O'Donnell Lab

Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models. science.org/doi/10.1126/sc…

What if vaccines could do more than prevent disease - they could help treat cancer? @JinmingGaoLab's groundbreaking research on cancer nanovaccines is featured in @dallasnews. Learn more about this exciting area of discovery: bit.ly/44m8Df6.

Hear from our UTSW postdocs, faculty, and university leaders about our Postdoctoral Scholars Program #postdocs @utswpda @UTSWScience youtu.be/w5u9MHIC77Q?si… via @YouTube

I am thrilled that my postdoc Dr. Shayna Thomas-Jardin was awarded a CRI Ignite Award. This is an amazing transitional award that will fund 2 yrs of postdoc support, and 3 yrs of independent faculty support. Thank you @CancerResearch and CONGRATS Shayna! 🥳

Amid federal funding cuts, CRI is pleased to announce our largest-ever annual grantmaking of 93 awards, totaling $37 million! Explore how CRI's grantmaking spans 48 institutions across 17 states and 5 countries, and funds researchers at every career stage: bit.ly/4as6cek

A prevalent protein in lung cancer, PCDH7, is neutralized when targeted with monoclonal antibodies and promotes immune response in KRAS-driven mouse models, according to a new study. @ODonnellLab_K @UTSWMedCenter @UTSWScience scim.ag/4uPP4r4

Therefore, these mAbs could potentially benefit patients with multiple tumor types in addition to lung cancer./end

While our work has focused on the role of PCDH7 in lung cancer, PCDH7 is highly expressed in several other tumor types including pancreatic cancer, melanoma, & prostate cancers. PCDH7 has also been shown by others to promote brain metastasis.

Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models. science.org/doi/10.1126/sc…

We celebrated Hari’s graduation as he moves on to start a postdoc with @JWHarbourMD. Good luck Hari!

Congratulations Dr. Hari Shankar Sunil!! @UTSWCancerBio @UTSWGradSchool #ProudPI

Congratulations to Steven Hepensteil for passing his qualifying exam!

@shruthy_suresh @IGIBSocial Looking for a great lab and mentor at @IGIBSocial. Look no further. Way to go Shruthy! I am very proud of you!! @UTSWMedCenter @UTSWCancerBio @UTSWMolBiol @utswcancer

Delighted to share my research journey, dreams & about our lab at @IGIBSocial in the first episode of the #MeetThePI series. Hopeful for awesome science with my awesome team. I plan to take a talented & passionate PhD student in December, please apply to IGIB if interested.

Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in @UTSWMedCenter Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology👶🏻, a very exciting frontier in medicine! #neotwitter