Andy Fraser retweetledi
シーケンスによる代謝物の定量法(smol-seq)
標的代謝物が結合したときに構造が変化することでバーコードDNAを遊離するアプタマーをデザイン。バーコードをシーケンスすることで代謝物量を測定。高い特異性と多重検出能力を持ち、診断や治療応用にも期待ー面白いアイデアです
nature.com/articles/s4158…
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Andy Fraser
41.8K posts
Andy Fraser
@andy_utoronto
you can't put a fire out with gasoline. apparently i need to say that my opinions are my opinions. so there you go.
Katılım Kasım 2014
1.2K Takip Edilen1.8K Takipçiler
Andy Fraser retweetledi
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Finally - we are now hiring multiple positions to bring this tech to reality. If you have aptamer experience or are a compbio person excited to learn how to predict aptamer-target interactions, please DM me!
English
Delighted to share our paper describing a way to read levels of 100s of metabolites or drugs in parallel using DNA sequencing. This method which we call ‘smol-seq’ (Small MOLecule sequencing) harnesses the power of DNA sequencing for metabolite detection
nature.com/articles/s4158…
English
Really cool work from @andy_utoronto! Converting metabolite abundance into barcode abundance with aptamers. Smol-seq is the best -seq!
Nature Biotechnology@NatureBiotech
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing go.nature.com/42BbXTQ
English
@drugmonkeyblog Glad to see an honest direct post instead of toxic positivity “don’t give up!” crap. I can’t think of anything that isn’t fucked by this and the more I try the worse it gets. This empowers every horrible nasty violent corrupt bigoted ignorant person and regime.
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Andy Fraser retweetledi
Andy Fraser retweetledi
Do you have one of those fancy interactive maps for
Where to find a family doctor
Open ER
Deeply affordable housing unit
Properly funded school
A moment in time where your government wasn’t wasting money on Beer
#ONpoli
Doug Ford@fordnation
#DYK our interactive map that shows the thousands of new places you can buy beer, wine, cider and coolers also shows where you can return your empty cans and bottles? Check it out to find the closest Ontario-made producer near you, as well as the most convenient place to bring back your empties. ontario.ca/page/where-buy…
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Andy Fraser retweetledi
Andy Fraser retweetledi
Paying $13M for the repairs necessary to keep the Ontario Science Centre open through to 2034 would have been the equivalent of reducing the $200 pre-election handout cheques to $199.19.
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Andy Fraser retweetledi
Andy Fraser retweetledi
This is aggressively stupid. It will accomplish nothing but to get people killed.
Jeff Gray@jeffreybgray
BREAKING: Ontario has just proposed regulations that would rip out bike lanes in Toronto on Bloor, University and Yonge: ero.ontario.ca/notice/019-926…
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Andy Fraser retweetledi
Canada’s Geoffrey Hinton, #AI pioneer, and @UofT computer science professor, co-winner of #NobelPrize in Physics with American John Hopfield, by @IvanSemeniuk via @globeandmail @NobelPrize theglobeandmail.com/world/article-…
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@picardonhealth @alexbozikovic @globeandmail “Will nobody think of the parking revenues??!”(aaarghh)
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Toronto needs to get over its fear of car-free streets. Major cities around the world, from Paris to Montreal, are creating “pedestrian🚶♀️zones” and cycling🚴♂️ infrastructure, and they are better for it, by @alexbozikovic theglobeandmail.com/arts/art-and-a… via @globeandmail
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