Peter Ly

My lab is accepting applications for a fully funded postdoctoral fellow position, beginning in 2027. Applicants must clearly articulate specific interests in our lab's research.

James Brugarolas, Daniela Thommen, Pavlos Msaouel, Rashmi Dahiya, and Samvid Kurlekar discussed ""Modeling Kidney Cancer"" in a plenary session at the AACR Special Conference on Innovations in Kidney Cancer Research. #AACRkidney26 @JBrugarolas @PavlosMsaouel @samvid_k

We developed a single-molecule, multi-modal spatial genomics approach to visualize the structure and function of >100,000 individual extrachromosomal DNA (ecDNA) molecules in their native contexts. Preprint link at the end of the thread. (1/11)

We are excited to share our vision for the biomedical and translational implications of somatic mosaicism, published in @CellCellPress. This was a fun team effort with @sfbrunner @imartincorena PJ Campbell and others @CRI_UTSW @QuotientTx @sangerinstitute cell.com/cell/fulltext/…

Become a CRI #postdoc & be part of CRI's #relentlessdiscovery. Apply at cri.utsw.edu/careers #jobs #opentowork #jobopenings #sciencejobs #HiringNow

@EsraAkbay_ Congrats Esra!

The day is finally here. We present a comprehensive characterization of KRAS G12C and G12D driven lung cancers. science.org/doi/10.1126/sc…

Passionate about centromeres? Come join us in New Hampshire in July for the Gordon Research Conference on Centromere Biology! More details here: grc.org/centromere-bio…

Please see AACR kidney cancer special conference final program here: aacr.org/meeting/aacr-s… With 2 keynote speakers (Carl June and Bill Kaelin @kaelin_lab ), 26 invited speakers and 20 selected short talks, this meeting offers comprehensive outlook for kidney cancer research.

🚨NEW PI ALERT🚨 @Henry_de_belly is in the house, and look at that *fresh* new office. Clean slate for his next #relentlessdiscovery in CRI's Tissue Regeneration Program (TRP). Onward! Read more about his new lab 👉 cri.utsw.edu/faculty/henry-…

Check out our paper @CellCellPress where we visualized the interplay between two key DNA replication factors PCNA & RFC and found an unexpected non-catalytic role of RFC in stabilizing PCNA’s interaction with DNA polymerase and enabling efficient synthesis cell.com/cell/fulltext/…

Excited to share our new Nature study! 🧬 We (@UruciSidrit et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful co-directional clashes with DNA replication machinery. This protects cells from R-loops and genome instability. nature.com/articles/s4158…

Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility. Our new article on @biorxivpreprint shows why chromosome cohesion fails in aging eggs & how to improve it. biorxiv.org/content/10.648… (1/10)

We’re back on social media! Wishing you all a Happy New Year!🎉 We hope you enjoyed the magic of the holiday season, but did you know about the MAGIC of uncovering hidden secrets in the genome? Check out our recent paper nature.com/articles/s4158… 🧬+stay tuned for more insights!😊

Excited to share a new Perspective published today in @NatureCellBio, written with Colin Gliech In this piece, we discuss how cells leverage biological “clocks” during mitosis to protect genome integrity—a fascinating layer of regulation in cell division. nature.com/articles/s4155…

2025 marks the 40th anniversary of the initial discovery of CENP-A. To celebrate this milestone, we have edited a special joint issue of Chr. Res. and Chromosoma. Many centromere researchers have contributed review articles. pubmed.ncbi.nlm.nih.gov/41428263/ link.springer.com/article/10.100…

Our study on the mitotic stopwatch is out. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response. nature.com/articles/s4146…

Most honoured and thankful for receiving funding from the @ERC_Research for the #ERCCoG project BrokenChromosomes! We will investigate how scrambled chromosomes in cancer cells arise to drive aggressive disease @embl @emblebi @sangerinstitute @CR_UK

Thrilled to share that my postdoc research is published today in @ScienceMagazine !! We found that DNA repair uses cohesin to build chromatin loops that guide the homology search and boost accurate repair! 1/n science.org/doi/10.1126/sc…

latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet nature.com/articles/s4158… 1/🧵

If you’re interested in aneuploidy, mark your calendar! The FASEB SRC on the Consequences of Aneuploidy will be held Sept 28 - Oct 1, 2026 in Melbourne, Florida. Many speaking slots are reserved for early-career researchers. Please help spread the word! events.faseb.org/event/Aneuploi…