Tsung-Yu Lu (Tony)

34 posts

Tsung-Yu Lu (Tony)

Tsung-Yu Lu (Tony)

@TsungYuLu1

CompBio postdoc at the Chaisson lab. 🏳️‍🌈🇹🇼

Los Angeles, CA Katılım Temmuz 2020
130 Takip Edilen59 Takipçiler
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Tsung-Yu Lu (Tony)
Tsung-Yu Lu (Tony)@TsungYuLu1·
Excited to update our manuscript with many major improvements in genotying VNTR motifs and profiling their impact on gene expression. Special thanks to @PaulinaNSmaruj and @gfudenberg for adding the cool genome folding analysis, and @nmancuso_ for guiding association studies.
Mark Chaisson@mjpchaisson

After a lot of work, happy to post the revised version of our manuscript relating tandem repeat motif variation to expression by @TsungYuLu1 From some great reviewer comments (review not broken), we've updated: biorxiv.org/content/10.110…

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Tsung-Yu Lu (Tony)
Tsung-Yu Lu (Tony)@TsungYuLu1·
Even in the case where motif count correlates with VNTR size, sequence compositions provide insights into potential regulation mechanism, as illustrated in the HRNR case. The perturbation on genome folding can be well predicted by the number of CTCF binding sites in the repeat.
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Tsung-Yu Lu (Tony)
Tsung-Yu Lu (Tony)@TsungYuLu1·
The holy grail of this paper is to show that motif composition explains trait variations in certain scenarios that could not be explained by VNTR length. We highlighted the promoter VNTR of RNF213 that is predicted to have TF binding sites in certain expanded alleles but not all.
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Tsung-Yu Lu (Tony)
Tsung-Yu Lu (Tony)@TsungYuLu1·
Excited to update our manuscript with many major improvements in genotying VNTR motifs and profiling their impact on gene expression. Special thanks to @PaulinaNSmaruj and @gfudenberg for adding the cool genome folding analysis, and @nmancuso_ for guiding association studies.
Mark Chaisson@mjpchaisson

After a lot of work, happy to post the revised version of our manuscript relating tandem repeat motif variation to expression by @TsungYuLu1 From some great reviewer comments (review not broken), we've updated: biorxiv.org/content/10.110…

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Tsung-Yu Lu (Tony)
Tsung-Yu Lu (Tony)@TsungYuLu1·
“Rises in brain temperature reliably trigger yawning, and yawning is followed by decreases in brain temperature” I yawn because my brain is having a heated debate!? science.org/content/articl…
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Mark Chaisson
Mark Chaisson@mjpchaisson·
Happy that Quentin's paper is out in Genome Biology! Some exciting updates to come, including aggregate analysis of fragmented SV calls.
Genome Biology@GenomeBiology

Yang & @mjpchaisson present TT-mars, for structural variant assessment based on haplotype-resolved assemblies. Rather than comparing sets of variant calls, TT-mars validates variants by comparing the implied sequence to haplotype-resolved assemblies genomebiology.biomedcentral.com/articles/10.11…

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Doc Edge
Doc Edge@DocEdge85·
I'm looking to hire a postdoc to work on questions related to genetic privacy, forensic genetics, and complex traits from a population-genetic perspective. Please RT and write to me if interested. jobrxiv.org/job/university…
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Mark Chaisson
Mark Chaisson@mjpchaisson·
Preprint online showing a "flipped" approach to variant validation: compare how a call set estimates a genome rather than how calls overlap, work done by Quentin Yang TT-Mars: Structural Variants Assessment Based on Haplotype-resolved Assemblies biorxiv.org/content/10.110…
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Anicca Harriot, PhD🔬
Anicca Harriot, PhD🔬@13adh13·
Academic writing is wild bc you’ll read four articles just to write one sentence. Anyway, here’s a thread of resources I’ve been using to speed through this review I’m working on:
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Eric Vallabh Minikel
Eric Vallabh Minikel@cureffi·
Short answer, it's early and we don't know anything, but since everyone is asking, here's my take on what the halting of the tominersen Phase III Huntington's disease trial means for our efforts in prion disease: cureffi.org/2021/03/24/hun…
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Yoav Gilad
Yoav Gilad@Y_Gilad·
I am looking for couple of new postdocs. Please see details in enclosed text. Please RT and share broadly. Thank you.
Yoav Gilad tweet media
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Yun S. Song
Yun S. Song@yun_s_song·
Here are my lecture notes on Computational and Mathematical Population Genetics that I have been sporadically working on for several years. I don't know whether I will ever be able to finish, so decided to release them now. Please share with your friends: github.com/popgenmethods/…
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Hsiao Yi
Hsiao Yi@hsiaoyi0504·
Dr. Peter Jin is looking for a postdoc interested in multi-omics analysis, computational method development, structural variation, and/or functional genomics using zebrafish, to join his lab at Washington University School of Medicine. See scjin.github.io for more info.
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Keşfet

@PaulinaNSmaruj @gfudenberg @nmancuso_ @UniklinikDUS @MedHHU @HHU_de @MathiThiru95 @clairearataphd