AbdulAbdul

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AbdulAbdul

AbdulAbdul

@Abdul_Squared

@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A

New York, NY Katılım Mart 2020
816 Takip Edilen604 Takipçiler
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AbdulAbdul
AbdulAbdul@Abdul_Squared·
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s4159…
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Junyue
Junyue@junyue_cao·
New preprint alert🚀 Using TrackerSci, we quantified the birth rate of each cell type across the whole organism, and how these rates are rewired with age. Huge congrats to the incredible Dr. Lu @ziyu__lu from @RockefellerUniv, who just defended today! biorxiv.org/content/10.648…
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Bo Wang
Bo Wang@BoWang87·
Today at #ASCO26, more results about the newest clinical trial of daraxonrasib: In the Phase III RASolute-302 trial, a once-daily RAS(ON) inhibitor nearly doubled median overall survival (13.2 vs 6.7 months) and reduced the risk of death by ~60% versus chemotherapy in previously treated metastatic pancreatic cancer. KRAS was once considered “undruggable.” This is what persistence in science looks like. A landmark moment for targeted therapy and for patients who desperately need better options. #CancerResearch #PancreaticCancer
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Bo Wang@BoWang87

Pancreatic cancer has one of the most suppressive tumor microenvironments in oncology. But two pancreatic cancer results dropped today. Both matter. 1. BioNTech mRNA neoantigen vaccine: nearly all responders still alive at 6 years. 98% of induced T cells were de novo — the immune system learned to see a cancer it had always been blind to. 2. Daraxonrasib: 47% ORR, 92% disease control as first-line monotherapy. KRAS G12D, undruggable for 40 years, finally has a drug. Different mechanisms. Same disease. Both working. <13% of patients survive 5 years. That number is about to change. great day for science! 🔥

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Eric Topol
Eric Topol@EricTopol·
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines nejm.org/doi/full/10.10…
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thmonk
thmonk@thmonk_pf·
lymphocyteが脳老化に於る炎症と脳室恒常性を制御 IRISeqは光学撮像不要のビーズ間配列決定で脳組織を空間的にprofiling 老齢mouse脳で脳室IFN炎症をlymphocyteが駆動しlymphocyte欠損が上衣細胞を保護する新機序を解明 OA #aging #immunology #papers nature.com/articles/s4159…
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AbdulAbdul
AbdulAbdul@Abdul_Squared·
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s4159…
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Zihan Xu
Zihan Xu@xu_zxu·
Congrats to @Abdul_Squared, @junyue_cao, @Wei_Zhou_1989, and the whole team!! So honored and excited to witness a brand-new chapter of spatial transcriptomics being built from scratch 🎉✨ Time for all the hard work to pay off!!
AbdulAbdul@Abdul_Squared

Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s4159…

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Junyue
Junyue@junyue_cao·
Our scalable, cost-effective, and optics-free spatial genomic technique, IRISeq, is out in Nature Neuroscience today! Congrats to incredible @Abdul_Squared and @Weirong_Jiang from our lab at @RockefellerUniv
AbdulAbdul@Abdul_Squared

Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s4159…

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AbdulAbdul
AbdulAbdul@Abdul_Squared·
alongside my partner in crime @Weirong_Jiang , and the rest of our awesome collaborators @xu_zxu and @Tommyz626 , and the rest of the team. Very grateful to @NatureNeuro, the reviewers, and Dr. @RongFan8 for helping us improve the work through their deeply insightful comments.
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AbdulAbdul
AbdulAbdul@Abdul_Squared·
explore how lymphocytes depletion modulates brainwide interferon-associated signatures in aging. This work would not be possible without my amazing mentors @junyue_cao and @Wei_Zhou_1989 , whose unwavering support made this work possible. Also incredibly grateful to have worked
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Santosh Vardhana
Santosh Vardhana@SantoshVardhana·
I don’t post much anymore but thought I would take a moment to share my feelings on an issue that has been papered over by the negative impact that external forces have had on science and scientists: the toxicity of our own interactions within the scientific community. (1/10)
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Keşfet

@ziyu__lu @RockefellerUniv @NEJM @ASCO @RevMedicines @KafuiDzirasa @DukeU @hhmi_science