UCLA Vascular Biology Lab

BMP binding by matrix Gla protein (MGP) is essential for limiting aortic fibrosis but not the anti-calcific effects. @UCLAVascularBio @XinjiangCai @Wu_Xiuju @Zhanglily19 @juliyan_g ahajrnls.org/4bubqXm

Fresh from the press - please check out our article published online by ⁦@MolMetab⁩ today. ⁦@zhanglily19⁩ ⁦@XinjiangCai⁩ ⁦@dgsomucla⁩ Regulating the Cell Differentiation Trajectory of Progenitor Cells in Adipose Tissue Fibrosis sciencedirect.com/science/articl…

Check out our paper on AVM and hemorrhagic telangiectasia type 2 published in Circulation today! Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations ahajournals.org/doi/10.1161/CI…

Hot off the press from our lab! ⁦@CircAHA⁩ ⁦@DOM_UCLA⁩ Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations | Circulation ahajournals.org/doi/10.1161/CI…

JCI in press - our most recent paper on EndMT and cerebral AVMs. It will be a fantastic read! @UCLAHealth @DOM_UCLA @dgsomucla @uclaCVfellows JCI - Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions… jci.org/articles/view/…

Check out our most recent publication on fibrosis in patients with Fontan Procedure published in @JACCJournals. In collaboration with our adult congenital heart disease and transplant surgeon teams @dgsomucla @DOM_UCLA @UCLAHealth sciencedirect.com/science/articl…

Check out our new publication in JCI Insight - CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification @vascularbiology @JCI_insight @DOM_UCLA @dgsomucla insight.jci.org/articles/view/…

Please join us at the next NAVBO InFocus session on Thursday 01/25/24. Dr. Li Zhang @zhanglily19 from our lab will present her recent report on the role of matrix Gla protein in adipogenesis.@DOM_UCLA @dgsomucla

Our paper exploring brown adipose tissue differentiation regulated by Matrix Gla Protein has just been published by ⁦@MolMetab⁩. Congratulations to ⁦@zhanglily19⁩ from our lab at ⁦@DOM_UCLA⁩ ⁦@dgsomucla⁩. sciencedirect.com/science/articl…

Dr. Li Zhang @zhanglily19 from @UCLAVascularBio @dgsomucla presented her research on the role of matrix Gla protein in brown adipose tissue development at the Vascular Biology 2023 meeting. Five lab members attended the @vascularbiology meeting. It was a fantastic experience!

Aurora Kinase A Regulates Cell Transitions in Glucocorticoid-Induced Bone Loss. Take a look! mdpi.com/2073-4409/12/2…

We used publicly available databases to study the relationship among COVID-19, endothelial cells, and Pulmonary Fibrosis mdpi.com/1422-0067/24/1…

Just published in the Special Issue GSK3 as a Master Regulator of Cellular Processes - GSK3β Inhibition Ameliorates Atherosclerotic Calcification. @MDPIOpenAccess @IJMS_MDPI mdpi.com/1422-0067/24/1…

Hot off the press! “… the results suggest that glucocorticoids suppress osteogenic capacity and cause bone loss at least in part through previously unrecognized osteoblast–endothelial transitions.” @endothelialnews mdpi.com/2073-4409/12/1…

A new perspective on pulmonary fibrosis - take a look at our recent paper published online in the European Respiratory Journal @ERSpublications Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis erj.ersjournals.com/content/early/…

Happy Holidays! We would like to introduce to you our newest lab members! @uclachem @dgsomucla @UCLACollege Jocelyn Ma is a brilliant UCLA undergraduate majoring Biochemistry. She and Jaden are both working on the Matrix Gla Protein. Here is her introduction and a fun photo.

Happy Holidays! We would like to introduce to you our newest lab members! @MicrobioUcla @dgsomucla @UCLACollege This is Jaden Ji - a talent third year UCLA undergraduate majoring Microbiology, Immunology, and Molecular Genetics. Here is her introduction and a fun photo.

Come to visit us at the poster session at noon today! @vascularbiology @ivbm2022. Poster #3122 #3137 #3138. Topics range from cardiac transition from adipose derived cells, congenital heart disease, to vascular calcification! @DOM_UCLA @dgsomucla @UCLAVascularBio

The 14th HHT International Scientific Conference @curehht #HHT2022 provided memorable days and science in Estoril, Cascais, Portugal, and we were honored to present our work on matrix gla protein and arteriovenous malformations. @UCLAHealth @DOM_UCLA @dgsomucla