DebG 😷🦠☠️

My Violet & a picture I took of her through a drop of water. She’s that tiny dark spot in the drop & you can see her shadowy form behind the lower one

The Poet’s Narcissus are blooming 💟 and I wanted to share their poetry with you

@drwilliamwallac @threadreaderapp unroll Thank you Dr Wallace 🙏🏽

Most people who take CoQ10 think of it as an antioxidant. It is one. But that is not the most important thing it does. CoQ10 is the only lipid-soluble mobile electron carrier in the inner mitochondrial membrane. The electron transport chain has four protein complexes fixed in the membrane. Complex I accepts electrons from NADH. Complex II accepts them from FADH2. But neither can pass those electrons directly to Complex III. They hand them to CoQ10, which physically shuttles across the lipid bilayer to deliver them. Complex III passes them to cytochrome c, the second mobile carrier, which delivers them to Complex IV. Complex IV reduces oxygen to water. The proton gradient pumped by Complexes I, III, and IV powers ATP synthase to produce ATP. Without CoQ10, the chain breaks between Complex I/II and Complex III. Electrons have nowhere to go. Proton pumping stops. ATP production stalls. This is not an antioxidant function. This is the core mechanism of aerobic energy production. CoQ10 is predominantly synthesized endogenously through the mevalonate pathway, the same pathway that produces cholesterol. HMG-CoA reductase is the rate-limiting enzyme of the pathway. Statins inhibit HMG-CoA reductase. That is how they lower cholesterol. It is also how they lower CoQ10. An updated meta-analysis by Qu et al. (2018) pooled 12 RCTs with 1,776 participants and found statins significantly reduced circulating CoQ10. The reduction was present across statin types, intensities, and durations. Both lipophilic and hydrophilic statins showed the effect, with no significant difference between them. This is consistent with what the biochemistry predicts: the pathway is shared. On top of statin-induced depletion, CoQ10 in human heart tissue declines naturally with age. Kalén et al. (1989) measured CoQ10 concentrations in myocardial tissue and found levels peak around age 20, decline by more than 30% by age 40, and drop approximately 50% by age 80. The organ with the highest energy demand loses half its electron carrier over a lifetime. A 2025 meta-analysis by Kovacic et al. (Journal of Nutritional Science, 7 RCTs, 389 patients) found CoQ10 supplementation significantly reduced statin-associated muscle symptoms measured by pain intensity. This is the most current pooled data on clinical outcomes. One important nuance: while plasma CoQ10 depletion from statins is well established, whether intramuscular CoQ10 drops proportionally is inconsistent. Some studies found no change or even increases in muscle tissue CoQ10 during statin treatment. The plasma reduction may partly reflect reduced LDL particles, which are the primary carriers of CoQ10 in blood. The clinical significance of depletion beyond muscle symptoms remains debated. Roughly 200 million people worldwide take statins. The mevalonate pathway that produces their target also produces the electron carrier their mitochondria depend on. The mechanism is not controversial. The clinical implications are still being debated Sources: pubmed.ncbi.nlm.nih.gov/2779364/ pubmed.ncbi.nlm.nih.gov/30414615/ pubmed.ncbi.nlm.nih.gov/41158831/

Novavax done & done. Of course I had to check with the pharmacist-and it was a good thing-because she had Pfizer in her hand! This, despite the fact that I chose Novavax when booking the appointment & my confirmation email explicitly stated Novavax. Go figure.

The American Lung Association (@LungAssociation) is hosting a 3.5-hour virtual "Clean Air School Symposium" on May 5. (Registration link in next post)

My family are all in S Ca. Only one grandkid still masks and it’s not the pregnant one. There’s nothing I can do about it. I’m just here trying to grow some flowers and food and avoid my maga neighbors if anybody gives a flying fük

The person wearing a mask that you laughed at was trying to tell you this was going to happen.

Such disingenuous bullshit. We knew about phosphorylation and micro clots in 2020. We didn’t have the longterm data but there was a lot of fucking cellular damage that we knew about. We also knew about the fetuses and the kids.

reddit.com/r/ZeroCovidCom… We still don't know the 7 year survival rate of COVID-19.

One of the obvious tells that people aren't behaving rationally about covid, is that very few are curious about how the first wavers are doing? A lot of people don't want to stumble onto information that they might not like.

Driver had his mask on the whole time. Yay for the normalization of masking.

Easy peasy lemon squeezy. Scheduled the vaccine online. Selected Novavax. Confirmed it was the correct vaccine w/ pharmacist. Insurance covered it & they gave me a $5 coupon off of anything at CVS.

Researchers are worried, but not worried enough to tell people #COVIDISAIRBORNE and to #MASKUPINRESPIES because #COVIDISNOTOVER

C O V I D is a VASCULAR VIRUS Mottled skin (livedo reticularis) due to COVID-19 is a net-like, reddish-blue discoloration caused by vascular damage, inflammation, or micro-clots restricting blood flow, confirming its nature as a systemic vascular virus The kids are not okay

One reason I wear a mask is indirectly from watching all those documentaries and films about the AIDS virus. Watching how the government did nothing as people died. We have the answers regarding how Covid spreads (it’s airborne) and I’m not going to ignore them.

I don't care what THEY say about wearing a mask l know for a fact masking works.

There are literally a gazillion reasons to mask to protect oneself from a Covid-19 infection, and yet still I am usually the only one around. Everywhere unless I see a tourist or one of the few CC around. But even besides the masking there is ZERO discussion in society about mitigations outside the CC community. Mass delusion or something. But probably I am seen as the weird one.

8️⃣ If an illness is framed as psychological: Governments don’t need to invest heavily in biomedical research Health systems avoid long-term, costly care commitments Responsibility shifts from institutions to individuals

5️⃣ These are not abstract issues. They map onto a very specific history—especially in neurology—where poorly understood conditions were & are absorbed into psychiatric frameworks.

Long Covid has biomarkers. All the scans, all the tests, all the research. I have been saying for years that presenting Long Covid as a "vague", "mysterious" syndrome "with no biomarkers" was going to lead to it being framed as "psychosomatic". And it's obviously happening