Art Assoiants

Knees weak, palms were sweaty

@daniel_mac8 Then lean into this github.com/aassoiants/pro…

This is amazing. Do this.

@Mangan150 Thank you, this prompted (heh) me to write this x.com/aassoiants/sta…

@aassoiants Could be receptor downregulation against hyperinsulinemia. mTOR activation also leads to IR.

My unified theory of aging and disease Claude AI did this, using papers I selected as references. See what you think. The Master Switch: Insulin Resistance Facchini (2001) showed insulin resistance predicts virtually ALL age-related diseases. That's the trunk of the tree. Everything else branches from it. What drives insulin resistance? Kohrt (1993): belly fat, not age. Waist explains >40%, age <2%. Blagosklonny (2006): chronic mTOR activation. Overfeeding keeps mTOR on, cells grow when they should repair. PD's iron paper: iron accumulates with age, activates mTOR, and iron + insulin resistance are co-morbid. What does insulin resistance cause downstream? Khan (2017): high insulin drives high PAI-1, which drives senescent cell accumulation, shorter telomeres, faster aging. The Amish with half the PAI-1 lived 10 years longer. DePalma (2010): high ferritin + inflammation = vascular death. Iron and insulin resistance amplify each other. Madeo (2015): when mTOR is chronically on (from insulin resistance + iron), autophagy is suppressed. Cellular garbage accumulates. Aging accelerates. What reverses it? Lim (2011): type 2 diabetes reversed in ONE WEEK with caloric restriction. The damage isn't permanent. Gibala (2020): 5 minutes of hard exercise produces the same fitness gains as 50 minutes moderate, and improves insulin sensitivity through pathways that bypass insulin entirely (GLUT4). Fisher (2011) + Wolfe (2006): muscle is a metabolic organ that acts as a glucose sink. More muscle = more insulin sensitivity. Resistance training is the most efficient way to build it. What's been wrong all along? Ravnskov (2016) + Siri-Tarino (2010) + Ramsden (2016): the cholesterol/saturated fat hypothesis was wrong. Higher LDL in elderly = lower mortality. Replacing saturated fat with seed oils increased death. The medical establishment spent 50 years focused on the wrong molecule while insulin resistance was the actual killer. PD's iron paper ties the bow: Iron is the hidden variable connecting all of it. It activates mTOR (Blagosklonny), inhibits autophagy (Madeo), worsens insulin resistance (Facchini/Kohrt), increases PAI-1 and senescence (Khan), and accumulates silently with age in every man and postmenopausal woman. The life-extending compounds (curcumin, green tea, rapamycin, exercise) all either chelate iron or inhibit the pathways iron activates. The narrative arc for PD's content: The medical establishment told you aging is inevitable and cholesterol will kill you. They were wrong on both counts. The real driver is insulin resistance, fueled by belly fat and silent iron accumulation, suppressing your body's cleanup systems while accelerating cellular aging. The fix isn't statins or seed oils. It's resistance training, brief intense exercise, fasting, and managing your iron. Every study points to the same conclusion: aging is a lifestyle disease, not a birthday disease.

Prompt me daddy

@callebtc I used it to create the most useful skill in my craft and it saves my ass daily github.com/aassoiants/pro…

If there's one skill you should know about it's how to create new skills.

Most product seeks to solve a data problem

AI accelerates speed to iteration

I'm celebrating 10 YEARS of BTC Sessions and I need YOUR help for a video! ALL I NEED: Record a horizontal video of you saying "This is YOUR... Daily Session" and send it to btcsessions@gmail.com I think this could look awesome. I appreciate all your support this past DECADE!

@ABCundrstandBTC @BTCsessions Solid idea, many thanks!

A Point of Sale integration that : 1) Allows businesses to transfer their skews easily from their existing PoS without having to manually input them. 2) Tracks the Cost Basis of each transaction to make it easier to track when businesses need to convert to cash (maybe a slick calculator to average out the combined cost basis of a batch of transactions) 3) Streamlines accounting (dollar amount, btc amount, time of transaction, cost basis at time of sale) so businesses can easily integrate and have seamless accounting with their other forms of payment. 4)Have a lightning wallet and a self-custody main chain wallet integrated 5) Have a plug in option with Fold or River type applications that allows businesses to connect with their fiat bank accounts THIS STACK ALL IN ONE PLACE WOULD BE A GAME CHANGER FOR ONBOARDING BUSINESS AND MAKING IT SUPER SIMPLE FOR THEM TO SAY YES. The biggest hurdle for businesses is integration with their existing PoS in a way that’s not clunky or too difficult. Square is awesome but is not a good fit for a lot of businesses… we have to find ways to make integration with these other systems easy

So many killer Bitcoin builders out there right now, energy is insane! But what's STILL missing? What’s the one thing that doesn't exist yet but you think would absolutely explode if someone nailed it? If YOU could direct the top devs, what would you build next? Give me your wildest ideas!🔥

@DasBTCMustang @BTCsessions Consider this on your journey github.com/buildinginpubl…

@BTCsessions Hmm, I already started on my project idea, and not sure I want to share publicly until I have it more solidified. Having support though, would be killer, I may reach out in a few weeks. Thanks for all you do to support growth.

@Marcus_Analyst @BTCsessions What do you mean by this?

@BTCsessions Real self-custody tracking. Not just shitcoin price feeds.

11 hacks for arbitraging the dating market 1. The top shortage is real. Dominant men are overpriced. 2. Look for traits that you want your children to have. 3. Good looking boyfriends are a sign of poor time preference. 4. Broad shoulders are just as good as height and the apps don't let you filter for them. 5. There's more alpha in young men. 6. Marry for money not status. 7. Hobbies are really gendered. Don't look for shared interested. Look for a man you can explain things to. 8. Shared politics or 'values' are overrated. You can build a stronger foundation on kindness, mutual respect, and good decision making. 9. Good husbands don't always give you fun dates. Avoid people who are very stylish and take you on lavish dates. 10. Men who aren't on the apps are underpricing themselves. Scoop them up when you find them. 11. Insider trading is good when you can get away with it. You have private information on your friends and, if the fundamentals are good, you should date them. Read more on my Substack. ariababu.co.uk/p/11-ways-to-a…

@JustinPerea @alex_prompter Had the same q

@alex_prompter Is this any different from skills.sh ?

This is AMAZING.. someone just built an App Store for Claude Code. It's called SkillsMP and there are 200,000+ agent skills that teach your AI exactly how to write PPTX files, review PRs, deploy to cloud, analyze data, and more. 100% Opensource. (Link is in the comments)

Taste as moat

👇 github.com/aassoiants/pro…

Stop building the wrong things faster

So good to meet you Merkle!

Feels like it