KerenYizhakLab

💻 Code: github.com/yizhak-lab-ccg… 📚 Docs: scxpand.readthedocs.io #MachineLearning #scRNAseq #scTCRseq #CancerResearch #Bioinformatics #bioRxiv

🚀 New preprint! scXpand — the first ML framework to detect T-cell clonal expansion from scRNA-seq (no TCR needed). Built on 2.6M T cells, robust across cancers & TME contexts. 👏 Led by Ofir Shorer & @RonAmit5 🔗 doi.org/10.1101/2025.0…

📢 Excited to share our new paper in @CellGenomics! We analyzed matched #scRNAseq and #scTCRseq from 767K T cells to uncover clonal programs that predict response to immune checkpoint inhibitors. 👉 cell.com/cell-genomics/… #CancerImmunotherapy

📢 Excited to share our new paper in #npjPrecisionOncology: We present a roadmap for using #scRNAseq and #MachineLearning to study and predict response to immune checkpoint inhibitors. 👉 nature.com/articles/s4169… #CancerImmunotherapy

מזמינים אתכם/ן ליום הפתוח למסלול החדש לתואר שני עם התמחות ברפואה חישובית בפקולטה לרפואה בטכניון! 20.3, בשעה 16:00 . לפרטים נוספים : compmed.net.technion.ac.il להרשמה ליום הפתוח: did.li/n8e6q נתראה!

🚨 New preprint alert! We performed scRNA-seq & scTCR meta-analysis on cancer patients treated with ICIs, revealing key T cell signatures linked to therapeutic response, with insights into clonal replacement vs reinvigoration! #scRNAseq #Immunotherapy biorxiv.org/content/10.110…

We are excited to share the agenda for our 1st annual event, 26/9 @ELSCbrain🪅 w/ spotlights 🔦@YOrenLab, Amos Tanay, @yizhaklab, @atownfool & @SItzkovitz. A field overview by @mor_nitzan & @naomi_habib, and sc-ience sessions led by @bitonm, Oren Ram, @YosefLab & @OCohenlab

I’m happy to share our new paper showing moonlighting function of ASS1 in the nucleus. Under the tough circumstances we are facing this paper would have never been published without the help of a wonderful editor, great collaborators and resilient students. Thank you all! ♥️

We celebrate the much-deserved selection of @gaddyg to this year’s class of 2024 AACR Academy Fellows!! Congrats, Gaddy 🎉! aacr.org/about-the-aacr… @MGHCancerCenter @broadinstitute

My second cousin Yagev Buchshtab was kidnapped on October 7 and is being held in Gaza for 81 days now. Please listen to his sister Nufar and share.

We are thrilled to announce that OncoHost has been named one of the Top 10 Precision Oncology Solutions Companies of 2023 by @HealthCareTO! 🏆 Thank you for this honor 💙 Read more: bit.ly/4a4BjdT #PrecisionOncology #HealthcareInnovation #CancerResearch #Proteomics

Happy to share this work lead by Daniel Schaffer, using a deep learning model to identify microbial RNAseq reads that are assembled into longer contigs. We find that the presence of several microbial genes strongly predicts outcomes in esophageal cancer nature.com/articles/s4370…

נעם דן, ממשפחתם של סהר וארז קלדרון ששוחררו אך אביהם עופר עדיין חטוף, טלטלה אתמול את אולפן חדשות 12. הנה שוב קטע מדבריה, עם כתוביות. לצפות, להפיץ לכל עבר

In these darkest days our country have ever known, we somehow manage to do science. Our new paper shows how #metabolism of immune cells predicts patients response to ICI. Ofir finished this paper while in reserve duty helping to bring our people back home cell.com/iscience/fullt…

הסרט הזה הוא חובה אזרחית - אין פה חומרים מזעזעים ורגישים - כנסו להקשיב לכרמית שאביה נרצח, אמה נחטפה ואחיה נעדר

An Open Letter to Every Parent In America Please help me get this message out to every parent in the United States. Please help me protect your children. I am BEGGING you - "liking" this is not enough. Please retweet right NOW. youtube.com/watch?v=uo7fdx…

Before we have to pay to tweet, I want to post an opening for a PhD position at the Weizmann Institute for a student interested in characterizing the tumor MACROenvironment for therapeutic implications.

@YosefMaruvka Highly recommended!

Check out our new #preprint on the metabolism of immune cells in the TME of patients treated with #immunotherapy led by Ofir Shorer. We analyzed scRNA-seq from >1M cells and found a metabolic signature predictive of response across cancer types. biorxiv.org/content/10.110…

We had a great time at the #ILANIT2023 meeting. Very proud of my team with 4 talks, 3 posters, 3 runners and one fun lab outing which as usual, we forgot to take a photo of.