Hao Zhu Lab

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9L7PXmc1- 1/10

Excited to share our Review in @NatureCellBio with my student @DohunKim96 ! We highlight how nucleotide metabolism is dynamically regulated in physiology and how disruption of this control contributes to human disease. nature.com/articles/s4155…

The life-saving DNA of genetic outliers - I write all about how the search for these individuals who have variants of modifier genes is influencing medicine. Here's a post about my latest story for The Atlantic: roxanne.substack.com/p/the-life-sav…

Here at CRI #relentlessdiscovery = #NeverChaseReality and McBrayer Lab is ready to cheer the #USMNT to the next round. Gooooooooal ⚽️🏆#StarsAndStripes #FIFAWorldCup #FWC26 #WeAre26

@KentsisResearch what about "what matter in life?"

Deliberating a title for a new book about what defines living things to understand biological molecules, development, and disease. Which of the following titles would be most compelling and intriguing for you to pick up this book?

Single-nuclei sequencing showed Yap and Taz promotes distinctive hepatocyte cell fates, but importantly expressed ligands consistent with cell necrosis (Yap) or immune silencing (Taz). #F3" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…

@bloodgenes congrats!

🙏 Deeply honored to receive the 2026 Warren Alpert Prize! This award reflects the work by so many to enable transformative therapies for sickle cell disease and thalassemia, and the power of human genetics to reveal biology and guide new treatments! hms.harvard.edu/news/2026-warr…

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly

🎉 We're proud to announce that our journal has achieved an Impact Factor of 40.1, now the highest in the field. Thank you to our editors, editorial board members, reviewers, authors, and publishing colleagues for making this possible. 👏

#SLAM2026 kicked-off yesterday in Cape Coral, FL! #LiverResearch

👏👏 On a roll with #MotivationMonday & another successful dissertation defense! Congrats to @Zhu_Lab & DeBerardinis Lab grad student @RogerLiang9. Dr. Liang is headed back to medical school to finish up his M.D. Onward! #relentlessdiscovery

Today in @NatureNano, we report an all-RNA lipid nanoparticle (LNP) system for efficient in vivo prime editing (PE). We identify bottlenecks in transient prime editor delivery, develop a workflow for LNP optimization, and use it to rescue a mouse model of phenylketonuria. drive.google.com/file/d/1-rPAaa… 1/12

Very excited to be sharing our new paper, just out in Nature Cell Biology! nature.com/articles/s4155… The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

A central limitation of cellular barcoding analyses has been the loss of native spatial context. With @insitubiology, we developed an adaptable platform for multiclonal lineage analysis that links clonal history to spatially resolved gene expression. cell.com/cell-stem-cell…

@landau_lab @CellCellPress congrats, excited to read this.

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

The timing could not be worse. At #ASCO2026, we saw #daraxonrasib double survival in #PDAC, a reminder that decades of NIH research investment are paying off. Yet federal research funding is being cut. The biggest victims won't be scientists... They'll be future patients

@ODonnellLab_K @ScienceAdvances @UTHealthHouston congrats kate!

Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models. science.org/doi/10.1126/sc…

Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq