Young-Pearse Lab

We had inspiring discussions, established new collaborations, and the had the opportunity to share our work at the BD² Funded Investigators Meeting in Fort Lauderdale. We are grateful to be a part of a community working to help individuals with bipolar disorder thrive.

Excited to share our latest review!!🧠 “Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin” Check it out here: authors.elsevier.com/sd/article/S09…

We are excited to share our latest publication “POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" in Brain, which we discuss in the recent Brain Podcast episode check it out here: open.spotify.com/episode/1sfNBP…

Happy Holidays from our team!✨

Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!

Thank you to Paul Tesar and Raeka Aiyar for including us in the inaugural Translational Glial Sciences Conference in the Institute for Glial Sciences at Case Western Reserve University School of Medicine. It was a great event!

We're excited to share our new pre-print, where @GizemTerzioglu_ et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia. biorxiv.org/content/10.110…

Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!

We are excited to share our latest publication “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" in Acta Neuropathologica this week! Congratulations Zack Augur!! link.springer.com/epdf/10.1007/s…

New TYP lab publication from co-authors Zach Augur and @FogoGarrett on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.118…

The best of luck to @alexlish47 on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

Huge congrats to Zack Murphy, selected as a 2025 Fujifilm Fellow at @harvardmed !! 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences! Look out for big things ahead from Zack!

Huge shoutout to our brilliant graduate student @GizemTerzioglu_ for delivering a great HMS Neurobiology Pizza Talk! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

🧠 New study in @Brain1878, led by graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13 academic.oup.com/brain/advance-…

Highlights from our lab at the @KeystoneSymp Neurodegeneration meeting! @Heuerwego delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s! @alexlish47 presented a great poster on CLU and intercellular communication in Alzheimer’s!

New TYP lab publication led by PhD student @alexlish47 out today in @CellReports! We present a reproducible neuron-astrocyte-microglia tri-culture model to study intercellular interactions in Alzheimer's disease. Read more here: cell.com/cell-reports/f…

Proud of our amazing postdoc @Heuerwego 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish47