Yannick Buccella MD

March is Colorectal Cancer Awareness Month. As a GI oncologist, there’s something I wish everyone understood: Many of the patients I see with colon cancer never thought they were at risk. Some are in their 40s. Some even younger. Here’s what everyone should know 👇

@forallcurious HIFU has been done for a long time now, especially in less aggressive prostate cancer. It’s not a procedure for every patient, but a good tool for the right case.

🚨: FDA approves cancer treatment using sound waves instead of Chemotherapy, radiation, or surgical procedures

@Whiplash437 This is no clinical trial by the way. There is absolutely zero data that this works. In the only small trials as a stand alone treatment we have seen, there was zero response. These drugs don’t work as a cancer treatment.

CANCER HAS BEEN CURED Ivermectin & Fenbendazole cure cancer. Pass it on. BREAKING NEWS: First-in-the-World Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024! The future of Cancer Treatment starts NOW. My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr.Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life. I hope that this peer-reviewed paper lays the groundwork for a brand new future for Cancer Treatment. Many of you know that I have been helping thousands of Cancer patients with high dose Ivermectin, Mebendazole, and Fenbendazole

@BBMagaMom It doesn’t work, it only works in the lab with for humans unrealistic dosages. The only times it was tried in humans - like here with mebendazole - if failed.

🚨Peer-reviewed studies are now documenting complete remissions of Stage IV cancers using anti-parasitics. Hundreds of papers show ivermectin and fenbendazole hit over 12 unique anti-cancer pathways across 12+ different cancer types. 🤯

While I also think combinations will be the way in targeting KRAS, toxicity remains a huge issue. The broader you hit the KRAS pathway the more toxicity you cause, especially on the skin. In early trials in humans we have seen pretty bad skin damage, so finding the right dose will be key here.

Pancreatic cancer ranks among the most lethal cancers, with tumors often developing rapid resistance to therapies, contributing to dismal long-term outcomes. In a major preclinical advance, scientists at Spain’s National Cancer Research Centre (CNIO), led by Mariano Barbacid, have shown that a triple-drug combination can completely eliminate pancreatic tumors in mouse models while preventing resistance from emerging. The treatment targets the KRAS signaling pathway—mutated in about 90% of pancreatic ductal adenocarcinomas—at three separate points, effectively blocking the cancer's ability to adapt and survive. The regimen combines daraxonrasib (an experimental KRAS inhibitor, also known as RMC-6236), afatinib (an approved EGFR/HER2 inhibitor used in certain lung cancers), and SD36 (a selective STAT3 protein degrader). This multi-pronged attack shuts down key downstream, upstream, and parallel pathways that KRAS relies on for tumor growth and evasion of single-agent therapies. Tested across multiple orthotopic mouse models of pancreatic ductal adenocarcinoma (including those with KRAS/TP53 mutations), the combination induced complete and durable tumor regression, with no detectable cancer recurrence even months after treatment ended and no major toxicities observed. In some cases, tumors vanished entirely, leaving no trace. While single KRAS inhibitors show promise, resistance typically develops quickly as tumors activate bypass mechanisms. By hitting three independent nodes simultaneously, this strategy overcomes that hurdle in animals, offering a blueprint for more effective targeted therapies. Pancreatic cancer's five-year survival rate remains under 10%, underscoring the urgency of such innovations. Although human trials are not yet feasible and further optimization is needed to translate these results to patients, the study represents a landmark step toward making one of the deadliest cancers potentially controllable. [Liaki, V., Barrambana, S., Guerra, C., Barbacid, M., et al. (2025). A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance. Proceedings of the National Academy of Sciences, 122(49), e2523039122. DOI: 10.1073/pnas.2523039122]

@BradC_84 @stella_immanuel True that these new treatments are not possible for everyone yet, but there is hard work being done all over the world in order to change that. And as much as we want to go away from chemo, one definitely must not forget that you see great results with chemo as well.

@YannickBuccella @stella_immanuel How do we move towards the more effective personalized treatment at a faster pace? I am going to one of the largest cancer centers in the world and they are still using chemo and outdated treatments. Immunotherapy is still not an option for all patients.

Yep. Chemotherapy kills more people than the cancer itself. And most oncologist know that but they do it anyway. Why?

@sciencegirl Not to be a downer here, but radiation using protons has been done since the 1960s. Hence I would be a bit careful with using the term „revolutionizes“. It has been doing so for 60 years now.

Proton therapy revolutionizes cancer treatment with proton beams that stop precisely at the tumor.

You just don’t know what you’re talking about. In 2023 11 people with psychiatric conditions did go down that route, but they had to have many years of adequate treatment without any success, 2 approvals of 2 different psychiatrists and a 3rd one a month before their assisted suicide. You can’t just willy nilly go there and register, because the first treatment failed. But sure, it’s definitely better to let these people jump down a bridge and traumatize some bystanders, thus creating the next patients.

@YannickBuccella @fleurmeston What about the people your country kills who are just depressed? What about the people who travel there to die on forged documents, with their family being entirely unaware? You are disingenuous to suggest that most people are as you describe. Shame on you and your kind.

