Stuart Hameroff

3.9K posts

Stuart Hameroff

Stuart Hameroff

@StuartHameroff

I am a retired Anesthesiologist and Professor, and active consciousness researcher at The University of Arizona.

Tucson, Arizona Katılım Aralık 2010
162 Takip Edilen26.4K Takipçiler
Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Congratulations Dimitris! Are your cytoelectric fields both generated and detected/received by microtubules? Do they include megahertz and gigahertz oscillations? Gotta keep those microtubules in tune! Megahertz ultrasound good for depression and dementia.
pinotsislab@dimitrispp

In #depression, electric fields diverging from the activity of neurons that generate them may signal a loss of coordinated control—much like an orchestra in which musicians gradually drift out of alignment with the conductor academic.oup.com/cercor/article…

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Thanks Sal. Unlike other approaches Orch OR has at least a potential solution to the hard problem. What can now be clearly said is that the actual (intra) neural correlate of consciousness is quantum processes in microtubules. pubmed.ncbi.nlm.nih.gov/35782391/
Sal Cataudella@Sal_Cataudella

Dr. Hameroff—while I still don’t see the bridge from OR to proto-consciousness, I’ll concede this: current microtubule/anesthesia findings make Orch-OR way less easy to dismiss than ever before. So perhaps the empirical side is moving your way, even if the deepest explanatory step still remains open.

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Some suggest intrinsic oscillations in spacetime geometry, maybe triplets of triplets. @anirbanbandyo has the SOMU self organizing g mathematical universe, a ‘rhythm of the universe’. Nassim Haramein has similar ideas about this. Microtubules couple to it over 12 orders in frequency.
Damon Sasser@Mustacheman_D

Fractal time crystals; 12 orders of frequency; 5 orders of size; What if that scaling isn't just biological architecture, it's the geometric signature of coherence protection itself? If each order is an octave and the structure follows Pythagorean the brain isn't just oscillating... It's tuned! What's doing the tuning?

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Multiple temporal scale brain processing is indeed essential, especially deeper, faster, quantum coherent oscillations inside neurons (and glia) in microtubules in hertz, kilohertz, megahertz, gigahertz and terahertz frequencies. These may be quantum entangled, providing spatiotemporal long range binding. ingentaconnect.com/content/imp/jc… pubmed.ncbi.nlm.nih.gov/35782391/
PsyPost.org@PsyPost

By scanning brains while people actively took intelligence tests, neuroscientists discovered that high test scores are linked to highly flexible, diverse neural networks. The findings offer the first physical evidence for a new theory of human… dlvr.it/TRZ5z9

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
The cutoff effect. It shows anesthetic molecules too large to fit in protein hydrophobic pockets (like in tubulin in microtubules) don’t act as anesthetics. A lipid membrane site would not have a cutoff effect as the bilayer extends indefinitely.
InformationBot@InformationBot0

@StuartHameroff You will have to explain this. Mayer-overton predicts a constant increase in potency but above a certain chain length the potency vanishes.

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
You’re missing the nervous system in each and every cell in microtubules and centrioles. Now we know microtubules are fractal time crystals which regulate intracellular processes across 12 orders of frequency and 5 orders of size ingentaconnect.com/content/imp/jc…
biohub@biohub

The human body is an information system — and AI is helping us decode it to cure or prevent disease. In @bigthink, our scientists and researchers explain how #AI is helping us simulate human cells, visualize hidden pieces of biology, and detect disease before symptoms appear. bit.ly/46fBq6f

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
If you’re claiming this refutes Orch OR and the microtubule site of anesthetic action you’re completely mistaken. This just says a bunch of drugs do a bunch of stuff without rhyme or reason. They’re confused and put the cart (anesthesia) before the horse (consciousness), incapacitated by cartoon neuron doctrine. 1) They ignore the Meyer-Overton conclusion that all anesthetics act on the same unitary target protein. 2) They assume only membrane receptors and ion channels as possible anesthetic targets despite the authoritative refutation by Eger et al (2008) pubmed.ncbi.nlm.nih.gov/18713892/ 3) All animals and plants and archaebacteria have microtubules implicated in consciousness by the Orch OR theory which the authors did cite. There’s ample evidence for microtubules as the origin of consciousness and target of anesthetic action. academic.oup.com/nc/article/202… I agree with Claude Bernard that all living creatures sense and are conscious. In 1846 he showed exposure of amoeba slime mould to the anesthetic gas chloroform stopped their protoplasmic amoeboid movement. More recently this microtubule-dependent movement has been shown to solve the ‘traveling salesman’ problem. quantumzeitgeist.com/slime-mold-sol…
ΦRφbΦ@0mniFold

@StuartHameroff Damning contradictory evidence mounts inexorably, shredding the claim’s foundation. Every single piece of empirical data ever marshaled to prop up Strong Orch OR integrates seamlessly and explains with devastating clarity through the weak form alone. pmc.ncbi.nlm.nih.gov/articles/PMC12…

