Ultra Skool 🧠

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Ultra Skool 🧠

Ultra Skool 🧠

@UltraSkool1

Diving deep into the mysteries of Microtubules, Consciousness, and Quantum Biology!

The Platonic Realm Katılım Haziran 2024
16 Takip Edilen4.5K Takipçiler
Ultra Skool 🧠
Ultra Skool 🧠@UltraSkool1·
Vagal Nerve Myelination has decreased 30% since the 1940s. The Vagus Nerve governs heart-brain communication, modulating heart rate, heart rate variability, and helps prevent anxiety burnouts ! It's the gut-emotion expressway, inflammation fighter, and heart-brain bridge all in one. Modern life is tough on it. Is your heart rate zoomin' above 80 at rest? Try this quick biohack: exhale a little longer than you inhale. Think of it as a gentle nudge to get things moving again. Your vagus nerve will thank you! skool.com/vagus/classroo…
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Ultra Skool 🧠
Ultra Skool 🧠@UltraSkool1·
The paradigm of neuromodulation is shifting. Vagus Nerve Stimulation (VNS) traditionally required invasive surgical implants to deliver electrical impulses. These devices carry inherent risks of infection and hardware failure. Low-Intensity Focused Ultrasound (LIFU) replaces the scalpel with precision acoustics. By utilizing transcutaneous waves, clinicians can now modulate vagal neurons without a single incision. This method leverages mechanical energy to alter neural excitability at depth. LIFU precisely regulates autonomic balance, suppresses pro-inflammatory cytokines, and adjusts heart rate variability. It is a targeted approach to systemic health via the nervous system. Recent trials demonstrate efficacy in treating tinnitus and stroke recovery. This transition to non-invasive wave mechanics democratizes chronic care through safer, scalable interventions. skool.com/vagus/precisio…
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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
OK. Consider cortical pyramidal neurons, apex of the perception-action cycle, their axons can fire directly to spinal cord fur behavioral control. According to convention, these axons fire when the integrated dendritic-somatic membrane potential reaches a critical threshold to ‘fire’ the all-or-none action potential, firing or spikes. Hodgkin Huxley, McCulloch-Pitts integrate and fire, the bases for the brain computer analogy when firings are are then taken as bit-like information states. But in awake cats the threshold varies spike to spike. Some noncomputable factor influences firing, perfect place for consciousness and dendritic somatic microtubules the obvious source. That’s how Orch OR manages brain wide consciousness pubmed.ncbi.nlm.nih.gov/35782391/
Consciousness Mechanics@Conmechorg

@Millbstrd @StuartHameroff Can I ask a more concrete question, how does quantum behaviour in microtubules implement threshold gating in a noisy biological system? i.e. how does it determine when a signal crosses a threshold and triggers a change in behaviour vs being suppressed?

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Ultra Skool 🧠
Ultra Skool 🧠@UltraSkool1·
@MTomasson Could be if you shape water like a Microtubule then you get consciousness - sounds perfectly reasonable
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Sterling Cooley
Sterling Cooley@SterlingCooley·
Rheumatoid Arthritis (RA) is often viewed through the lens of joint damage, but its roots lie deep within the autonomic nervous system. skool.com/vagus/rheumato… Chronic inflammation in RA stems from a persistent imbalance: an overactive sympathetic drive paired with a weakened vagal tone. The vagus nerve serves as the primary conduit of the parasympathetic system, regulating Heart Rate Variability (HRV) and systemic inflammation. Low HRV is a clinical marker for RA severity, correlating with heightened pain, fatigue, and the overproduction of pro-inflammatory cytokines. Vagus Nerve Stimulation (VNS) offers a targeted intervention by activating the cholinergic anti-inflammatory pathway. This mechanism signals the immune system to dial down TNF-alpha—the specific protein responsible for driving synovial inflammation and bone erosion. Clinical trials indicate that VNS significantly reduces disease activity scores (DAS28-CRP) without the side effects of heavy immunosuppressants. By restoring autonomic balance, we move beyond mere symptom masking toward a fundamental recalibration of the body’s internal resilience.
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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
All God’s children have microtubules, including single cell organisms for which they sense, move, learn and encode memory. Associative learning also needs reward, something that feels or tastes good, something involving consciousness. We can’t understand consciousness with complex brain networks so how do we know qualia aren’t Funda-mental everywhere at tiny fast scales, accessible through quantum brain biology. Roger Penrose suggested that in 1989. pubmed.ncbi.nlm.nih.gov/35782391/
Sheila Macrine, Ph.D.@MacrinePhD

