Amit Dutt

1/n Thanks to NAR Cancer @NAR_Cancer_EIC, for publishing our recent finding along with Dr. Sudhir Nair @ACTREC_TMC doi.org/10.1093/narcan…. We have a long-standing interest in studying pathogens associated with human cancer.@India_Alliance @DBTIndia @the_hindu @RPrasad12

Ph.D applications at @UnivofDelhi is open. Last date for applying is Mar 24th. You may register and apply here: phd-ph2-2025.uod.ac.in/index.php/regi…

@bushraiitk @ANRFIndia Congratulations, Bushra! Well deserved!

Thanks to the @ANRFIndia for recognizing our research in the fight against cancer. This recognition is a testament to the unwavering dedication, collaboration, and hard work of our entire team. Grateful to all current and former members of Molecular Oncology Lab #CancerResearch

@Chauhanlab_ILS @embojournal Very elegant study, Santosh! Very well described! Many congratulations!

FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n

Pleased to share an imp study on AI resistance in HR+ breast cancer--led by Suhail in my lab @UnivofDelhi & @CRI_ACTREC! We show insulin sig' mutations, ESR1 upreg', and a novel ESR1-PPP3CA fusion: new therapies to overcome resistance. Thanks @DBTIndia sciencedirect.com/science/articl…

@sanjeevtmc @DeepPant94 @iiserbhopal @ANRFIndia @ERPLab_IISERB Congratulations, Sanjeev!

Excited to share our new eLife paper! Deepak Pant @DeepPant94 found that the YEATS2-GCDH axis regulates histone crotonylation, which drives the expression of the EMT-promoting gene SPARC in head and neck cancer. @iiserbhopal @ANRFIndia @ERPLab_IISERB elifesciences.org/articles/103321

Pleased to share our twin study (back-2-back), by Vaishakhi Trivedi from K Prabhash gp, @VanitaNoronha , my lab @CRI_ACTREC/@ACTREC_TMC & Dept of Genetics @UnivofDelhi on papillary and anaplastic thyroid ca. sciencechronicle.in/2025/07/19/two… ascopubs.org/doi/10.1200/GO… ascopubs.org/doi/10.1200/GO…

Can microbe DNA in blood reveal lung cancer? biopatrika.com/academia/resea… Thank you @biopatrika for highlighting the work of Vichitra Behel and Supriya Hait from Kumar Prabhash's lab @TataMemorial and my lab at @UnivofDelhi / @CRI_ACTREC in collab with @1cellAi and @4baseCare

11 of n: We emphasize the need for stringent bioinformatics approaches to ensure accurate cancer microbiome profiling from liquid biopsy. Thanks to ICMR (@ICMRDELHI), DHR (@DeptHealthRes) for the funding. And,@DAEIndia for the transformative agreement with @SpringerNature for OA.

10 of n: Offnote, efforts from research groups have shown plasma microbiome signatures as a promising approach in detecting colorectal, pancreatic (metagenome-based) & lung cancer (WGS-based). Our study, along with others, however, suggests several more nuances to be overcome.

Pleased to share our study led by Dr. K Prabhash, @VanitaNoronha from @TataMemorial, and me from @UnivofDelhi in collab with @1cellAi & @4baseCare where we found… nothing! Published in NPJ System Biology & Applicant (@Nature_NPJ). nature.com/articles/s4154…

9 of n: It highlights key limitations in our study: low microbial DNA abundance, risk of overestimation by standard tools, need for better microbial enrichment, and cleaner databases. So we now know what not to do — and that’s a crucial lead!

8 of n: We thus concluded that under our experimental set up neither CGP nor WES — in their current form — can reliably detect a microbial DNA signature in plasma to identify lung cancer. But this study is still relevant.