Wei Lab@wisc

@QingchunTong @jflier Congratulations!!

A late update on our recent pub that AgRP neurons do not contribute to DIO or GLP-1R agonism based weight reduction but essential for body temp during nutrient insufficiency, echoing @jflier's earlier finding that leptin is rather a fasting hormone: sciencedirect.com/science/articl…

@xiaoyong_yang Congratulations!! Super Interesting!

Happy to share our new study in #Hepatology (May 1): we uncover how #liver cells "talk" to #immune cells to drive #MASH. Targeting TFF2 with #GalNAc-#siRNA ameliorates disease in vivo—highlighting a promising therapeutic path. Read more: doi.org/10.1097/HEP.00…

@silvirouskin Congratulations!!

Check out super cool new paper we contributed to , I’m calling it “"One SNP refolds a lncRNA and rewrites the rules of stem cell self-renewal.” A new lncRNA called HOTSCRAMBL sits in the HOXA cluster and works as a splicing chaperone — it recruits SRSF2 to help HOXA9 get properly spliced in blood stem cells. A common variant (rs17437411) doesn't destroy the RNA, it refolds it, hiding the SRSF2 binding sites. The result: a dysfunctional decoy that can't scaffold splicing, HOXA9 levels drop, stem cells lose self-renewal, and leukemia growth gets constrained. The variant hits harder than a full knockout because the misfolded RNA actively interferes. It's essentially a built-in genetic brake on blood cancer. Read more: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Huge congratulations to our newest postdoc @mariahcalubag on winning the Outstanding Graduate Student Award!! Excited for all the great metabolism research to come!

We are recruiting one postdoc fellow and one Junior Specialist (for those finishing college and planning to pursue a PhD) in regenerative biology and extreme physiology. scvrb-core.ucsf.edu/~huang/lab/Res… Please spread the news. Interested candidates can email me directly.

Congratulations @Shuke_Xiao and our colleagues Leslie Leinwand @CUBoulder and @DrYongXu1 whose🐍🐍🐍 work is featured on the cover of this month’s @NatMetabolism “Satiating serpents”! @Stanford_ChEMH @StanfordPath

Postdoctoral Researcher positions-Kapahi lab - Buck Institute - 🚀 looking for two postdocs to lead cutting-edge studies on nutrient signaling, senescence, & aging — combining multiple models ( ucsf &Buck) buckinstitute.applytojob.com/apply/PIrfHTGB…

@WalterWChen1 @UTSWMedCenter Congratulations Walter!!

Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in @UTSWMedCenter Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology👶🏻, a very exciting frontier in medicine! #neotwitter

For 40+ years, we’ve known how UCP1 drives thermogenesis—but how UCP1-independent pathways are activated remained unknown. Thrilled to share our @Nature paper, led by Faiz Hussain, uncovering this mechanism: nature.com/articles/s4158…

@kazaklab @Nature Congratulations! Super cool!!

Glycogen ubiquitination for subcellular sorting! Wild nature.com/articles/s4158…

Super useful tool & exciting discovery!!

@skinniderlab Super cool!! Congratulations!

Very happy to share our latest efforts to map the mammalian metabolome, in which we combine large-scale in vivo isotope tracing with biochemical AI to discover several structurally unprecedented and biologically fascinating metabolites: biorxiv.org/content/10.648…

@sophmshi @biorxiv @wysscoray Congratulations Sophia! Super exciting!

New Brain Shuttle Alert! 🧠🚀 We're targeting sugars that coat our brain's blood vessels to deliver therapeutics across the BBB. Preprint now on @bioRxiv (link below), but this is just the beginning. A Bertozzi x @wysscoray x Shi labs collaboration

@WiscoSurgMetab @UWBiochem @Molecules_MDPI Congratulations!!

Excited to share our latest manuscript completed in collaboration with Dr. Snehal Chaudhari @UWBiochem! Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes mdpi.com/3814322 #mdpimolecules via @Molecules_MDPI

@JasonRCantor @guytochondria Congratulations Jason! Super interesting story!

🚨 excited to share our latest preprint, led by the soon-to-be Dr. @guytochondria! We tackle a striking case of conditional dependence on UFMylation, a UBL modification pathway whose contributions to cell fitness have been a bit of a "black box." 🧵 biorxiv.org/content/10.648…

nature.com/articles/s4225… Huge congratulations to my Twitter-less, next-door colleague Snehal for creating this amazing resource on folate metabolism!! How exciting!

@EnginLaboratory Congratulations Feyza!

I’m excited to share that our review article, co-authored with my colleague Dr. Decio Eizirik, is out today in Science Translational Medicine. science.org/doi/10.1126/sc…

@Andy_P_Tsai Congratulations Andy!!

Honored by this recognition from the American Aging Association. Grateful to the mentors, collaborators, and colleagues who have supported me along the way. Excited to keep building work at the intersection of immune resilience, brain aging, and healthy longevity.

The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao! nature.com/articles/s4225…