Ankush Sharma

@vfsglobalcare Dear @vfsglobalcare care to reply after 2 days ??

Dear Ankush, we understand your concern and are committed to helping you. Please DM us your full name, contact number(s), email address, the country you will be visiting, and the location of the Visa Application Center you plan to visit and the appointment reference number for us to assist you further.

.@MEABharat Why renewal of passports in Australia takes time that too more than 3 months ? Posting on behalf of a friend ! @VFSGlobal takes more than a month to forward the applications !! Its high level of incompetence and brings more uncertainty for travel plans !

@nopra_shant Can everyone get a connection in @MEABharat @HCICanberra ??

@sardesairajdeep @sanjaymanjrekar Reverse hypothetically ! No T20 worldcup for India , then you would hv thouht the same way , start giving credit to yourselves , you are living in much better India than you were grown into . Its not just cricket !

I agree and disagree with my old Bombay univ winning captain @sanjaymanjrekar . I agree: a 50 over World Cup win is like winning the soccer World Cup every four years which is why for me, nothing will match 1983 and Dhoni’s 2011 six . Can’t have the T 20 cycle every two years: that devalues a ‘World’ title. I disagree that T 20 wins don’t come ‘remotely close’: T 20 is flavour of gen next and a repeat win is remarkable. BUT, yes, for me, winning a 50 over World Cup is still the ultimate. As it is I am sure for most genuine cricket fans. (WTC also is very special but don’t agree with how points are counted). In my book 1) 50 overs World Cup 2) WTC 3) World T 20 (don’t call it a World Cup ) 4) Champions Trophy

@sardesairajdeep @sanjaymanjrekar It is just that Having things in abundance often feels unimportant because human psychology is wired to assign value based on scarcity, utility, and novelty! Your mentality is getting shaped like this coz India is now winning more frequent as opposed to your times …

More evidence that #immunotherapy works better in the morning. In a prospective, randomized phase III trial, giving first-line chemo-immunotherapy earlier in the day (<15:00) nearly doubled PFS (11.3 vs 5.7 mo, HR 0.40) and improved OS (28.0 vs 16.8 mo; HR 0.42) in advanced NSCLC. More effective, no added cost and easy to implement. Likely reflects circadian immune rhythms with greater CD8⁺ activation and less T-cell exhaustion. doi.org/10.1038/s41591… @OncoAlert

@aiims_newdelhi The link attached points to story of miley brown

Dr. Hitender Gautam, Professor of Microbiology, AIIMS New Delhi, explains how antimicrobial resistance (AMR) spreads, the challenges doctors face, and steps to tackle the problem at hand. Read more: timesofindia.indiatimes.com/life-style/hea… #AIIMSAMRAwareness

@airindia Indeed they are without the policies or knowhow what to do ! Whats the solution for travelers traveling zurich - delhi - udaipur. ( with infant ) and how much time one should take to resolve the problem ?

Dear Mr. Sharma, we understand that disruptions are never ideal. The flight schedule has been impacted due to poor visibility caused by dense fog in Delhi this morning. Our ground teams at the airport are trying their best to get you to the destination and working round the clock to assist you.

#TravelAdvisory Poor visibility due to dense fog in Delhi this morning has impacted flight operations for all airlines. We are closely monitoring conditions and will resume operations as soon as it is safe to do so. In the interest of safety, and to avoid prolonged uncertainty for our guests, some flights have been cancelled. We understand this may cause inconvenience, and our ground teams across airports are working round the clock to assist and support you. We request guests to check their latest flight status at airindia.com/in/en/manage/f… before proceeding to the airport. Thank you for your patience and understanding during this situation. Flights cancelled so far: •AI2767 / 2768 •AI1787 / 1872 •AI1721 / 1837 •AI1701 / 1806 •AI1725 / 1860 •AI1745 / 1890 •AI1797 / 1838 •AI1703 / 1884 •AI2653 / 2808 •AI2469 / 2470 •AI866 •AI1737 / 1820 •AI1719 / 1844 •AI1785 / 1851 •AI2495 / 2496 •AI1715 / 1816 •AI3313 / 3314 •AI881 / 882 •AI2465 / 2880

The implications of these PFS data are huge given this was time limited therapy. If in remission around 1 year, you probably have at least a 50/50 chance of remaining in remission 4 years later off therapy! If this is what we see in 3L+, could anti-CD3xCD20 BsAbs be curative therapies for FL?

