Sachin Mishra

Paused Polymerase synergises with transcription factors and RNA to enhance the transcriptional potential of promoters biorxiv.org/cgi/content/sh… #biorxiv_molbio

1/n: Super excited to present our work! Huge thanks to my PI, @DimpleNotani and all my co-authors: @rajat007_mann, @stupid_scholar and @Tripti2195 and @NCBS_Bangalore

What is the significance of transcription factor binding to regulatory RNA? @DimpleNotani and colleagues @NCBS_Bangalore show that it stabilizes ERα binding to promoters with weak recognition motifs, but also reduces their transcriptional output embopress.org/doi/full/10.10…

New preprint from lab revealing the functional role of histone modification, H3S10p in coating active TADs for their bookmarking in mitosis. Optimal levels of H3S10p ensure promoter closing in mitosis to protect them from over stimulation post mitosis.

I am excited to share our preprint on mitotic H3S10p's role in maintaining the interphase chromatin state of a cell! Check it out… I am thankful to @DimpleNotani @NCBS_Bangalore ;all the authors @arhsimnihcas @ARIFHUSSAI42221 Anurag Kumar Singh @rajat007_mann and Notani Lab

RNA binding limits the ligand induced transcriptional potential of estrogen receptor-alpha biorxiv.org/cgi/content/sh… #bioRxiv