In case you didn’t hear, Scotland has voted NO to assisted suicide!!!!!!!!!🏴󠁧󠁢󠁳󠁣󠁴󠁿🍾

Why don’t you go and tell that to a patient‘s face, whose bone metastases have grown into the spine and cause excruciating pain as well as paralysis of all body parts below the metastasis without any further treatment option? Or to a patient with an advanced peritoneal carcinomatosis, who vomit their own stool? Tell them, they should go on living, I’d love to see that.

@YannickBuccella @fleurmeston Your country sucks so much, stop killing people who can go on living

@TermitoBostero Fasting as a stand alone treatment didn’t work for him, it won’t work for anybody else. It’s not that simple, the body needs a certain amount of sugar to work.

Entonces una posible cura del cáncer puede ser no comer o estoy gagá?

The specific case is obviously bad, but it’s still her choice? And this shouldn’t deprive other patients, who are terminally ill, from their option to put an end to their suffering. It’s a controversial topic, but I believe that people should decide for themselves when their lives end. And not the underlying disease.

@YannickBuccella @fleurmeston My point is it's becoming a knee-jerk reaction to offer somebody MAiD. Why didn't the govt get that woman into proper housing? Because she was a net financial drain as she had medical issues that didn't allow her to work, so it was cheaper to kill her.

What’s your point here? It’s always a decision made by the patient, which has to be checked by the doctor, who is most aware of the case and will then be checked again by the organization. I’m obviously not aware of the details of the process in Canada, but I can’t imagine anybody forces you to commit assisted suicide. And it that case (which by the way was more than 3 years ago) everybody acknowledged that something went terribly wrong.

@YannickBuccella @fleurmeston And rather than give this veteran a wheelchair ramp, she was offered MAiD. cbc.ca/news/politics/…

@AdamRochussen Well, there goes that hypothesis 😄

@YannickBuccella 😂 yup good point. It was 31 vegetarian cases of oesophageal SCC. 22 of those were never-smokers.

Big headlines the other week about this huge (1.8 million people, 3 continents! Wow!) study out of Oxford looking at the effect of different diets on cancer risk. Vegetarianism cures cancer!!! Just one problem. That's not what the data show. The study (nature.com/articles/s4141…) makes it's big claims based on unadjusted p-values (that aren't even numerically reported anywhere in the main paper). But as anyone with a brain knows, performing 80 different hypothesis tests is bound to produce some false positives. The authors adjust for false discoveries, but don't really take it into account when discussing their data. They also perform sensitivity analysis, but again ignore the findings when discussing their results. Journalists then picked up the narrative-convenient "significant" findings (while simultaneously ignoring inconvenient significant findings): BBC, Sky News, The Independent all reported the same claim: "A vegetarian diet can slash the risk of five types of cancer by as much as 30%, a new study has found.” Okay. But of the original 11 nominally significant findings in study, which made it through both multiple comparisons adjustment and sensitivity analysis? Just the one. Which one? Risk of oesophageal squamous cell carcinoma in vegetarians versus meat eaters. HR=1.93 (95% CI: 1.30-2.87). Yup.

@AdamRochussen Or just a very small sample size. I can’t really imagine that there is a sufficient patients number with squamous cell carcinoma of the esophagus who are never smokers AND vegetarians. That sounds like flying unicorns to me.

@YannickBuccella Apparently they adjusted for smoking and alcohol as covariates… Also the oesophageal SCC in vegetarians remained significant when only including never-smokers. I agree with you it’s odd though. Could be acidic vegetarian foods. Could just be erroneous stats.

CRC: DOI: 10.1056/NEJMra2200869 Brust: doi.org/10.1016/j.brea… Erstens gibt es die Zahlen noch nicht, da hat es immer eine Verzögerung von 3-4 Jahren und zweitens: Wieso soll das der entscheidende Bereich sein? Der Trend geht schon viel länger als es die Impfung gibt, das ist doch der Punkt hier?

@YannickBuccella @MonikaGruber24 bitte nennen Sie den Link zu der Arbeit- ist es diese ? . das die Abb. nur bis 2020 bzw. 2015 gehen fehlt der entscheidene Bereich

Ich hetze gegen niemanden. Ich sehe nur im Bekanntenkreis, dass die Impfung verheerende Auswirkungen auf die Gesundheit meiner Mitmenschen hat: Viele erkranken schwer, leiden an Turbokrebs und auch an Long Covid. Diese Menschen sind alle geimpft und sie und ihre Angehörigen leiden. Wo bleibt Ihr Mitgefühl?

Wie halten Sie denn objektiv gesehen einen „aggressiven hochmalignen Tumor“ anno 2023 - also einen Turbokrebs angeblich durch die Corona-Impfung ausgelöst in Ihrem Sprech - von einem „aggressiven hochmalignen Tumor“ anno 2019 - also kein Turbokrebs, da noch keine Impfung - auseinander? Was sind die objektiven Kriterien, die ihn zum „Turbokrebs“ machen? Also genetisches Profil? Ki67-Cutoff? Irgendwas?

