Zhaohan Meng

🚀 New paper: Explainable Physicochemical Determinants of Protein–Ligand Binding via Non-Covalent Interactions We introduce ExplainBind, an interaction-aware framework that explicitly models physically grounded non-covalent interactions (e.g., hydrogen bonding, hydrophobic interactions, and van der Waals forces) for mechanistically explainable protein–ligand binding prediction. Highlights: • ExplainBind: interaction-aware framework for PLB prediction • InteractBind: a large-scale dataset with residue–atom interaction maps • Robust under protein/ligand distribution shift • Binding residue localisation via interaction maps • Experimental validation: ACE inhibitor prioritisation and discovery of L2HGDH inhibitors and activators 📄 Paper: doi.org/10.64898/2026.… 💻 Code: github.com/ZhaohanM/Expla… 🌐 Project page: zhaohanm.github.io/ExplainBind/ 🧪 Demo: huggingface.co/spaces/Zhaohan… #AI4Science #DrugDiscovery #ComputationalBiology #ProteinLigand

Google’s new AI marketing tool Pomelli is on fire lately 🔥 …but here’s the twist: you can build the same kind of platform on @HowOneAI in just 10 minutes ⚡️💡 Try it yourself 👉 apn3vfy-6ff205.howone.app #Google #HowOneAI #NoCode #AIagents #MarketingTech #Pomelli

🚀 Launching HowOne (Private Beta) We’re building a self-evolving agentic app builder — turn ideas into fully working agent-powered apps in minutes (users, DB, tools, payments all built-in). Looking for 300 serious beta testers to break things, push limits & shape the product. Perks: ✨ 3 months Pro free ✨ Founding User badge + lifetime 20% off ✨ Early experimental modules ✨ Roadmap voting rights ✨ Featured in Template Marketplace ✨ 1v1 app-design coaching Apply 👉 howone.ai/?invite=PTTAKF #AI #AgenticAI #AITools #AppBuilder #StartupLaunch #IndieDev #Solopreneur #Automation #Makers #AgentWorkflows

TaoX AI, Glasgow IR and Cambridge LTL at @emnlpmeeting for EMNLP2025! It’s a whirlwind, but we’re handling it like pros 😎 #EMNLP2025 @HowOneAI , @GlasgowCS , @ir_glasgow, @CambridgeLTL

📢 Poster #159 at #EMNLP2025! @Zhaohan_Meng presents FusionDTI: Fine-grained Binding Discovery with Token-level Fusion for Drug–Target Interaction 💊🔬 w/ @mengzaiqiao, @keyuan1 & @iadh — come say hi! 🕧 12:30–13:30 | 📍Hall C

Team @UofGlasgow in Su Zhou 🇨🇳！@ir_glasgow So happy to catch up with friends and meet new ones at #EMNLP2025! What a wonderful community 💬✨ Come chat with us!👋 @mengzaiqiao @JinyuanF @_xizhang @XinhaoYi @Zhaohan_Meng

One person, one sentence, one real AI app. Come chat with us!👏

🎉 #EMNLP2025 Exclusive Giveaway & More! 🎉 💥 500 prizes up for grabs — including AirPods 🎧, GPU credits, and more! Want in? 🚀 How to Enter: 1️⃣ Like and Retweet this post 2️⃣ Visit us at Booth HPC-AI.COM to claim your spot in the lucky draw! 🔑 Limited spots - first come, first served! ⏰ 💡 Extra Perks for Researchers： EMNLP2025 authors get $30 GPU credits CVPR2026 submitters get $20 GPU credits Fuel your next big idea! ⚡ And don’t miss our B200/B300 GPUs starting at just $1.49/hour — exclusive deals available at the booth! #EMNLP2025 #AI #GPU #GPURental #LLM #Giveaway #AuthorIncentives #Research #HPCAI

Powered by EvoAgentX — HowOne brings this self-evolving intelligence into real AI app creation. Build, deploy, and evolve AI apps with a single prompt. One person, one real AI app. #HowOneAI #EvoAgentX #EMNLP #AIapps

