Andrew Bellinger

I’ve always believed the No.1 application of AI should be to improve human health. That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease! We are turbocharging that goal with $2.1B in new funding.

As @EliLillyandCo celebrates its 150th birthday this week, a fun throwback: the LLY Web Standards doc from 2000 "The Internet is a key delivery point of the Lilly brand" We don't talk a lot about brand and culture in this industry, but I personally love the old LLY brand line ("Answers That Matter"): data-driven, evidence-seeking in pursuit of impact. This phrase was on every company slide, every presentation, every corporate artifact ... not hard to see how it may have contributed to a culture of scientific and execution excellence as the company grew uploads.teachablecdn.com/attachments/2t…

@brithume How about on the terms of, “are we better off or worse off than before Trump pulled out of the joint agreement with Iran in 2016?” The answer is clear.

The US mission in Iran is being judged by a standard in which only complete capitulation is victory for the US but mere survival is victory for Iran. This is nonsense as the post below makes clear.

Axelrod: There are a lot of people who would like you to run for president in 2028. And there are others who would like you to run for the senate. AOC: In this op-ed that Bezos paid for in The Washington Post, there was a veiled threat—it was the elite saying if you want this job, you just stepped out of line. What’s funny about that is they assume my ambition is positional. They assume my ambition is a title or a seat. My ambition is way bigger than that. My ambition is to change this country. Presidents come and go, elected officials come and go, single payer healthcare is forever.

@vintweeta That is my sense as well!

Also true: doctors are total power users of "Claude as concierge doctor" Recursive elegance! Super fun to imagine the implications of both facts simultaneously

Sued by Patel and after news broke that the FBI is investigating her piece, she just drops this. Love it

Search is full of ads and wrong answers. Every other email is an ad. Prime Video charges you and shows ads. Paramount? Ads. Peacock? YouTube? Hulu? Ads followed by more ads. Netflix full of ads. Meta and X, every other thing is an ad. Pinterest is nothing but ads. AI is in everything. AI finishes sentences incorrectly and won’t stop. AI reads your email and search history to target you with more ads. Every time you open an app or visit a site there’s an update making it worse. In a hurry? First, click here to agree to terms you don’t have time to read and must accept. You need an account to do that. Change your temporary password. Enter your 2FA code. Check your email and enter that code. Now use a passkey. Your password is too simple to remember. Change it. No, not like that. Now log on. Enter your 2FA code. Check your email for a code… Welcome back! We’ve updated our terms of service and privacy policy (you have none). Subscribe to the site. Subscribe to Netflix. Subscribe to toilet paper. Subscribe to these groceries. Pay a membership fee for the right to subscribe then tip your driver who delivers the subscriptions your membership lets you subscribe to. Time to work? We’ve got to update your laptop and will slow down everything you do until you agree to update. But first, click here to agree. Update installed — your laptop’s broken now. It doesn’t matter, since your boss just replaced you with AI. Go to your phone to complain on social media. Wait, your phone needs an update so we can add more AI. Click here. Oh sorry, your phone can’t handle this update. Now it’s useless. Go get the newest phone. Here’s a text from a friend, an email, a voice mail they left three days ago but you didn’t see until now because of sync problems with the cloud. It’s their GoFundMe. Their MLM. Their Patreon. Never mind, you didn’t respond to their text within 9 minutes and now you’re no longer friends. They blocked you. Make new friends. Download this app to find people in your area. In your neighborhood. On your street. Two doors down from you. Do you know this person yet, we think you’d get along. You need an account to use this app. That username is taken. Enter a password. Not that one, you used it on another site. You need to be connected to WiFi to download the app. Allow the app to connect to other devices on your network. Allow the app to access your contacts, know your precise location, store your credit card details. Oops, sorry, we got hacked now all that info is available on the web. There’s a class action suit. You can join. It’ll take a decade to get your $3.73 share of the ten billion settlement. We’ll send it via PayPal or deposit it to your bank, just tell us those details. Oh no, another hack. That info is circulating now, too. Here’s a spam call, a spam email, a spam text. Why are you angry? Why are you talking about getting rid of your phone? Why don’t you like AI, it lets us make all of this easier? Do you know how ridiculous that sounds? This is progress. You’ll be left behind. Do you want to be left behind? Do you???

A relevant Texas image today: President George W. Bush and Rep. Sheila Jackson Lee, D-Houston at the signing of the 2006 Voting Rights Act Reauthorization The 25-year reauth extended key VRA provisions including Section 5 (preclearance), and passed unanimously in the Senate

LBJ signs Voting Rights Act, US Capitol Rotunda, 1965.

Oil painting I did of Dr. Eugene Braunwald, my friend & mentor since 1986 flickr.com/photos/cmichae…

The American Heart Association mourns the passing of the legendary cardiologist Eugene Braunwald, M.D., widely recognized as one of the most influential figures in the history of cardiovascular medicine. Over seven decades, his work reshaped the understanding and treatment of heart disease, leading many to call him the father of modern cardiology. Braunwald was a lifelong contributor to the American Heart Association, helping advance its research and scientific mission, and was honored with some of the Association’s highest honors for his lasting influence on cardiovascular care and research. His influence extended well beyond his own discoveries, as generations of Association‑supported investigators, clinicians and academic leaders were trained by Braunwald or guided by the clinical trial standards and mentorship models he helped establish. newsroom.heart.org/news/american-…

With deep sorrow, I received the news of Dr. Eugene Braunwald’s passing, one of the greatest figures in world cardiology. His scientific legacy, clinical vision, and immeasurable contribution to generations of cardiologists will continue to live on in our daily practice and in the history of medicine. My heartfelt condolences to his family, friends, students, and to the entire cardiology community. May he rest in peace.

In the AI era, the traditional biopharma industry is the underdog. Big tech and AI labs are building wet labs. China has overtaken Europe in molecules produced. But the tools available to the industry discuss science, not do it. The hard problem in AI for science is at the interface between the physical and digital worlds. We built an AI Scientist at that seam. It wires together the digital and physical worlds of R&D. Predictive models, data infrastructure, wet lab execution feed into a single loop that reasons, acts, and improves with every experiment. Our ambition: get molecules to the clinic twice as fast. Last fall I wrote about why biotech needs to be rebuilt for the AI era. Today I'm sharing the next chapter: what the AI Scientist is, a blueprint for how it works, and why even Richard Feynman couldn't hack it in a wet lab.

What do RevMed and Kelonia have in common? Michael Fischbach. Co-founder of both businesses. RevMed is up 50% on potentially practice-changing data for pancreatic cancer patients. Kelonia was acquired for up to $7B by Lilly for incredibly compelling Phase 1 data in multiple myeloma. When we announced him joining us as an advisor at Amplify, I wrote, "Few scientists make as many original—and distinct—contributions in their career as Michael." This is what I'm talking about. Two completely distinct modalities. Huge impact. Giving him a shoutout because he'll be quietly cooking on his next big project, not making a victory lap looking for credit. Wonderful human and scientist.

@JonathanTurley Would be nice if you had the integrity to devote any effort to holding anyone on “your side” accountable.

In one week, Eric Swalwell was forced to drop out of the California race, put under criminal investigation in New York, and is the subject of a bipartisan expulsion effort. He was even kicked out of the home of a billionaire who was letting him crash. However, that is not all...

PM Carney: "Many of our former strengths, which rested on our close ties with the United States, have become our weaknesses now ... And while we have overcome the initial shock of the betrayal, we must never forget the lessons it has taught us. We must take care of ourselves."

You know what would be amazing if Vance and his team can negotiate an agreement where Iran doesn't enrich above 3.67% (far below weapons grade); gets rid of 98% of its stockpile of enriched uranium; has weekly inspections by the IAEA; keeps the straits open without charging anyone; and commits to all of this for at least ten years. Oh, yeah, that was the Obama Iran deal.

On the helicopter leaving the ship right now. This planet is impossibly beautiful from every altitude I’ve seen it…surface to 250,000 miles

🇩🇰 The Danish King (yes we have a real King with a gold crown and not a wannabe-king with a gilded ballroom) will soon present Denmark’s 10 point plan for the future peaceful relations between Denmark, Greenland, and the US: 1. The US will guarantee a stop for all agressions against Denmark/Greenland 2. The US will pay reparation to all Danes for insults and threats 3. Trump/Vance will abstain from all future insults and threats 4. Trump will recognize Danish sovereignty over Greenland 5. The US will pay $2 million for every US vessel passing through the Davis Strait and the Denmark Strait 6. Only the national flags of Denmark and Greenland can fly over US bases in Greenland 7. Trump will guarantee that there will never be a McDonald or a Trump Tower in Greenland 8. The US will substitute Columbus Day for Viking Day 9. The US will return the Virgin Islands to Denmark because of moral mis-management (Epstein’s Little Saint James) 10. Trump and Vance will be allowed to brag about this plan as a victory for America 🇩🇰🇬🇱🇩🇰🇬🇱🇩🇰🇬🇱🇩🇰🇬🇱🇩🇰🇬🇱

An American president threatening the death of an ancient civilization is in some ways the end of the 250-year moral experiment of a constitutional republic that the framers saw as a model for all mankind.