Lucie Wolf

Exciting news: our comprehensive review on #Wnt ligand export with focus on Evi/Wntless and Porcupine/Porcn is out now in @dev_journal! Please read and RT @sfb1324 @DKFZ @Boutroslab @Michael_Boutros 1/4 The role of Evi/Wntless in exporting Wnt proteins journals.biologists.com/dev/article-ab…

Proud to share our latest manuscript! 🎉 We quantitatively assessed how WNT5a is transported extracellularly at single-molecule and single-particle resolution. 👉 Read the full paper here: doi.org/10.1111/febs.7… 👇🧵

Do not miss the Gordon Research Seminar (GRS) that precedes the GRC: the GRS is focused on early career scientists, with ample possibility to present your science and to discuss life as a scientist with peers! grc.org/wnt-signaling-…

🚨Dear Wnt people! Registration is open for this year’s Wnt Signaling Gordon Research Seminar (GRS) and Conference (GRC). Join us June 21-27, 2025 in Maine - abstract deadlines for talks are already approaching! grc.org/wnt-signaling-… #Wnt2025 @GordonConf @TalksWnt

🚨Preprint Alert🚨 How does spatial&temporal organization shape Wnt signaling? 🧬🔬 🔍Using #GenomeEngineering, high-content #screening + phosphoproteomics, our study explores how Dvl2 centrosomal phase separation influences #WntSignaling outcomes 📄 doi.org/10.1101/2025.0… 🧵👇

🎉 Excited to share our latest work in @stemcellreports! This marks the final chapter of my postdoc in the @angerslab. cell.com/stem-cell-repo… 🧬✨ We show how individual Frizzled receptors regulate Wnt-β-catenin signaling kinetics in hPSCs, influencing mesoderm commitment🧵1/n

A team led by @UofT researchers has uncovered new targets that could be key to effectively treating #glioblastoma, a lethal type of brain #cancer. Glioblastoma is challenging to treat due to the resistance of its stem cells to therapy. Learn more 👉 uoft.me/Glioblastoma

Very cool to be featured in 'Humans of RHSE'! @RHSE_UofT @DonnellyCentre @StephAngers Read more about my postdoctoral work and beyond here: rhse.temertymedicine.utoronto.ca/news/humans-rh…

A team led by researchers at @UofT and @broadinstitute mapped the impact of #mutations on protein localization in the cell. They found that one in six disease-causing mutations led to #proteins ending up in the wrong location. Learn more 👉 uoft.me/Mislocalization

Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

Congratulations to our 2024 Research Excellence Award Winners! 🥳 Postdoctoral fellows Athanasios Litsios and Lucie Wolf received the #award for their research on the role of proteins in the cell cycle and colon cancer. #UofT Learn more 👉 uoft.me/2024REA

It's a beautiful day at Niagara-on-the-Lake! 🌞 @DonnellyCentre faculty, trainees and staff are at Queen's Landing Hotel for our annual retreat. #DonnellyRetreat2024 #UofT

🔦Preview of Kschonsak et al.: Get your receptors in a knot with new Wnt signaling agonists by @_LuWo and @StephAngers at @UofT dlvr.it/T8YPWP

Incredible work by our collaborators @DonnellyCentre finally out in @Nature! Please read and RT this important contribution to the TPD/TPS field and congrats to @JulinePoirson, @mike_tilapia and the team! 🤗

The origin and evolution of Wnt signalling go.nature.com/3I3R887 #Review by @MichaelaHolzem, @Michael_Boutros & Thomas W. Holstein @TWH00829518 @Boutroslab @UniHeidelberg @COSHeidelberg

It was a great pleasure to work on this exciting topic! Please check out my new Review article on The origin and evolution of Wnt signalling! go.nature.com/3I3R887 #Review by @MichaelaHolzem, @Michael_Boutros & Thomas W. Holstein @TWH00829518 @Boutroslab

exciting news for patients with macular edema!!! Our Frizzled4 Wnt agonist had a positive Ph1/2b trial! eyebiotech.com/eyebio-announc…

Pleased to share our latest preprint identifying a GTPase cascade that modulates regional Wnt signalling in the intestine: biorxiv.org/content/10.110…

New publication from the lab: Aged intestinal stem cells propagate inflammation. Congratulations to Maja Funk @funk_maja - great collaboration with @odom_lab @CancerInflam @haas_lab @angifeldmann @OliverStegle @dkfz @UniHeidelberg #ageing #organoids cell.com/developmental-…

The WntUK network emerged from discussions between UK delegates at recent international Wnt meetings in Japan and Spain. The founding committee is comprised of seven Wnt scientists from all corners of the UK. Read more about the founding committee members below 👇 1/n

Congratulations and best of luck!