Varvara Paraskevopoulou

Respiratory failure is a leading cause of death in AML. It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally. We looked. 🧵 @NatImmunol 🔗 nature.com/articles/s4159…

Whoa! Ecstatic that our @iannisaifantis1 @nyulangone @IRSantPau Nature Immunology @NatImmunol article about how #leukemia invades the #lung is also in the 99th percentile of all tracked articles of a similar age in all journals according to Altmetric. Recognition to rising stars @VarvaraParask and @ZiyanLin2352 ! nature.com/articles/s4159…

Excited to share our new paper in @ScienceMagazine A subset of lung cancers drives cachexia, not through factors circulating in the blood, but through local lung sensory neurons. science.org/doi/10.1126/sc… big thanks to first authors Michael and @s_kotschi our collaborators

@soobeomlee @NatImmunol Thank you Soobeom!!

@VarvaraParask @NatImmunol Congrats Varvara! Amazing works! I really love this study!!

Respiratory failure is a leading cause of death in AML. It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally. We looked. 🧵 @NatImmunol 🔗 nature.com/articles/s4159…

@abanos @NatImmunol Thanks Aggelos!

@VarvaraParask @NatImmunol Congrats!

@stelioskosmidis @NatImmunol Thanks so much Stelio!

@VarvaraParask @NatImmunol Congratulations Varvara

@MathijsSanders @NatImmunol Thank you Mathijs!!

@VarvaraParask @NatImmunol Congratulations @VarvaraParask, well done!!!

@etrompouki @NatImmunol Thank you Eirini!!!

@VarvaraParask @NatImmunol Congratulations!!!

@efapostolou29 @NatImmunol Thank you so much Effie!!

@VarvaraParask @NatImmunol Congratulations @VarvaraParask and team!!!

@ManelEsteller @ZiyanLin2352 @iannisaifantis1 Thank you so much Manel!

@VarvaraParask @ZiyanLin2352 @iannisaifantis1 Varvara, you did such an amazing work! Kudos to @ZiyanLin2352, too!

Key points: • AML reshapes the lung into an inflammatory, damaged niche • Galectin-9 and IL-33 signaling : key players within the AML lung TME • Targeting these pathways reduces lung infiltration and systemic disease burden • Glucocorticoids improve pulmonary function

Excited to share our study on immune interactions in extramedullary (lung) acute myeloid leukemia (AML) out today at @NatImmunol !! Acute respiratory failure frequently occurs in AML due to leukemia infiltration of the lungs. The question is why and what can we do to suppress it. @VarvaraParask in the lab started this work by mapping AML:stromal and AML:immune cell interactions using scRNA-Seq and Visium/Xenium @10xGenomics spatial tools. nature.com/articles/s4159…

🚨 Excited to share our new Nature Immunology @NatImmunol paper! 🫁 How does acute myeloid #leukemia hijack the #lung and trigger #respiratory failure? We found #AML cells drive #pulmonary remodeling via Galectin-9 & IL-33 signaling. And we identified drug treatments that can reverse it! 💊 Huge thanks to an amazing teamwork co-led with @iannisaifantis1 @VarvaraParask @nyugrossman nature.com/articles/s4159…

Also many thanks to @AkEisfeld @sanamloghavi @ThalesPapaG @artsinyc and everyone else who contributed @NYUGSOM_Path @nyugrossman ! #AifantisLab #Leukemia #TME

This study is the main focus of my postdoctoral work in the Aifantis lab. Huge thanks to all co-authors and collaborators, especially @ZiyanLin2352 for the beautiful computational analyses, my mentor @iannisaifantis1 for his support, and @ManelEsteller & his team!

Thank you @_TanyaBondar_ for highlighting our paper. We are thrilled to see the work out today in Blood Cancer Discovery. For all our friends in the myeloid community, @BCD_AACR has made the full text available for free until Friday! Please download it today brnw.ch/21x2FHK A huge thanks to @AkEisfeld @iannisaifantis1 @audrey_lasry @BettinaNadorp … working with you on this project was a pleasure and a privilege 🙏🏻💜 PS: it is not everyday that you get interviewed by BCD’s Abigail Cleveland in front of not one but 2 #HassanHajjaj pieces in the background … EPIC!!! Stay tuned for the interview!!!

Very excited to share our work on myeloid sarcoma, out today! Don’t miss @iannisaifantis1 presenting it this afternoon at #Myeloid2026

Annual #AifantisLab photo...#2026. Amazing to work with great colleagues...in a great city and institution @nyugrossman ...visit our online sites to learn more on our work in leukemia, epigenetics and tumor microenvironment: aifantislab.com ; med.nyu.edu/faculty/iannis…

@iannisaifantis1 @nyugrossman Congratulations Iannis! Excited for the next chapter!

After almost 13 years I am stepping down from the helm of the Department of Pathology @nyugrossman. It was a privilege and a pleasure to contribute to the creation of one of the most exciting Pathology Departments in the US and to work with fantastic colleagues, pathologists, research scientists, staff and trainees. During this exciting period, the department of Pathology almost tripled its faculty numbers, clinical and research (grant) revenue and invested heavily in a state-of-the-art molecular pathology lab, the growth of molecular microbiology, the expansion and automation of our clinical labs, and the integration of new digital and artificial intelligence tools that are redefining how our pathologists diagnose disease. We are now one of the few departments with ~100% slide digitization and a fully digital sign out. At the same time, the department’s research profile has increased significantly with the recruitment of leaders in the areas of immunology, cancer biology, computational science as well as world-renowned pathologists and physician-scientists. On a personal level, I was blessed to be thrown in deep water early in my life and bet on the talent and brilliance of colleagues who helped me set the foundation for a truly integrated and modern Pathology Department. I remain here to aid the transition of leadership, excited to spend more time in my own research laboratory and soon take up new challenges...@NYUGSOM_Path