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Yin Shen
329 posts
Yin Shen
@YinShenLab
Professor @ UCSF l Functional genomics: gene regulation in 3D, CRISPR screens, and neuroepigneomics l Opinions are my own.
UCSF Katılım Temmuz 2020
281 Takip Edilen1.1K Takipçiler
Launched today- the Weill Cancer Hub West -supporting transformative cancer research collaborations btw @UCSF & @Stanford. Honored to co-lead, with @longlabstanford, our team who will study the impact of diet on pancreatic cancer initiation, progression and therapy response.
UC San Francisco@UCSF
Backed by a $100M gift from Joan and Sandy Weill, UCSF and @StanfordMed @StanfordCancer are launching Weill Cancer Hub West, a $200M initiative in team science to accelerate cancer research and improve care over the next decade. tiny.ucsf.edu/ppVRqt
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Yin Shen retweetledi
🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/45dN5Ck
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
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Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158…
full text available here 👉 rdcu.be/em0VG and thread 👇
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Excited to see our work on HARs highlighted by @TrendsGenetics—appreciate the feature!
Trends in Genetics@TrendsGenetics
The impact of human accelerated regions on neuronal development dlvr.it/TJzWfr
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Yin Shen retweetledi
How did we evolve brains capable of learning and complex language? @IHG_at_UCSF found that parts of our DNA evolved at hyperspeed, making our brains more complex than apes’, but possibly raising the risk of human brain disorders. tiny.ucsf.edu/ZySms3
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Our latest research on human accelerated regions has just been published with @SpringerNature rdcu.be/ebo7a. Congratulations to @MarkTransposon @HanYang_Henry and the team! In this study, we characterize genome variants to function through the lens of evolution.
Xiekui Cui@MarkTransposon
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s4158…. 1/12
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Yin Shen retweetledi
🌟 SAVE THE DATE! 🌟
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is returning with its 4th edition! 🎉
Join us for this incredible event, chaired by Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT), in beautiful sunny St Julians, Malta! ☀️
💥 Save the date and stay updated on all the details!
👉 Sign up for updates by clicking here: bit.ly/41ibKUS
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Yin Shen retweetledi
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.110…
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Yin Shen retweetledi
@JianXuLab @JunhuaLyu @GuZhimin @YuannyuZhang @MinNiLab_stjude @RJDLab @CRI_UTSW @LilyHuangLab @NIDDKgov @StJudeResearch Congratulations, Jian!
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Congrats to the first authors @JunhuaLyu @GuZhimin @YuannyuZhang, and @MinNiLab_stjude for co-leading this project. We thank @RJDLab @CRI_UTSW @LilyHuangLab for collaborations, many other collaborators, and support from @NIDDKgov @StJudeResearch.
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Excited to share our latest work: A glutamine metabolic switch supports erythropoiesis, published today @ScienceMagazine
science.org/doi/10.1126/sc…
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Yin Shen retweetledi
Join us on Nov 18 at @UCSF for the QBI Chromatin Symposium, led by Drs. Vijay Ramani & Yin Shen. This event will showcase the latest in chromatin regulation, from bench to bedside. We look forward to seeing you there next week!
Register now: qbi.ucsf.edu/qbi-chromatin-…
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New @ENCODE_NIH preprint from the lab! Through CRISPR screens, we identify functional enhancers for neuropsychiatric disease risk genes in iPSC-derived neurons. We revealed an exciting allelic compensation effect (ACE) on transcription for the dosage-sensitive gene SIN3A.
Xingjie Ren@Xingjie_Ren
We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.110… 1/20
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when an enhancer is disrupted on one allele, how might genes dosage compensate? this work from my new lab neighbors @Xingjie_Ren @YinShenLab provides interesting insights
Xingjie Ren@Xingjie_Ren
We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.110… 1/20
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@Katz_Lab @emorygmb @angalus_d @BrainJZhou Thank you for the invitation. It was a pleasure meeting with the students and faculty at Emory. The GMB class model is truly unique—I wish I had experienced a course like that during my graduate studies.
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It was great to host @YinShenLab for a seminar and to sit in on class with the @emorygmb students. Amazing what we learn when writing truly functionally characterize GWAS variants. @angalus_d @BrainJZhou
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We identified Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease and validated it by CRISPR from @YinShenLab Thanks @NIHAging @CCLRI @YinShenLab alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
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So wonderful to co-host the newly minted Full Professor Shen @YinShenLab as our invited @YaleGenetics departmental seminar speaker yesterday. Such great talk and groundbreaking science. Thank you Yin for inspiring us!
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