Es. Gibt. Turbokrebs. Durch. Die. Impfung. Gegen. Corona. Gruselig dieses Niveau von @Der_Schalck_666. Unabhängig davon, das der Schalki nicht im Stoff steht, heißt Turbo nichts anderes als "schnell wachsende Tumore = Karzinome" Dieser Ausdruck wurde für Laien eingeführt, da Begriffe wie "Aggressive Tumor, Hochmaligne Tumore, Invasive Tumor oder Grad 3- Tumore/ Grad-4-Tumore, Anaplastische Tumor oder WHO Grad III oder IV selten gut verstanden werden und auf Schalk-Niveau wohl offensichtlich gar nicht. Erschreckend ist, dass die Arbeit in Cells diesen trend sogar noch indirekt bestätigt cell.com/cell/abstract/… Die Grundlagenwissenschaftler suchen nach Krebsentwicklungen im Zusammenhand mit Corona und werten die Jahre 2020 und 2021 aus. 2021 ist bekanntermaßen gekennzeichnet durch Impfunge. Mehr als 70% der Bevölkerung wird mit modRNA-LPG-Gemisch gegen Corona geimpft Und, das Erschreckende, die Karzinomzahlen steigen 2022 statistisch relevant an. In den EHR-Daten wurde keine saubere Trennung vorgenommen zwischen: Gruppe A: Infektion 2020 → längeres Follow-up Gruppe B: Infektion 2021 → deutlich kürzeres Follow-up Stattdessen wurde folgender Ansatz gewählt: Startpunkt: Hospitalisierung wegen COVID danach zeitabhängiges Follow-up Vergleich mit Kontrollgruppe Berechnung von Hazard Ratios Damit ergeben sich sehr unterschiedliche Beobachtungszeiträume: 👉 im längsten Fall etwa 2 Jahre 👉 im kürzesten Fall nur wenige Wochen kann im längsten Fall über 2 Jahre die Krebsentwicklung gehen und im kürzesten Fall nur über wenigen Wochen. Das spricht entweder für einen schnellen Verlauf (TURBO) oder für eine Falschinterpretation der Daten, da das erfasste Karzinom schon vorher (unentdeckt) vorhanden war. Dennoch bleibt die Frage, inwieweit die Impfung oder auch der "Pandemie-Stress" ein Trigger des Ausbruchs waren. Damit hat die Arbeit ungewollt eine Fragestellung aufgeworfen, die bereits in anderen Artikeln (Südkorea, Japan, Italien - Studien) angesprochen wird : Karzinome nehmen dramatisch zu und, das besonders nach der C-Vaccination. ncbi.nlm.nih.gov/core/lw/2.0/ht… Daher ist zwingend zu klären, ob es sich um einen immanenten Part der Impfung handelt, wie von McKernan, Speicher, Rose untersucht oder um einen Brandverstärker im Sinne des Triggerns von Bestehendem handelt oder andere Einflüsse Karcinome post covid-vaccine deutlich ansteigen lassen. Daher ist "Der Schalk" aufzufordern, seine beleidigenden Zurufe an Monika Gruber sofort unter Entschuldigung dafür zurückzunehmen.

As an oncologist I love that! I always appreciate, when patients come prepared, ask deep questions and I don’t have to spoonfeed them every information. Of course you can’t expect that from every single patient, but I would definitely argue that this only helps the HCP-patient-relationship, since there are definitely less misunderstandings and in general information missed or poorly explained. All the best to your dad!

As some of you know, my dad has been fighting lung cancer for the past 2 years. If any of you have any experience with the medical system, you know that the family/patient have to be aggressive advocates. Doctors have a lot of patients and, as much as I’m sure they’d like to, don’t have infinite time. It’s been pretty amazing to see how AI has enabled my mom to be an advocate by translating medical terminology and explaining complex issues. Definitely makes things a lot easier and has made the entire process more manageable. Whenever we get a new test result, she puts it into chat GPT or Claude and (especially now that it has memory) it updates her on what’s going on. Incredibly helpful and really has maximized the communication with his team.

Sehen wir in der Onkologie leider tagtäglich, wie das verfangen kann: Ivermectin, Mebendazol/Fenbendazol, Turbokrebs als Folge von COVID-Impfung, Heilfasten, Biopsien vermeiden, um den Tumor nicht zu verbreiten, etc. Nur um die größten Klassiker zu nennen, die mit seriöser Wissenschaft rein gar nichts mehr am Hut haben. Das darf tatsächlich nicht unwidersprochen bleiben.

Nicht nur in der Pandemie war „Telegram-Medizin“ lebensgefährlich. Das Beispiel „Germanische Neue Medizin“ zeigt wie mit pseudowissenschaftlichem Geschwurbel gezielt Angst ausgenutzt und an der Gesundheit von Menschen verdient wird. Sollten wir nicht schulterzuckend hinnehmen.