even though the paper includes many speculations (including the existence of a "messenger RNA," which was also experimentally confirmed in 1961.) Photo below: The lab where Monod worked at the Institut Pasteur. Paper: doi.org/10.1016/S0022-… Full text: gs.washington.edu/academics/cour…

@deniswirtz @Stanford @RockefellerUniv @Yale @Penn @Cornell @Harvard @JohnsHopkins @UChicago @Princeton @UCLA Thank you so much for this incredible resource!

Download our free database of POSTDOC fellowships. 373 different types of postdoc fellowships. For each entry, we provide description, deadline, $ amount, and eligibility. Download here: research.jhu.edu/rdt/funding-op…

Interested in finding fungi, protists or worms in your #metagenomic data 🔍🦠🪱? Look no further. Check out our new article now out in @microbiomej! Round up those microbial eukaryote sequences in your data using our new software, CORRAL 🤠. 🧵 (1/4) doi.org/10.1186/s40168…

@Hildy46 @AmyPRossi Huge congrats! @AmyPRossi

Congrats to my PhD student. Dr @AmyPRossi ! Who did a fantastic job defending her PhD dissertation "Perturbing Proteostasis to Deplete Plasma Cells". Great job Amy !

The majority of Australian shallow-reef species experienced population declines between 2008 and 2021, according to a study in @Nature. The trend suggests that greater conservation efforts are needed to safeguard marine ecosystems from climate change. go.nature.com/3z1AOjH

An interesting read ☀️

An early Cretaceous bird ancestor, Confuciusornithids, sheds light on flight evolution. In the Nature Portfolio Ecology and Evolution Community, Dongyu Hu describes a new species that shows characteristics suitable for aerial manoeuvrability. go.nature.com/3YBrXjg

A new era of biological engineering is emerging in which living cells are used as building blocks to address therapeutic challenges. Read more in a recent #ScienceReview: scim.ag/15I

@RMedzhitov I wonder what Charles Janeway would’ve thought about bacteria having PRRs! science.org/doi/10.1126/sc…

CRISPRing a path to better T cell therapeutics dlvr.it/SdsxdB