Barked.eth

@DeeevFS Its true! I was there

We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks. + 3 months for baseline measurement + across 4 time points per cycle + doing the same thing every day + a dedicated full-time medical team For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started. The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions. We will try to answer practically useful questions and share all of the data + learnings for free. Can fertility be improved? + Should women cold plunge? + Can PMS symptoms be alleviated? + What should a female sauna protocol be? + Should dosage change throughout the month? + What keeps a cycle regular? + Does the body need more iron, magnesium, or protein at specific phases? + Should women fast? + Should recovery protocol change by phase? + What's the earliest detectable signal of perimenopause? + Can perimenopause be slowed? + How is cognitive load & mood affected? + Does stress impact men and women the same? Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover. Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies. She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is. In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol. Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do. N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women. If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence. It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans. At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly. The beginning of the world’s first n=2.

This is what happens when people use AI frequently and uncritically (don't tell me that I didn't warn you!) *Video by @JoeNunnink and @harrisalterman

@bryan_johnson Arent you actively trying to cool down your average body temperature

3x this week I sat in 200°F (93°C) dry sauna for 55 min to get my core body temp to 102.4°F (39°C) That temp, at that duration, triggers primal panic. Took blood samples before and after each session to measure heat shock protein expression. Sauna is one of the world's best longevity therapies. What we don't know is whether hitting the core temp threshold unlocks a meaningfully superior response or whether the benefits are more fundamental: vascular shear stress, nitric oxide release, sweating. Most people doing sauna never reach 102.4°F. That's high-grade fever territory. I'm excited to see the data.

@bryan_johnson You should listen to the podcast Dr Rhonda Patrick put out on sauna. According to her data that is too high of a temperature, and the greatest benefits are derived from sub 200° f, and actually negative and detrimental effects above it.

JUST IN: $760,000,000 worth of oil shorts were reportedly placed 20 minutes before President Trump announced the Strait of Hormuz was open.

Dollars to donuts, California is going to have slingshot magazine capacity laws after this. This is a single action slingshot 👀

@SoveyX What was the point of painting the outside

I did not expect it to turn into this.

@PalmerLuckey Go all in and if your wrong quit twitter

Let's raise the stakes and go All-in. If Jason lied about visiting the island, he resigns from the podcast. If not, I move on and never again bring up his name, words, or deeds.

I went back to Ibiza

lmao, I know some men in this situation 🤣

The ‘Great Noticing’ Continues

This nerd got STD's from Russian hookers and had to spike his former wife's martini with Doxycycline

Maybe I’m missing something here but it is a bit mental to me that a group of the highest profile people in the world got together and said ‘lets all go to an island and have child rape parties and then also let’s remember to continually document loads of blatant and insanely incriminating evidence of it’

guys i’m now safe and we got the cat on the protocol

@thebeaconsignal @sama Its much more complicated than that, you missed the 🎯

i helped turn the thing you left for dead into what should be the largest non-profit ever. you know as well as anyone a structure like what openai has now is required to make that happen.

that is assault…! Press charges.

The woman who was brutally attacked in Vancouver STILL voted for the Liberals AFTER her attack. She responds here nonchalantly to attacker getting released too. If an attack of this magnitude can't make you vote for change in law reform, nothing will. I've suddenly lost sympathy for her. #LiberalismIsAMentalDisorder #LiberalsMustGo

@iluminatibot No such thing, currently in china traveled the entire country nothing like thjs

In China, citizens require biometric digital ID (verified by facial recognition cameras) to leave their neighbourhood zones. This girl keeps failing the facial verification process, so she is unable to leave her zone. Coming to the West soon, if we allow it.