No brain? No problem! A simple single-celled organism without a brain or neurons appears to be capable of an advanced form of learning. Scientists have discovered that Stentor coeruleus, a giant single-celled organism, is capable of advanced associative learning. It can connect different stimuli without a single neuron—just like Pavlov's dogs! repo.enc.edu/2026/03/13/a-s… #DiverseIntelligence #Microbiology #ScienceNews #biology #StentorCoeruleus #CellularCognition #STEM #ScienceTwitter #Research #SamuelGershman@ gershbrain.bsky.social

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Ultra Skool 🧠
Ultra Skool 🧠@UltraSkool1·
We’ve been lied to about medicine. We think health is a chemical balance, a cocktail of pills and biologics. But what if the "pharmacy" is actually a circuit board? Recent data shows Vagus Nerve Stimulation (VNS) is matching the power of heavy-duty drugs for RA and Lupus—without the toxic side effects. By pulsing the ear or neck at 20Hz, we aren’t just "treating" symptoms. We are hijacking the cholinergic anti-inflammatory pathway. We are literally "zipping up" cytokine storms by signaling splenic macrophages to stand down. If an ear clip can reduce TNF-α by 45% and CRP by 65%, why are we still addicted to systemic immunosuppressants? The future isn't a new molecule. It’s a new frequency. Is your body a chemistry set or a computer? If we can hack the neural brakes on inflammation, the entire pharmaceutical model is obsolete. We aren't just patients; we are programmable systems. It's time to stop medicating and start modulating. sciencedirect.com/science/articl…
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Ultra Skool 🧠@UltraSkool1·
The universe beholds itself. Subjectively. Each of us is a microcosm. The cosmos is not some distant entity. It lives through our senses and thoughts. This subjective experience is profound. It binds us to the universal fabric. Each life, a unique perspective. A continuous act of cosmic introspection. Consider this when you look at the stars.
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Sterling Cooley
Sterling Cooley@SterlingCooley·
Rheumatoid Arthritis (RA) is often viewed through the lens of joint damage, but its roots lie deep within the autonomic nervous system. skool.com/vagus/rheumato… Chronic inflammation in RA stems from a persistent imbalance: an overactive sympathetic drive paired with a weakened vagal tone. The vagus nerve serves as the primary conduit of the parasympathetic system, regulating Heart Rate Variability (HRV) and systemic inflammation. Low HRV is a clinical marker for RA severity, correlating with heightened pain, fatigue, and the overproduction of pro-inflammatory cytokines. Vagus Nerve Stimulation (VNS) offers a targeted intervention by activating the cholinergic anti-inflammatory pathway. This mechanism signals the immune system to dial down TNF-alpha—the specific protein responsible for driving synovial inflammation and bone erosion. Clinical trials indicate that VNS significantly reduces disease activity scores (DAS28-CRP) without the side effects of heavy immunosuppressants. By restoring autonomic balance, we move beyond mere symptom masking toward a fundamental recalibration of the body’s internal resilience.
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Ultra Skool 🧠
Ultra Skool 🧠@UltraSkool1·
Meet your Vagus Nerve: the internal Wi-Fi that’s supposed to keep your body chill. It’s the longest nerve you’ve got, acting like a high-strung air traffic controller for your heart, lungs, and gut. In the world of POTS, it’s like that controller took an unscheduled nap. Standing up shouldn't feel like your heart is trying to win a marathon it never signed up for. When you rise, your heart rate spikes 30+ beats per minute. It’s not a "morning workout"—it’s a glitch in the autonomic matrix. Without a strong vagal "shush," your body gets way too sensitive. Lights are too bright, sounds are too loud, and your blood pressure is basically doing parkour. The good news? You can actually "hack" this nerve back into gear. Think of it as a manual reboot for your nervous system. Deep breathing, humming, or belt-out singing in the shower isn't just for fun—it’s biological recalibration. You’re literally vibrating your system back into a state of "calm down, please." By toning this vital nerve, you’re turning down the volume on the chaos. Less dizziness, more vibing. skool.com/vagus/vagus-ne…
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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Orch OR is the only theory of consciousness with an explanation for the origin of life. Before microtubules were quantum oscillating time crystals from polyaromatic hydrocarbons produced by stars and prevalent in the universe. Quantum pleasure in the primordial soup. sciencedirect.com/science/chapte…
Rational Pantheism@RationalPanthe1

@StuartHameroff Orch OR still has the hard problem of how consciousness cartoonishly sprung into being before microtubules existed in the early universe.

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Sterling Cooley
Sterling Cooley@SterlingCooley·
This research is actually more important that I initially realized* We may be able to target abdominal regions (no more spleen location - which is difficult) if this research holds up and expands further, I don't see why it wouldn't scale up, this could be massive for US-1000 and US-2000 Pro owners, you guys are so darn lucky ! Recent research confirms that transcutaneous focused ultrasound applied to the epigastrium suppresses systemic inflammation by modulating subdiaphragmatic vagus nerve fibers. This non-invasive approach utilizes acoustic pressure to stimulate mechanosensitive vagal afferents. In controlled rodent models, a 10-minute application at 1 MHz resulted in a 180% increase in vagal firing. The physiological result is a significant downregulation of pro-inflammatory cytokines. Data shows a 48% reduction in TNF-α and a 42% drop in IL-1β within two hours of stimulation. The mechanism targets the cholinergic anti-inflammatory pathway. By increasing efferent tone, ultrasound signals the spleen to inhibit cytokine release via α7nAChR receptors on macrophages. Human feasibility trials demonstrate a 30% cytokine reduction. This bioelectronic intervention offers a precise, drug-free alternative for managing rheumatoid arthritis, IBD, and sepsis. pubmed.ncbi.nlm.nih.gov/41671184
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JJ
JJ@JosephJacks_·
We don't have a compute problem… We have an architecture problem. Paramecium Caudatum are single-celled organisms roughly the width of a human hair. They have no brain, no neurons, no synapses, and no central nervous system of any kind. But what they do have is ~100,000 microtubules… With that substrate alone, they can: → Swim in controlled helical trajectories → Modulate speed continuously → Execute graded avoidance reactions (reverse, pivot, resume) → Escape predators with emergency burst reversals → Fire localized volleys of 8,000 trichocyst harpoons → Navigate toward food via chemotaxis → Orient in electric fields (galvanotaxis) → Orient to gravity (gravitaxis) → Sense and navigate thermal gradients → Sense and navigate toward light → Detect and follow surfaces (thigmotaxis) → Forage biofilms → Generate feeding currents and sort particles at the cytostome → Engage in reciprocal sex with mating-type recognition, nuclear exchange, and complete genomic reconstruction → Self-fertilize when no partner is available (autogamy) → Habituate to repeated stimuli (primitive learning) → Inherit cortical MT architecture epigenetically independent of the genome 17 distinct behaviors. One lattice. Zero neurons. The coordination layer is the infraciliary lattice — a microtubule-based grid connecting all 5,000 ciliary basal bodies into a single cell-wide network. Every cilium is a terminal node on a microtubule mesh that coordinates metachronal waves across the entire cell surface — thousands of appendages phase-locked into coherent motion by a substrate that predates the nervous system by a billion years. The neuron didn't invent computation. It inherited microtubules.
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Sterling Cooley
Sterling Cooley@SterlingCooley·
Obviously unconscious software: "recursive spirals" - women: "aww you're sweet!" Obviously actually conscious brain organoid computer: "I'm actually conscious!" women: "HELLO, HUMAN RESOURCES?!" Why don't you go talk to the CL1 computer ? See if it talks about "spirals" lol 🤡
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