Yup, I'm aware :) And also, for comparison: ashpublications.org/blood/article/…

CRC before 50 isn’t just early - it’s different at the core 🧬🔥 📊 Large NGS study (n=1209; 4 Italian centers): • EO-CRC (≤50y; n=298) vs AO-CRC (n=911) • Profiling with FoundationOne CDx (324 genes) 🔍 Molecular fingerprints in EO-CRC: 📈 Amplifications: MYC, RAD21, GNAS, MAPK1 ❌ Loss: CDKN2B 🧪 Mutations: APC R876*, NRAS Q61L, PIK3CA E545K, TP53 G266V ⏳ Survival impact (PSM analysis): 📉 OS → 35 vs 41 mo (P=0.0326) 💪 ECOG 0 → 35 vs 44 mo (P=0.0026) ⚡ RAS/BRAF-mut → 27 vs 44 mo (P=0.0024) ⚖️ Take-home: EO-CRC is biologically distinct, molecularly aggressive, and demands age-tailored strategies. Pretta et al. ESMO Open 2025. DOI: doi.org/10.1016/j.esmo… #ColorectalCancer #OncoTwitter #MedTwitter @OncoAlert @oncodaily @asco @esmo @myesmo

Not just coffee - even pembrolizumab works better before 11 AM ☕💉 📊 Eur J Cancer 2025 | 9-center retrospective | n=450 1L Pembrolizumab monotherapy in advanced NSCLC Timing groups: 🌅 Early ≤11:00 AM 🌙 Late >11:00 AM Results (PSM, n=206 | median f/u 62.5 mo): •OS: 43.7 vs 32.4 mo ➝ HR 0.67 (95% CI 0.46–0.97, p=0.03) ✅ •PFS: 13.8 vs 11.6 mo ➝ NS (HR 0.80) •irAEs ≥G3: 26.2% vs 13.6% (p=0.04) ⚠️ ✨ Take-home: First-dose timing may prime immune activation. Morning infusion → better OS, but higher severe irAEs. A simple, low-cost tweak worth prospective testing. 🔗 Eur J Cancer 2025 DOI: 10.1016/j.ejca.2025.115748 Full text: ejcancer.com/article/S0959-… #LungCancer #Immunotherapy #Chronotherapy #OncoTwitter @OncoAlert @OncoDailyNet @oncodaily @myesmo @asco

Nature methods: Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues nature.com/articles/s4159…

🧵🧵 Daratumumab-based triplets in RRMM: Real-world DPd vs DKd outcomes @USMIRCNEWS #USMIRC 1/ 💉 Study design: Multicenter retrospective analysis (n=399) of RRMM patients: •DPd = Dara + Pomalidomide + Dex (n=295) •DKd = Dara + Carfilzomib + Dex (n=104) Goal 👉 compare efficacy & safety outside trial setting. #ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوما

Rx of unfit patients with AML: Keeping up with the recent advances #amlsm nature.com/articles/s4140…

Academic medicine is bleeding talent. The best experts are counting to retire or switch careers at an alarming rate. It’s folly to think that you can replace top talent easily — you will need 10 people to provide the level of productivity of one top talent. The effects may not seem obvious. Because you seldom miss what you didn’t know you could achieve. But it will happen. In patient care, in research, and in the development of new treatments.

Just out: Current Treatment Algorithm — completely open access — for elderly patients with acute myeloid leukemia. AML. @BloodCancerJnl By @n_gangat @MayoClinic & Dr. Courtney Dinardo @MDAndersonNews Link: nature.com/articles/s4140…

Zincore uses a completely new method to help proteins bind better to DNA. We gave the protein pair the name Zincore because it controls an important group of switches known as ‘zinc fingers.| Science science.org/doi/10.1126/sc…

Two comprehensive reviews on new bispecific antibodies in #lymphoma made pretty and online @Haematologica #lymsm @AdrianMinson @nancybartlettMD