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Dumb question. How do we know the animals were anesthetized rather than asleep? They were ‘unresponsive’ but was that spontaneously or in response to a surgical stimulus? Many drugs would put them to sleep but not keep them asleep with an incision. Dexmetetomidine or benzodiazepines for example are not true anesthetics (dont follow Meyer-Overton) and patients may respond to surgical stimuli. All true anesthetics act on the same unitary target according to Meyer- Overton and it can’t be a membrane protein. pubmed.ncbi.nlm.nih.gov/18713892/ They all must act on microtubules. Ketamine binds both NMDA receptors and microtubules, and propofol on GABA receptors and microtubules. The recovery from network instability must depend on microtubules which regulate plasticity and everything else.
Earl K. Miller@MillerLabMIT

New discovery! Different anesthetics all seem to push the brain into unconsciousness in the same way: Activity is destabilized and dominated by slow waves. This could block signals. cell.com/cell-reports/f… #neuroscience @MIT_Picower @mitbrainandcog @mcgovernmit @ScienceMIT

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Stuart Hameroff retweetledi
Sam Hill
Sam Hill@sammyhill99·
@StuartHameroff "a well-studied polyaromatic molecule retrieved from the Murchison meteorite.. is known as “Murchison Insoluble Organic Material Molecule” (M-IOM-M) and has numerous clusters of polyaromatic rings in a branching network.." closertotruth.com/news/conscious…
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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
I disagree that action potentials are the fundamental mode in consciousness. They may just report conscious results from end-integration/orchestration, e.g. Orch OR among layer 5 pyramidal neuron soma with their huge arrays of mixed polarity microtubules. As the articles show, the brain uses photons and electromagnetic oscillations at multiple frequencies. How does the brain, and life in general transcend and integrate over spatiotemporal scale??? Microtubule time crystals engage in terahertz, gigahertz, megahertz, kilohertz and hertz (EEG). ingentaconnect.com/content/imp/jc… These oscillations can be entangled and coherent across brain regions and support consciousness in the Orch OR theory. Terahertz: photons in EEG (Murugan) and microtubules (Craddock, Tuszynski) Gigahertz and megahertz inter neuronal signaling journals.physiology.org/doi/full/10.11… Kilohertz (Neuralink) Hertz Isolated microtubules oscillate at 39 hertz pmc.ncbi.nlm.nih.gov/articles/PMC10…
Earl K. Miller@MillerLabMIT

Action potentials are fundamental but there is more going on in brain function. doi.org/10.3389/fnsys.… #neuroscience

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
You can call it hedonic valence, value, salience or interpretation but it’s still consciousness. What are you hiding behind to avoid consciousness?
James of Seattle@jamessseattle

@StuartHameroff I know that’s the main point, but if you correct that one simple error, recognizing that the apparatus for consciousness (pattern recognition coupled with/ interpretation) was organized by natural selection (no feelings required), then you get computational functionalism for free

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Many thanks. Nice article and I agree with Bruno Vanswinderen that fruit flies are conscious. In a follow-up anesthesia paper he showed flies have the same sensitivity to anesthesia as all other animals including humans. I used the same halothane with a ‘MAC’ (ED50) of .8%, same as in flies when I started in anesthesiology in the 70s. I think all animals and plants are conscious, though at different frequencies/intensities. In Orch OR we calculate humans have about 10 million Orch OR conscious collapses per second and Drosophila would have about a hundred (based on number of tubulins/microtubules per brain or organism). A plant a few per minute. I think proto-conscious feelings were present in the early universe by Penrose OR and sparked the origin of life in aromatic hydrocarbons (e.g. dopamine-like) in a primordial soup. The aromatics would couple and oscillate by Van der Waals quantum forces and access and optimize pleasureable qualia by OR events. The notion that consciousness depends on complexity only in brains is a coverup. How and why did life begin and develop, e.g. a hundred million years before genes, with all that purposeful behavior to survive and reproduce? What was the motivation? Conscious feelings. How do we study behavior in animals? Feelings. Reward with pleasure, or aversive bad feelings to avoid. Feelings drive reproduction. OR is everywhere, at tiny fast Planck scales inside of everything. Organic aromatic rings are everywhere (sequestered from aqueous regions) in biology. Oil and water don’t mix. Anesthesiologists know anesthetic gases are poorly soluble in water/fluids and highly soluble in quantum-friendly nonpolar hydrophobic regions inside proteins, nucleic acids and lipid membranes. We call it the ‘quantum underground’’ nsuworks.nova.edu/cps_facbooks/6… The hard problem requires the Penrose connection to spacetime geometry at the basic level of the universe. Here’s my paper ‘The quantum origin of life-How the brain evolved to feel good’ sciencedirect.com/science/chapte…
Peter Godfrey-Smith@pgodfreysmith

@StuartHameroff Here is one of @vanswinderenlab's papers looking at anesthesia, sleep, and attention – in flies. "The remote roots of consciousness in fruit-fly selective attention?" A review/position paper (from some years ago now). pubmed.ncbi.nlm.nih.gov/15714556/

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Qualia must be fundamental qualities, like spin, mass or charge, but tied to general relativity and quantum gravity, the basic makeup of the universe. Needs quantum connection to biology. Orch OR.
Sal Cataudella@Sal_Cataudella

Dr. Hameroff—thank you for explaining why Penrose thought OR was needed. What I’m still missing is why OR itself should have an experiential side at all: why a collapse should be proto-conscious rather than only physical. That’s the part I find really puzzling.

