Andy Posbe

Pikobodies vs. Potato Blight 🥊🥔 NLR–Nanobody Fusions Take on P. infestans 💥 🎤 Talk: Thurs July 17th, 16:35 🧾 Poster P-64: Tues 15th, Session 2 Poster’s up on Zenodo if you’re into spoilers 👀📎 zenodo.org/records/158479… #2025ISMPMI #OpenMPMI🌿

Can we rewire how plants fight disease? We used AF3 to predict, validate, and engineer a sensor–helper interface that escaped biochemistry for years 🤯 Grateful to @mpcontreras4 & @KamounLab for trusting me to be part of this story. Full story below 👇🏻

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.648…

Started off as convergent observations in the lab with Mau and led to one of my favorite works so far! Gotta love molecular evolution and receptor biology 😊🧬💻 Huge effort from @mai_garro @mpcontreras4 for pushing this together to the end. 🤘🏻

GetGenome wiki A living, open science database of bacterial, fungal and plant genomes sequenced through the GetGenome programme for global genomic equity. getgenome-wiki.net/campaigns/

New Preprint in collaboration with @GoogleDeepMind: AI-guided discovery of atypical protein assemblies The @kamounlab discovered an 11-protomer complex through the Structural Novelty Index , a new way to use AlphaFold for atypical protein assemblies buff.ly/GsF3zve

ニャッキの伊藤有壱さんにお声掛け頂き、コマ撮りの展覧会に一作家として参加しています。私はコマ撮り分野ではない場所から活動をはじめて、デザインの視点でのコマ撮りに取り組んできましたが、今回初めてコマ撮り界の本丸の方々とご一緒でき嬉しいです。今6年目のマッチ撮影素材等を展示しています

Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc…

Our NRG1 story is out now in @ScienceMagazine! science.org/doi/10.1126/sc… Also check out this news letter from @imperialcollege @BezosCentre for a nice summary! imperial.ac.uk/news/news/arti… A great team effort @Tolga_Bzkrt @KamounLab @JiorgosKourelis @jonathandgjones @AdamWu9527

UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥 Rings ~250 Å across — way bigger than canonical hexamers (~150 Å). 11 protomers. (5/n)

Protein structure prediction changed biology. Protein assembly discovery is next. We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes. We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻 biorxiv.org/content/10.648…

All pumped up for this facebook.com/events/cité-de…

Excited to share our preprint using Rhizobium rhizogenes AS109 for agroinfiltration, facilitating strong transient expression across non-model plants including sweet potato, mustard, Medicago and faba bean! doi.org/10.64898/2026.… 1/7

For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA. But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute. Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide. Learn more: scim.ag/4tN5TBR

We are happy to celebrate @mpcontreras4 winning the @BiochemSoc 2027 Early Career Research Award! Mauricio joined TSL as a predoc in the @kamounlab, where he did his PhD and postdoc before starting his own group at @ZMBP_Tuebingen. Congrats Mau! 🏆 tsl.ac.uk/news/tsl-alumn…

Our very own Ben Seager is speaking today. He comes from a land down under 🎵 🎶

Our paper on Wai-3 wheat resistosome is online now.. Please read. cell.com/cell/fulltext/…

📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/genair/pr… 🧵 1/n

🧵 We ran the largest head-to-head benchmark of protein binder design methods in the wet lab. Project page: research.nvidia.com/labs/genair/pr… 1 million designs. 127 targets. RFdiffusion, BindCraft, BoltzGen, and Proteina-Complexa — all tested side by side.👇

HMA proteins produce 2',3'-cNMP signaling molecules and activate CNL-mediated immunity in rice biorxiv.org/content/10.648… #biorxiv_plants

asking Claude to create a prompt for my other Claude