Ziyan Lin

Excited to share our study on immune interactions in extramedullary (lung) acute myeloid leukemia (AML) out today at @NatImmunol !! Acute respiratory failure frequently occurs in AML due to leukemia infiltration of the lungs. The question is why and what can we do to suppress it. @VarvaraParask in the lab started this work by mapping AML:stromal and AML:immune cell interactions using scRNA-Seq and Visium/Xenium @10xGenomics spatial tools. nature.com/articles/s4159…

🚨 Excited to share our new Nature Immunology @NatImmunol paper! 🫁 How does acute myeloid #leukemia hijack the #lung and trigger #respiratory failure? We found #AML cells drive #pulmonary remodeling via Galectin-9 & IL-33 signaling. And we identified drug treatments that can reverse it! 💊 Huge thanks to an amazing teamwork co-led with @iannisaifantis1 @VarvaraParask @nyugrossman nature.com/articles/s4159…

@ManelEsteller @VarvaraParask @iannisaifantis1 Thank you so much, Manel! I truly appreciate your kind words. It was a privilege to work with you, Varvara, and the entire team on this project!🎉

@VarvaraParask @ZiyanLin2352 @iannisaifantis1 Varvara, you did such an amazing work! Kudos to @ZiyanLin2352, too!

Key points: • AML reshapes the lung into an inflammatory, damaged niche • Galectin-9 and IL-33 signaling : key players within the AML lung TME • Targeting these pathways reduces lung infiltration and systemic disease burden • Glucocorticoids improve pulmonary function

Grateful for the journey and everyone who made it possible. 💜 Special thanks to Varvara for leading this incredible project from start to finish. Congratulations to all the co-authors and collaborators! !🎉

So excited to announce that our latest paper just got published @MolecularCell. Check out our latest discoveries on the role 3D chromatin hubs in acute T cell leukemia (and thanks to the amazing team who made this work possible) @nyugrossman #NewPaper cell.com/molecular-cell…

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse! Here's my full speech from the Stand Up For Science rally in DC today (Link and text below)