WinklerTom retweetledi
A fan catches a ball and gives it to a little kid, then this happens x.com/AllWonderfulVi…
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WinklerTom
276 posts
WinklerTom retweetledi
The impact of age on genetic associations is generally underexplored. An example of a genetic-by-age interaction analysis at the GWAS level🧬📈
👉6 loci for BMI & 26 for pulse pressure
👉probably reflect effects on longitudinal trait change
🔗genomebiology.biomedcentral.com/articles/10.11…
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WinklerTom retweetledi
GWAS is typically run for cross-sectional traits and not longitudinal trait trajectories📈🧬
👉New paper describes an application of linear mixed models for longGWAS of eGFR decline
👉Modeling function of age with random slopes & intercepts was statistically advantageous
link👇
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@minouye271 @gushamilton @MariosGeorgakis Is there some rough estimate on how much CO2 was approx. emmited by such a GWAS? It is a tradeoff indeed
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@EleZeggini @HelmholtzMunich This looks excellent and will be highly beneficial for GWAS folks (especially in the EU). Thanks so much for the effort 👍😀
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Excited to launch the @HelmholtzMunich Imputation Server, enabling genotype imputation within the EU and beyond. Lots of plans for future development, reference panels and functionality enhancement
rdcu.be/d0h3y
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WinklerTom retweetledi
The UK Biobank (UKB) has been an amazing field changing resource for the past decade. Unfortunately, and very suddenly, they have decided that to work with their data you now *must* use their “Research Analysis Platform” (RAP). @uk_biobank I guess there have been general warning
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WinklerTom retweetledi
This Friday is the deadline to register for EMGM 2024 in Vienna (3-4th April). This is a great conference, especially for PhD / postdocs. See more details here emgm2024.ista.ac.at
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WinklerTom retweetledi
The IGES Annual Meeting Call for Abstracts!
Abstract topics
Biobanks & large-scale populations
Common disease genetics
Diversity & studies of multiple ancestries
Immunogenetics & Infectious Disease
Machine learning, artificial intelligence, and data science
1/3 #iges24
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WinklerTom retweetledi
(1/3)🧬💻 Join the Genome Informatics team at the Institute of Genetic Epidemiology, Medical University of Innsbruck @imed_tweets🎓 I am seeking a PhD Student to work together on polygenic risk scores and genetic data analysis 🚀
genepi.i-med.ac.at/theses/genome-…
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WinklerTom retweetledi
IGES 2024!
We will be in Denver November 3-5 for our annual meeting--JOIN US!
More details here:
geneticepi.org/iges-2024-denv…
GIF
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WinklerTom retweetledi
Save the date for the 2024 IGES annual meeting, Nov 3-5, in Denver, just before ASHG.
More info at:
geneticepi.org/iges-2024-denv…
@genepisociety @GeneticsSociety
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WinklerTom retweetledi
⚡️Please, RT: interested in GWAS analyses, their follow-up, PGS or MR? Apply for the Short online live course "Introduction to the statistical analysis of GWAS" by Jan 5, 2024 tinyurl.com/y582m6ud It will be the 10th edition, 450 scientists trained thus far! @UniOfSurrey
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WinklerTom retweetledi
WinklerTom retweetledi
WinklerTom retweetledi
2023 IGES Annual Meeting starts in 9 days! 🧬
Take advantage of activities targeted for early career investigators:
- gathering during welcome reception, Nov 5
- mentoring lunch, Nov 6
- social hour, Nov 7
Please repost, share, advertise.
See you in Nashville!
@genepisociety
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WinklerTom retweetledi
Our GWAS pipeline has been highlighted by @SeqeraLabs. Current features are only the start. Let us know which models you want to see integrated besides REGENIE. We will talk about the pipeline at the @nextflowio summit in 2 weeks. @imed_tweets
Rob Lalonde@HPC_Cloud_Rob
@SeqeraLabs latest “Pipeline In The Spotlight'' is github.com/genepi/nf-gwas, a @nextflowio pipeline to perform biobank-scale genome-wide association studies on HPC or Cloud. Analyze thousands of phenotypes in parallel and explore your final results interactively in a web browser.
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@lcpilling r2=0.6 will yield index variants with varying maf that sit on the same haplotype (high D') that are not independent. r2=0.01 gets rid of them but misses indep associations. The most accurate way will be stepwise conditional forward selection using IPD (or gcta for meta-analysis)
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🧬 #genetics and #bioinformatics friends: a question on clumping variants based on LD
'Easy' to do with R^2. Not seeing much agreement on a threshold for D'. Seen papers that use 0.6 (seems high to me), but 0.1 or lower seems too restrictive. Any thoughts? Thanks ❤️
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WinklerTom retweetledi
The last paper from @covid19_hgi is out in @Nature . Thanks again to all the contributor, for making this initiative a success and for all the friends made on the way ☺️
nature.com/articles/s4158…
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WinklerTom retweetledi
Wir sind zutiefst betroffen und traurig: DZHK-Professorin Jeanette Erdmann ist am 8. Juli 2023 plötzlich verstorben. Sie war eine fabelhafte Wissenschaftlerin und ein wundervoller Mensch. Unser Mitgefühl gilt den Angehörigen. Wir werden sie nie vergessen. 🖤
Jeanette Erdmann@JeanetteErdmann
Jetzt online: Abenteuer Diagnose #59 "Die Forscherin und das Geheimnis der Zebrafische" ist in der ARD Audiothek, auf der Visite-Website und bei Apple Podcasts zu finden. #COL6 @UKSH_KI_HL @UniLuebeck @cardiogenetics @dzhk_germany #DGM 1.ard.de/AD_F59_DieFors…
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