Judith Simcox PhD

Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…

The Booker Lab at the University of Pennsylvania, in Philadelphia, and HHMI is searching for a lab manager. If interested, please apply at the HHMI link below.hhmi.wd1.myworkdayjobs.com/en-US/External…

For 40+ years, we’ve known how UCP1 drives thermogenesis—but how UCP1-independent pathways are activated remained unknown. Thrilled to share our @Nature paper, led by Faiz Hussain, uncovering this mechanism: nature.com/articles/s4158…

📢🎉@hhmi_science competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA

I am very happy to share that our paper is now published in @Nature 😊 Cell-type-targeted mitochondrial transplantation rescues cell degeneration. nature.com/articles/s4158… @IOB_ch (1/6)

Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat. Read more here: biorxiv.org/content/10.110…

New publication from the lab, led by the talented graduate student @ankurkumar110 , demonstrating that reduced plasmalogen ether lipid biosynthesis may contribute to age-dependent impairments of mitochondrial morphology and membrane dynamics. authors.elsevier.com/a/1mrba3Im5lHaF

Interested in aging and rejuvenation? We have a new Research Assistant position to understand aging at the cellular level!! Come join our team!!! 😎 careersearch.stanford.edu/jobs/life-scie…

Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s4158…

📣 Abstracts are open + registration is live! Join us at the 11th Annual Chicago Mass Spec Day 2026 📅 July 15 | 📍 University of Illinois Chicago 🎓 Posters • Talks • Networking 🔗 chicagomassspecday.weebly.com #2026CMSD #Omics #TeamMassSpec

Another hard-won project from the lab. We've been trying to understand how proteins get into the mitochondrial outer membrane for almost a decade, and hopefully we're finally getting closer. The structure, evolution, and mechanism of MTCH2: biorxiv.org/content/10.648…

🚨 excited to share our latest preprint, led by the soon-to-be Dr. @guytochondria! We tackle a striking case of conditional dependence on UFMylation, a UBL modification pathway whose contributions to cell fitness have been a bit of a "black box." 🧵 biorxiv.org/content/10.648…

Join us in shaping the future of science! @hhmi_science is hiring a new Scientific Program Officer to support the #HannaGrayFellows #FHScholar programs hhmi.wd1.myworkdayjobs.com/en-US/External…

Excited to share our latest manuscript completed in collaboration with Dr. Snehal Chaudhari @UWBiochem! Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes mdpi.com/3814322 #mdpimolecules via @Molecules_MDPI

🚨 New paper out in @NatMetabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇 nature.com/articles/s4225…

主著がCellに出ました！脂肪細胞ミトコンドリアがホスホエノールピルビン酸（PEP）の輸送を介して脂質新生を担うことを示しました。また、ミトコンドリアPEP輸送体としてSLC25A35を同定しました。梶村先生を初め、共著者の方々と、支えてくれた家族に深く感謝いたします。 cell.com/cell/abstract/…

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.648…

1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. nature.com/articles/s4159…

The first paper from the Crewe lab is online today. We found that macrophage-meditated clearance of EVs is a major determinate of circulating adipocyte EV levels. This clearance is disrupted in obesity. A huge effort by Snigdha Tiash! cell.com/cell-metabolis…

2/ We used systematic, parallel CRISPR-based genetic screens in hepatocytes, run across multiple metabolic conditions, to identify regulators of lipid droplet biology. You can access these screens through crisprlipid.org.