Ty Miller Lab

Proud to share our latest work in @nature, co-led by @chadi_elfarran, @CouturierMDPhD & @BradEBernstein! We developed a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies🧵 nature.com/articles/s4158…

@DanSimonMD, sits down with Matthew Anderson, MD, PhD @TyMillerLab for a deep dive into the brain, from autism to glioblastoma and immune-based therapies. Hear how @Uhhospitals scientists are pushing the boundaries of neuropathology: tinyurl.com/3e2wkfmk

@ZhaohuiWang5 Thanks Zhaohui!!

Day 1 at #AACR2026—an energizing start. A standout talk by Tyler Miller explored myeloid cell classification and the emerging strategies to reprogram these populations in glioma. Clear momentum toward reshaping the tumor microenvironment for therapeutic impact @TyMillerLab

@CalebLareau @CalebLareau this is awesome! I assume you have tried on flex V2? Works basically the same?

Interested in unwrapping your own GIFT? GIFT comes fully loaded with a benchside protocol, software for designing GIFT probes, a package (aptly named giftwrap) for parsing all data, and a reproducible code repository (see preprint for details). Try it out today! 16/n

We’re unwrapping a new method today @MSKCancerCenter! Led by @SydneyBlattman, @NabihMaslah, @AustinAVarela, Ronan Chaligne and @dana_peer, plus colleagues at @10xGenomics, we’re delighted to share Genotyping In Fixed Transcriptomes (GIFT): biorxiv.org/content/10.648… 1/n

Was a fantastic 2 days in Philly for the American Association for Cancer Research's Special Conference on Brain Cancer! Global leaders in brain cancer research gathered to share their latest research. Was honored to present ours and chair the session on Neuro Immuno-Oncology. Always great to catch up with friends and establish new collaborations that push forward research faster (and have some fun doing it!)

Advances in NeuroImmunoOncology: Tyler E. Miller, David Gutmann, and Lukas Bunse addressed this topic in a plenary session at the AACR Special Conference on Brain Cancer. #AACRbrain26 @TyMillerLab @GutmannLab @L_Bunse

@snaga13 @JD_Buenrostro @Nature Congrats man, happy for you!!

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

Big congrats to our resident (and future physician–scientist!) @QingLi_MDPhD on earning a $1,000 travel grant to attend the 2026 @RadiologyACR Annual Meeting, supported by #CARROS & ACR 👏🏼🥳 So glad to see your hard work recognized! ✈️📚 #RadOnc #holmanpathway @TyMillerLab

@TheMarkFdn @the_asci @MarioSuva @Samuel_Bakhoum I'm not sure these guys are "Emerging" leaders... Congrats @MarioSuva! (You've been leading our field for a decade 😆)

🌟Our Emerging Leader Award winners are superstars - and two of them were just elected to @the_asci! Congratulations, @MarioSuva and @Samuel_Bakhoum! 🚀 the-asci.org/controllers/as…

@JennGuerriero @LuRongze Love this 🥰

Our daughters are watching. They are learning what leadership looks like. They are deciding whether their hard work will be celebrated — or sidelined. I’m sharing this photo of my daughter with me at a conference from last week in Colorado, where she watched me present the science from my lab on a big stage. My lab @BrighamWomens @MGBResearchNews is making huge advances towards new cures for cancer. I want her to see women leading, competing, discovering, winning — and being recognized for it. Gold medals matter. Breakthroughs matter. Effort matters. And the next generation deserves to see those achievements honored — without qualification.

@sitcancer @sontagfdn @theABTA @BrainTumourOrg Thank you!

@TyMillerLab @sontagfdn @theABTA @BrainTumourOrg Sure thing Dr. Miller - just reposted!

🧬 We’re hiring: Computational Biologist – Cancer Immunology & Rare Cancers We’re building the computational engine behind next-generation immunotherapies. Our lab at Case Western Reserve University is seeking a computational biologist to work at the intersection of: • Single-cell genomics • Spatial transcriptomics • Tumor immunology • Brain tumors & rare cancers This is a central, high-impact role — working directly with patient-derived datasets to define immune programs that inform therapy. Ideal background: strong bioinformatics training, R/Python fluency, single-cell experience (spatial/multimodal a plus). Two scientists currently in this role are now headed to MSTP/PhD training at CWRU this summer. Apply: lnkd.in/gNpXUVtT Lab: tymillerlab.org #computationalbiology #singlecell #spatialbiology #rarecancer

We are pleased to recognize Dr. Tyler Miller as a 2025 Distinguished Scientist Award Recipient. "We believe this project will result in meaningful contributions to the field of brain cancer research.” -Hilary Keeley. Read more: bit.ly/3OeMFFS @TyMillerLab

Advances in NeuroImmunoOncology: Tyler E. Miller, David Gutmann, and Lukas Bunse will address this topic in a plenary session at the AACR Conference on Brain Cancer (March 23-25, 2026; Philadelphia). brnw.ch/21wZVWD #AACRbrain26 @TyMillerLab @GutmannLab @L_Bunse

Tyler Miller, MD, PhD @TyMillerLab, received the Sontag Foundation Distinguished Scientist Award to advance glioblastoma research. This support will help uncover and target immunosuppressive pathways, aiming to combine new treatments. Read more: bit.ly/4rmd0R2

How the lab thinks of itself

Happy birthday Regan and @Shawn_T_Ho! Miller lab tradition continues!

We are pleased to announce that UH Cleveland Medical Center is one of the most recognizable hospitals among doctors in the U.S. and around the world, according to an annual survey conducted by @BrandFinance. You can read the full report here: brandirectory.com/reports/hospit…

@TaylorJ_MD @sontagfdn Thank you!

@TyMillerLab @sontagfdn Congratulations!

Honored to receive the Distinguished Scientist Award from @sontagfdn! Excited to join this family of leading #GBM researchers and use the funding to accelerate our research towards finding new therapies for this devastating disease. case.edu/news/case-west…