Yang Wu

@elezzx2020 Thanks! The Pi parameter is estimated by counting how many loci with a gene associated with complex trait in the genome (we formulate this in a Bayesian way). It is a global parameter across all genes but restricted to one tissue/cell type.

@YangWu20 Very impressive work! Can you explain more on how the Pi parameter is estimated for eQTL data? Is it a global parameter across all genes and cell types? Thanks!

Thrilled to share our latest work! We have generalized the SMR&HEIDI approach to a multi-omics model, which links ~50% GWAS loci to 7 types of molecular phenotypes genetically. cell.com/cell-genomics/…

💫ONLINE NOW @AJHGNews 📰 Impact of cross-ancestry genetic architecture on GWASs in admixed populations 🧑‍🤝‍🧑@bpasaniuc @hennlab & team 👇 bit.ly/434MCiC

Join us at our 2nd Genetics & Genomics Winter School in Brisbane, Australia, from June 19-23! This week-long course is open to participants from all over the world. Register now and get more information at hsu.imb.uq.edu.au/genetics-and-g… @PCTGenomics @IMBatUQ

Delighted to share our latest research in @GenomeBiology investigating the application of latent variables in sc-eQTL modeling (pseudo-bulk level). We observed spurious correlations among inferred latent variables which compromise the power genomebiology.biomedcentral.com/articles/10.11… 1/n 🧵

Fancy spending a few years working down under in sunny Australia doing statistical genetics? I'm offering two postdoctoral positions for up to four years- seek.com.au/job/60847315 Feel free to DM me if interested!

Excited to see our new paper published in @AJHGNews. We release R package r2redux that allows formal statistical comparison of two polygenic score models, providing the 95% confidence interval and significance of R2 difference. authors.elsevier.com/c/1gUCageX6KJk…

PhD position in Adelaide, @ACPreH1, @BBenyamin1, unisa.edu.au/research/degre…

We are recruiting a postdoc at Level A or B with interest in statistical genetic analysis and method development using multi-ancestry GWAS data and functional genomic annotations. Apply online at uq.wd3.myworkdayjobs.com/uqcareers/job/… Closing date due in 3 weeks. Visa sponsorship available!

Check out our new method SBayesRC for polygenic prediction. We extended SBayesR to consider functional annotations and all imputed common SNPs. We found improved accuracy for within and cross ancestry prediction and a major contribution from evolutionary constrained regions ◦

New preprint! We demonstrate that PGS accuracy varies continuously cross individuals within and across genetic ancestry clusters and highlight that PGS should be interpreted through the lens of continuous genetic ancestries. 🧵 biorxiv.org/content/10.110…

imb.uq.edu.au/Covid-OZGeneti… Recruiting anyone in Australia who has tested positive for COVID19. We are trying to capture the variation between people in symptoms from very mild to very severe and link that to DNA and/or antibody differences. #covidozgenetics #covid #naomiwray #imb.

Whole genome sequences of 1739 Asians representing 219 population groups in 64 countries. Massive effort. It's great that they've deposited the reference genomes in Michigan imputation server for anyone interested in Asian specific imputation. #Sec6" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…