Moshe Biton

Excited to share our new paper in Nature Immunology! 🦠🔬 nature.com/articles/s4159… We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection. A huge thanks to all collaborators and team members who made this work possible!

Feeling truly grateful for all the warm comments, support, and retweets from colleagues, friends, and the broader community. It really means a lot to us and to everyone involved in the study. 🙏🦠🔬. Stem cells rock!

Excited to share our new paper in Nature Immunology! 🦠🔬 nature.com/articles/s4159… We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection. A huge thanks to all collaborators and team members who made this work possible!

🧵 It’s out 📑 What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue? Our paper follows bacterial invasion at single-cell resolution nature.com/articles/s4159… @NatImmunol 1/

We show that stem cells are directly invaded by the pathogen and respond by activating inflammasome signaling, triggering cellular remodeling toward cells with antimicrobial properties. This early epithelial defense program helps protect the tissue at early infection time points.

Excited to share our new @biorxivpreprint from the lab! We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense. biorxiv.org/content/10.648…

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens. doi.org/10.64898/2026.…

Epithelial MHC II antigen presentation dynamically informs intestinal homeostasis and injury biorxiv.org/content/10.648… #biorxiv_immuno

How we’re rebuilding the Weizmann Institute — and our hopes for a better future nature.com/articles/d4158…

Proud to see this study from our @bitonslab in collaboration with @LabSagi now on @biorxivpreprint! Brilliant work by the team, congrats!

Out now in @Science! We and the @KuchrooLab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity. science.org/doi/10.1126/sc…

האוניברסיטה העברית גאה לברך את פרופ' ינון בן-נריה מהפקולטה לרפואה על זכייתו בפרס ישראל בתחום חקר הרפואה, על פועלו בחקר מחלת הסרטן. ועדת הפרס ציינה בנימוקיה כי "פרופ' בן-נריה הוא חוקר פורץ דרך בתחום חקר מחלת הסרטן, שגילה מנגנונים להתפתחות הסרטן שהובילו ועדיין מובילים ליצירת תרופות לטיפול במחלה. מחקריו של בן נריה התפרסמו בבמות מדעיות ובעיתונות המקצועית הטובה והאיכותית ביותר בעולם". בין התרומות של פרופ' בן-נריה לחקר הסרטן נמנים זיהוי הגורם המולקולרי הראשון המסביר את הקשר בין דלקת וסרטן, גילוי דלקת סמויה הנפוצה בתאים סרטניים ומזרזת התפתחות סרטן בנוכחות מוטציות סרטניות, ואפיון גנים המשחקים תפקיד מפתח בסרטן המעי הגס.ל בין התרומות של פרופ' בן-נריה לחקר הסרטן נמנים זיהוי הגורם המולקולרי הראשון המסביר את הקשר בין דלקת וסרטן, גילוי דלקת סמויה הנפוצה בתאים סרטניים ומזרזת התפתחות סרטן בנוכחות מוטציות סרטניות, ואפיון גנים המשחקים תפקיד מפתח בסרטן המעי הגס. צילום: Bruno Charbit

🙌Excited to share that our PI Vijay Kuchroo will be awarded the 2025 AAI-Thermo Fisher Meritorious Career Award, for outstanding research contributions to immunology. Vijay will be presented the award & giving a lecture in Honolulu at the annual @ImmunologyAAI meeting in May.

1/ Keen to share the story of my postdoc research in @TheXavierLab! We built a massive resource characterizing the spatial landscape of the gut, and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇 nature.com/articles/s4158…

Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! nature.com/articles/s4158… rdcu.be/dYAVK. A 🧵

This paper exemplifies the power of @MSKCancerCenter and why I love working here. Access to unique tumor samples, more importantly brilliant physician scientists and most important driven and talented trainees to make it all happen. Kudus to @andrewrmoorman and @elliebenitez11

@leeat_keren Congrats!

Preprint alert! A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology biorxiv.org/cgi/content/sh…. We examined how immune cells are organized in the gut and what happens to them in GVHD. TL;DR Timing is key!

@leeat_keren @SachaLEBON @matanhofree Thanks!

@bitonm @SachaLEBON @matanhofree Congratulations! Can't wait to read it.

Our latest preprint is out! 🚨We discovered that intestinal stem cells actively fight bacterial infections. Learn more about it in our new study by @SachaLEBON in collaboration with @matanhofree biorxiv.org/content/10.110…

Exciting collab with @Honda1Kenya’s lab, out today in @Nature: A set of microbial strains taken from a human faecal donor can decolonize multidrug-resistant Enterobacteriaceae in the gut, including species associated with #IBD. (1/3) nature.com/articles/s4158…

Highly relevant work from @TheXavierLab and @Honda1Kenya lab showing a defined bacterial consortium with the capacity to decolonize multidrug-resistant pathogens. Important implications for treating #IBD with defined FMT protocols Exciting times!