Zha Lab

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come nature.com/articles/s4158…

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7) cell.com/cell/fulltext/…

Thank Nitika! Social DNAing is staying on chromatin for another week with Dr. Aguilera! cancer.columbia.edu/research/progr…

Thank Lydia for a great webinar. Dr. Nitika Taneja from the Netherlands will tell us her exciting big story, hot off the press, at the coming Social DNAing! Sign uphttps://www.cancer.columbia.edu/research/programs/cancer-genomics-and-epigenomics/social-dnaing

Thanks to all of our rising stars for a great section. This week, we are welcoming Dr. Lydia Heasley to unify the karyotype dynamics! Sign up at cancer.columbia.edu/research/progr…

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles and Outlook online now at Genes & Development. Also in this issue, a detailed Review on the molecular and structural mechanisms of non-homologous end joining. Click on the link to learn more: ➡️ genesdev.cshlp.org/content/40/7-8…

@bloodgenes @lvchosen1 @silvirouskin @Armstrong_dfci @CellPressNews @DanaFarberNews @DanaFarber @BroadMPG @broadinstitute @hhmi_science @BostonChildrens @GauravA_UK @guo_chunjie Nice! Congratulations!

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/…

@harriswangnyc @ColumbiaSysBio @ColumbiaBME @Columbia Congratulations! Why isoleucine out of all the 21?

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/sc… 🦠🧬🛠️🖥️💥

Thank Alberto! Future is here. Welcome three rising stars on this week's Social DNAing! Sign up cancer.columbia.edu/research/progr…

Thank you Dr. Luo for an exciting talk. Social DNAing has the honor to welcome Dr. Alberto Ciccia from Columbia this week. Please sign up cancer.columbia.edu/research/progr…

Thank you, Dr. Yi for an exciting talk. This week. Dr. Lou from Mayo Clinic will discuss transcriptional-replication conflicts. Sign up cancer.columbia.edu/research/progr…

Drs. Zhu and Jiang in the lab developed a FISH probe for murine rDNA (Addgene:240559), uncovered high somatic and germline heterogeneities in inbred mouse strains, and proposed a model for single-ended DSB formation at rDNA loci during normal replication. academic.oup.com/nar/article/54…

Thank Dr. Zhang for a great talk. Dr. Yi from UCLA will take us to examine the hidden SCE in cancer genomes. Sign up cancer.columbia.edu/research/progr…

Why mammlian cells need PAR, PARP1/2, but yeast does NOT? While study the impact of PARG inhibition, we found that extra-PAR sequesters nuclear PAR-binding proteins (XRCC1 and its partners and others, into nuclear condensates) preprint is out. biorxiv.org/content/10.648…

Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/lo… Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank @geunil_yi for generating the illustration for all structural models.

Thank Dr. Krejci for a nice story on RAD51. Social DNAing will dive into cancer genetis this week with Dr. Cheng-Zhong Zhang from DFCI. Dr. Sarah Aitken's talk will be rescheduled for a latet time Sign up at cancer.columbia.edu/research/progr…

Thank Dr. Lottersberger for a great talk. Dr. Krejci will discuss RAD51 on Social DNAing this week. Sign up at cancer.columbia.edu/research/progr…

Thank Ylli for a wonderful view on telomere. This week, we have another telomere expert visit - Dr. Lottersberger will discuss the role of DNA-PKcs at telomere. Sign up at cancer.columbia.edu/research/progr…

Thank all our rising stars for an exciting webinar. This week, Dr. Doksani will join Social DNAing to discuss telomere biology! Please tune in! The US is in summertime already! Double-check the local time! cancer.columbia.edu/research/progr…

Thank Titia for a wonder talk. "Oceans rise and empires fall..", but we will also have young stars in science. Tune in for three rising stars on Social DNAing this week! Sign up athttps://www.cancer.columbia.edu/research/programs/cancer-genomics-and-epigenomics/social-dnaing

Thank KJ for visiting us from Korean. Social DNAing is back to New York. Dr. De Lange will tell us something about telomere! sign up cancer.columbia.edu/research/progr…