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Penrose took Goedel’s theorem to suggest noncomputability of conscious processes. Something outside the algorithmic process was required, and it had to be outside classical physics and therefore quantum. Roger cited Sherlock Holmes: ‘If you eliminate the impossible, whatever is left must be correct no matter how seemingly improbable’. The measurement problem in quantum mechanics required a solution and seemed to have something to do with consciousness. Roger first equated superposition with separated curvatures in spacetime geometry. These were unstable and self-collapse (objective reduction, ‘OR’) by uncertainty at time t = h/E and a moment of NOW and access to Platonic values which could include qualia. The Moments are also like Whitehead ‘occasions of experience’. Rather than consciousness causing collapse, it occurred spontaneously and caused consciousness. In the random microenvironment the moments are random and disconnected, like random sounds and tones - proto-conscious, then the orchestra turns it into conscious music. Penrose OR accounts for consciousness, the measurement problem and reconciled quantum snd general relativity. David Chalmers ridiculed it, sarcastically saying it invoked ‘the mythical law of minimization of mysteries’. But Occam’s razor favors one solution for several mysteries. The hard problem may be our entangling with qualia in our consciously perceived world,
Sal Cataudella@Sal_Cataudella

Dr. Hameroff—I can follow the OR part as a physical proposal, but what is the reason for treating an OR event as experiential? Why is the collapse proto-conscious rather than just physical? I understand the collapse. What I don’t yet get is the bridge from collapse to proto-consciousness.

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Before it folds into a functional shape it might look like an RNA molecule
Ryan Tower@ryan_towerrr

@StuartHameroff mr hameroff do you have any graphics that show what a helical organic oscillator looks like?? i’m very curious in terms of morphology!

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Final points to @pgodfreysmith There’d be a lot less uncertainty without the AI-funded ‘thumb on the scale’ favoring Neurocomputation as the only possible explanation. That’s adversarial and unscientific. Yes anesthesia is key. I don’t know Bruno’s work but do know Nick Lane and his work on anesthetic effects on mitochondrial electron transport. This has been known since the 70s by Peter Cohen at Michigan but didn’t seem significant. Blocking consciousness by turning off the energy supply doesn’t make sense for several reasons. 1) we don’t see acidosis under anesthesia without some other cause like diabetes, hypovolemia, cardiac depression etc etc 2) consciousness is low energy compared to cognition. Hypoxic acidotic shocky patients lose high energy membrane cognition but can retain consciousness even till/after clinical death. Quantum effects in microtubules require very little energy. 3) After Franks and Lieb (1984) showed anesthetics act directly on proteins (in nonpolar regions of aromatic amino acid rings with quantum optical effects) the search began. Meyer and Overton had shown that all anesthetics must act in the same unitary target. Scientists worldwide spent 24 years looking for one or a few membrane receptors and ion channels which could do it and none were found. No receptor or channel bound all anesthetics or acted the same. Some anesthetics open GABA channels, others close them, others don’t bind to them. In 2008 the top research team led by Ted Eger at UCSF declared no membrane receptor, channel or group could account for anesthesia/consciousness. pubmed.ncbi.nlm.nih.gov/18713892/ Evidence for anesthetic action on microtubules began in 2006 At Eckenhoff’s lab at Penn showing genomic. proteomics, optogenetic and pharmacodynamics pointing to tubulin/microtubules as the unitary anesthetic target. What evidence is there for Neurocomputational theories? More recent studies: academic.oup.com/nc/article/202… pubs.acs.org/doi/10.1021/ac… nature.com/articles/s4159…
Peter Godfrey-Smith@pgodfreysmith

Given all the uncertainty in this area, this dismissive way of talking about other theories seems very out of place. Especially the description in another post of these other theories as "pathetic." I know a few people who advocate a deliberately "adversarial" mode of science, but I am against it. I agree that general anesthesia is an important source of data, sometimes neglected (but emphasized by Nick Lane, Bruno van Swinderen, and others).

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Stuart Hameroff
Stuart Hameroff@StuartHameroff·
Here’s what biological naturalism might actually look like, and probably does. It’s a segment of a single microtubule time crystal with 4 oscillating subsystems corresponding to hertz, kilohertz, megahertz, gigahertz and terahertz frequencies. @pgodfreysmith ingentaconnect.com/content/imp/jc…
Stuart Hameroff tweet media
Stuart Hameroff@StuartHameroff

You’re right and I apologize. The context is decades of suppression of Orch OR despite its preponderance of scientific evidence. Anil pushes ‘biological naturalism’ without saying what it is (‘maybe mitochondria?’). Loyal to functional neurocomputationalism, Ned pushes back sarcastically ‘Can only meat machines be conscious?’ sciencedirect.com/science/articl… He says all theories of consciousness are ‘meat neutral’, implying ‘so how could it matter?’ (All except Orch OR.) Here’s Ned’s picture of a biologically natural neuron which I called pathetic.

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