Heading to #EMNLP2025 next Tuesday — Suzhou, here we come! 🌟 Excited to share that the AI4BioMed Lab (led by @mengzaiqiao& @jakelever0) has four papers accepted this year!🎉 Come chat with us!👋 @JinyuanF, @_xizhang, @Zhaohan_Meng, @XinhaoYi, @TedSiwei and @mengzaiqiao

Our PLM-interact is out in @NatureComms! We show that jointly encoding protein pairs using protein language models improves protein–protein interaction prediction performance and enables fine-tuning to predict mutation effects in human PPIs. nature.com/articles/s4146…

HowOne AI Alpha Test Begins NOW! You don’t need a team to build your AI startup anymore. With HowOne AI, you can turn your idea into a fully functional AI app—in minutes. Build → Launch → Earn—all in one platform. 🎥 Here’s how it works 👇 #Solopreneur #AIapps #HowOneAI #NoCode #AgenticAI

Evolution of Deep Learning by Hand ✍️ As my tribute to Geoff Hinton's Nobel Prize, I drew this animation to illustrate the key idea behind Hinton's major contributions to deep learning over the years, with artistic liberty. ---- 100% original, made by hand ✍️ Join 40k readers of my newsletter: byhand.ai

fantastic simple visualization of the self attention formula. this was one of the hardest things for me to deeply understand about LLMs. the formula seems easy. you can even memorize it fast. but to really get an intuition of what the Q,K,V represent and interact, that’s hard.

✨ EvoAgentX Community Call — this Sunday! ✨ We’re excited to invite you to our official open-source community meeting 🕒 When: Sunday, 9:30 AM (UK time) 📍 Where: Zoom ID: 862 8273 5663 Passcode: 396325 Over the past months, we’ve been working hard to evolve EvoAgentX from an early prototype into v0.1.0 — our first official release. Now it’s time to share the journey, the lessons learned, and the roadmap ahead. Here’s what we’ll cover: 🔹 Development recap → comparing the very first version with the new v0.1.0 release 🔹 Introduction of EvoPrompt, a simple yet effective prompt evolution algorithm 🔹 How to use multi-agent debate with EvoAgentX to improve reasoning & reliability 🔹 Initializing a memory-enabled agent and diving into our memory module 🔹 Sneak peek at the Wonderful Workflow Corpus — a growing collection of high-quality workflows generated with EvoAgentX 🔹 A look at our future roadmap and development plans This is a great chance to: ✅ Learn how EvoAgentX has evolved and where it’s heading ✅ Get hands-on insights into agents with memory & multi-agent debate ✅ Be part of shaping the open-source ecosystem for self-evolving AI Whether you’re a researcher, developer, or just curious about AI agents, we’d love to see you there and hear your thoughts! Join us on Sunday and help us push the frontier of self-evolving AI agents. #EvoAgentX #AIagents #opensource #multiagent #EvoPrompt

🚀 Excited to share that EvoAgentX, the world’s 1st open-source self-evolving framework for AI Agents, has been accepted at EMNLP 2025 (Demo Track)! It now received ⭐ 1.4k stars on GitHub: github.com/EvoAgentX/EvoA… 🎉 We’ll be presenting it in Suzhou. @EvoAgentX

3 out of 4 papers accepted at @emnlpmeeting #EMNLP2025 🎉 Congrats to @XinhaoYi, Zhaohan Meng, @Auss_Abbood, and all the others coauthors! The remaining one (arxiv.org/abs/2505.18646) wasn’t accepted this time, but it’s still a strong piece of work, and is included in @EvoAgentX!

Self-Evolving AI Agents are about to blow up 🚀🔥 New Survey Alert 🚨 From static LLMs ➡️ lifelong, adaptive agents 🌱🤖 A Comprehensive Survey of Self-Evolving AI Agents... — your roadmap to the future of AI that learns & evolves after deployment! 💡 arxiv.org/pdf/2508.07407

Checkout this video for EvoAgentX Workflow Generation Demo youtu.be/Wu0ZydYDqgg?si… via @YouTube