Anika Singanayagam

Listen to a Lancet podcast where we discuss our @LancetMicrobe #humanchallenge paper here: buzzsprout.com/1794195/130241…

US - California: CDPH statement - 3rd #H5N1 confirmed human case confirmed by the CDC. + 2 more possible cases identified with CDC tests pending. All are animal contact, mild symptoms. #post998329" target="_blank" rel="nofollow noopener">flutrackers.com/forum/forum/un… h/t Commonground

@jbloom_lab What is the effect of S323 on HA stability? Looks suspiciously close to the fusion peptide and several other mutations well described to affect stability.

Here are the locations of the mutations on the HA structure. Two are on the head, one is in the stalk.

California human cases share two HA mutations relative to "consensus" dairy cattle virus HA: D95G & S336N in H3 numbering (D88G & S320N in H5 numbering; D014G & S336N in sequential numbering). Both these mutations also in some dairy cattle HAs, so not unique to human cases.

Doses of an experimental #Marburg vaccine — designed at the @NIH's Vaccine Research Center & being developed by @sabinvaccine — arrived in Rwanda on Saturday where a clinical trial will soon get underway. Photo: Sabin Institute statnews.com/2024/10/04/mar…

@mvankerkhove of @WHO urging for evidence driven policy, equitable access to safe and effective vaccines, building Pandemic Influenza Preparedness (PIP) strategy, and platforms to facilitate sharing of key reagents

Do we need more women in #pathology mentoring and leadership? Ann Gronowski believes we do, and here’s why 💭 bit.ly/3vuIJYr

An important study by F. Eun-Hyung Lee's team shows that long lived plasma cells (the source of long-term circulating antibodies) fail to establish after mRNA vaccination (even combined with SARS-CoV-2 infection). 🧵 (1/) nature.com/articles/s4159…

Nice article

@jbloom_lab Same glycosylation site as was lost in the two 2012 H5N1 ferret transmission experiments

Adding note that WHO / CDC developing one candidate vaccine virus w A160T (a la A156T, A172T), as described at who.int/publications/m… Their data (below) show this candidate vaccine virus unaffected by A160T mutation, as expected Again, good they are so attentive to this issue

Here is analysis of HA mutations in H5 influenza case in Missouri resident without known contact w animals or raw milk. TLDR: there is one HA mutation that strongly affects antigenicity, and another that merits some further study.

Amazing, quick work! Would like to hear what is happening in NA/2SBS also. A160T restores a glycosylation site that could affect HA:NA balance e.g. doi.org/10.1371/journa…

Picked up via routine national influenza surveillance 💪

Why are some people volunteering to be infected with diseases? Dr @anikasinga from @ImperialInfect shares preliminary insights and findings on the SARS-CoV-2 human challenge study with @BBCNews #COVID19 bbc.com/future/article…

Clinicians detail H5N1 infections in 2 Michigan farm workers One patient had conjunctivitis in one eye, and the other had longer lasting flulike symptoms. ow.ly/laZi50SUc1Y

MSC has published its findings on the 2023 clinical academic survey, revealing an ageing workforce and continuing gender and ethnic imbalances in clinical academia. Press release: bit.ly/3vGqZJU Interactive tool: bit.ly/3JsxwMM

3rd US #H5N1 #birdflu case, this one with respiratory symptoms. Farm worker in Michigan who wasn't wearing PPE. Said to be recovering. statnews.com/2024/05/30/bir…

Agree with all of this - great article in @NatureMedicine - "Why diversity is needed at every level of clinical trials, from participants to leaders" nature.com/articles/s4159…

To further protect the U.S. livestock industry from the threat posed by highly pathogenic H5N1 avian influenza, @USDA is sharing a number of actions that we are taking with our federal partners to help us get ahead of this disease and limit its spread. usda.gov/media/press-re…