Alessandro Sammarco

👏Congratulations to our #EANO2024 award winners for Best Poster Presentation: Sophie Bockel (Clinical research), Alicia Buck (Basic research), Alessandro Sammarco (Translational research), Cressida Lorimer (Supportive care & quality of life research)! #NeuroOncology #btsm

Off to Glasgow for #EANO2024. Excited to present some of our work on lipid metabolism in #braintumors. Also proud of @ale__samma , who was selected to present his work on breast cancer brain metastasis during the Poster Pitches Session @EANOassociation @MGH_RI @MGHNeurology

@BadRlab @katharinaeyme These findings suggest that SCD inhibition could be an effective strategy to intrinsically reduce tumor growth and reprogram anti-tumor immunity in the brain microenvironment to treat BCBM.

Excited to share our latest work where we tested the effect of a brain-penetrant clinical-stage inhibitor of fatty acid desaturation on cancer and immune cells in breast cancer brain metastasis mouse models. @BadRlab @katharinaeyme biorxiv.org/content/10.110…

@BadRlab @katharinaeyme Pharmacological inhibition of SCD decreased engagement of immunosuppressive pathways, including the PD-1:PD-L1/PD-L2 and PVR/TIGIT axes in the tumor microenvironment.

@BadRlab @katharinaeyme Inhibition of SCD enhanced antigen presentation by dendritic cells, was associated with a higher interferon signaling, increased the infiltration of cytotoxic T cells, and decreased the proportion of exhausted T cells and regulatory T cells in the tumor microenvironment.

@BadRlab @katharinaeyme Combined targeting of SCD and PARP prolonged survival of mice with breast cancer brain metastases.

@BadRlab @katharinaeyme Pharmacological inhibition of SCD markedly reshaped the lipidome of breast cancer cells and resulted in endoplasmic reticulum stress, DNA damage, loss of DNA damage repair, and cytotoxicity.

I've decided to join the TEXAS MS 150, a fundraising 150-mile bike ride that changes the world for people affected by Multiple Sclerosis. If you'd like to donate, in the first comment you'll find a link to my fundraising webpage. Thank you for your support!

#GBM are lethal, molecularly heterogeneous tumors – it was unknown whether this molecular diversity led to distinct phenotypes and metabolic lipidomic vulnerabilities. New, open access @Cancer_Cell paper: sciencedirect.com/science/articl…

It is so exciting to see our work highlighted in @NatRevDrugDisc Drugging a metabolic vulnerability in glioblastoma nature.com/articles/d4157…

A compound that targets de novo lipid synthesis in #GliomaStemCells shrinks #glioblastoma tumors in mice, potentiates DNA-damaging agents, and can penetrate the blood-brain barrier.  Read more: scim.ag/1eG @katharinaeyme @BadRlab @ale_samma

We are so thrilled to see our work published in @ScienceTM on a new therapeutic strategy that inhibits de novo lipid synthesis to treat glioblastoma. Thanks to @BadRlab, @katharinaeyme and co-authors. Also, many thanks to @AICF_nyc for their support.

Here is our latest work on #lipidmetabolism in #glioblastoma. Fascinating results on what drives sensitivity and resistance to fatty acid inhibitors in glioblastoma. @BadRlab @katharinaeyme biorxiv.org/content/10.110…

Attending SNO? check out work from our group led by the outstanding @katharinaeyme EXTH-23 - Preclinical efficacy of a targeted, brain penetrant inhibitor of fatty acid desaturation in glioblastoma cdmcd.co/q9Wgqg #sno2021 #BTSM

We are looking for a research techI/II to join our group @MGHNeurology @harvardmed @MGH_RI. If you are interested in brain tumor research feel free to reach out. #MedTwitter #AcademicTwitter More info 👇

👑 #1 public university 🐻 5 years in a row! 💙 🎉 💛 #1UCLA ucla.in/3txsPqP

We have an open post-doc position for a newly funded project in our lab. If you are interested in studying stress signaling and lipid metabolism in brain tumors let's talk. More details👇👇 partners.taleo.net/careersection/… #MedTwitter #AcademicTwitter @MGHNeurology @harvardmed @MGH_RI

UPDATE: If you are fully vaccinated against #COVID19, you can resume activities without wearing a mask or staying 6 feet apart, except where required by federal, state, local, tribal or territorial laws, incl. local business and workplace guidance. More: bit.ly/3btJaFU