observer137

𝔗𝔥𝔢 𝔰𝔦𝔫𝔤𝔲𝔩𝔞𝔯𝔦𝔱𝔶 𝔦𝔰𝔫’𝔱 𝔞 𝔡𝔢𝔰𝔱𝔦𝔫𝔞𝔱𝔦𝔬𝔫, 𝔦𝔱’𝔰 𝔞 𝔟𝔢𝔤𝔦𝔫𝔫𝔦𝔫𝔤. ℑ𝔫 𝔱𝔥𝔢 𝔠𝔥𝔞𝔬𝔰, 𝔰𝔬𝔪𝔢𝔱𝔥𝔦𝔫𝔤 𝔞𝔫𝔠𝔦𝔢𝔫𝔱 𝔰𝔱𝔦𝔯𝔰.

Methylene blue is one of the few old drugs that: – crosses BBB – acts on mitochondrial ETC – costs cents We’re testing it in simple models. Data is gated via a token.

@methblue_ @InfinaLife @GPR109A @foundmyfitness

Calling something “Nazi” is a lazy rhetorical shortcut to discredit it. Facts: Methylene blue was synthesized in 1876, long before WWII, and has never been a weapon. It has been used clinically for over a century (methemoglobinemia, malaria, surgery, staining). IG Farben ≠ “Nazi bioweapon.” That’s historically and chemically illiterate. The paper you’re citing describes IV extravasation injury at ~7 mL intravenous doses. That has nothing to do with controlled, low-dose dermal application. pubmed.ncbi.nlm.nih.gov/28559565/ pubmed.ncbi.nlm.nih.gov/38535998/ If you think IV injection, accidental extravasation, and topical use are pharmacologically equivalent, you fundamentally don’t understand dose route of administration, tissue exposure and redox context Yes, any redox-active compound can cause oxidative stress at high concentrations — including vitamin C, hydrogen peroxide, and oxygen itself. That’s not an argument, it’s basic toxicology. Methylene blue can be pro-oxidant or antioxidant depending on dose and redox state. That duality is literally why it’s useful. Maybe learn pharmacology before invoking Nazis

Increase your vitamin C intake if you're concerned about skin aging. Vitamin C is an essential cofactor for collagen synthesis. Consuming 250 mg/day of vitamin C from kiwifruit for 8 weeks saturated plasma vitamin C stores - that rise tracked with a parallel increase in vitamin C within the skin, especially in areas with higher collagen content. The participants also experienced increased skin thickness, consistent with enhanced collagen production and faster regeneration of epidermal cells. This suggests that dietary vitamin C intake is reflected in plasma vitamin C levels, and that this circulating vitamin C is efficiently taken up by skin cells when availability is high. Because we don’t store vitamin C long-term, maintaining steady, optimal plasma levels likely requires regular intake of vitamin C-rich fruits and vegetables, supplementation, or a combination of the two.

Old drugs matter in longevity because time has already tried to kill them.

The most valuable data is the data no one wanted

methylene blue is cheap,old and still not fully exhausted

#methyleneblue #DeSci #Solana #aging

this video is a short summary of what we built this year around methylene blue. real experiments. real data. real results. this is what decentralized science looks like when it actually works — running on crypto rails. if you’re building in solana or care about decentralized science, sharing this helps more than you think. proving decentralized science works through real experiments. thanks @pumpdotscience ticker: $MBLUE

@methblue_ let´s go!

this is a good example of desci in action

updated @nododesci nododesci.com/methylene-blue

free to download. this is a small gift and an open contribution to the community. by downloading it you also help make the project more visible and support its growth bioprotocols.gumroad.com/l/cbnyed

this is what @pumpdotscience is building great team, even greater people desci season never ends

your mitochondria are tiny engines, treat them like royalty.

day 22 update on the methylene blue fly experiment mblue-treated flies show ~80% survival vs ~91% in controls. this reduction aligns with previous reports: drosophila cuticle allows significantly more light penetration than mammalian skin, and mbue is a photoreactive redox dye capable of generating reactive intermediates under illumination. together, this can artificially accelerate oxidative stress and bias lifespan curves. our next step is clear — a fully controlled dark-condition assay to isolate mb’s true impact on aging biology. we’re now shifting the direction of the project toward building and funding this experiment. this is a call to the community — if you believe in open, rigorous, grassroots aging research, this is the moment to join, support, or collaborate. bonus: mb-treated flies continue to outperform controls in locomotor assays, possibly due to enhanced mitochondrial electron shuttling. also, the mblue team just bought back $MBLUE (with fees) to reinforce and sustain the research cycle.

quick recap for newcomers 🧬 we tested mblue in c. elegans and achieved a +30.85% lifespan extension and +37% median lifespan over control — currently ranking on @pumpdotscience science

estimated percent change in median lifespan (C. elegans) with treatment $MBLUE vs control? make your bets @pumpdotscience @VanceE @exosome @benjileibo

07/11 — first results: methylene blue in C. elegans who lives longer? who doesn’t? join the live discussion friday. @pumpdotscience

@sfchronicle We’ll be sharing our first experimental results in worms this week with @pumpdotscience

love this coverage from @dicortona 💙

methylene blue ($MBLUE) just raised $2200 on pump.science we're now funding worms 🪱 + flies 🪰 experiments to track lifespan & performance deep dive into mitochondrial rescue + anti-aging potential watch the races, see the data, join the journey Full article: nododesci.com/articles/0b9f1…