Ashwin Patel

CMS is now paying AI vendors a cut of the care they deny. The FDA just cleared the first AI to detect cardiac amyloidosis from a routine ECG. And a former CEO says health systems must replace "huge numbers" of staff with AI within 5 years. This week's 𝟑, 𝟐, 𝟏: 𝐇𝐞𝐚𝐥𝐭𝐡 𝐀𝐈 𝐁𝐫𝐢𝐞𝐟 breaks it all down ↓

@shivsakhuja goose

Introducing Gooseworks — AI coworkers that can do real GTM work. Over the last few months, we've been obsessed with turning AI into actual coworkers for our team. And it's working. Goose is now our most valuable teammate – it finds high-intent leads, runs outbound campaigns, coordinates with influencers, tracks SEO / AEO and a ton more. Today we're launching this publicly so everyone can create their own AI coworkers. Each coworker (or Goose) has its own computer, filesystem, mailbox, memory, and tools. Goose can work autonomously for hours, communicates over Slack, iMessage, WhatsApp or email, and gets smarter as you give it more context. It's not just a personal assistant — your whole team can talk to Goose from anywhere, and schedule it to run on autopilot. And here's the best part – we've already given Goose 100+ skills and data APIs for GTM work: – map your TAM – search people databases with natural language – find leads from X and LinkedIn posts – monitor intent signals from your ICPs – update your CRM and generate reports – find influencers and run outreach campaigns – track visibility in search and answer engines – connect to all the SaaS tools your business runs on +++ lots more. We also open-sourced every skill as a toolkit you can install directly in Claude Code. Comment "Goose" and follow and I'll send you the install link.

on national doctor's day, i was excited to receive my copy of David Lortscher, MD's new book, "Why Doctors Win." the book tells the stories of luminary physicians many of us have studied for years, from Dr. Bud Rose, Founder of UpToDate to Drs. Leonard Schleifer and George Yancopoulos, Founders of Regeneron. what connects these stories is a pattern I think about constantly: medicine is one of very few disciplines where deep fluency in the 1:1 craft, the irreducible act of caring for a single patient, becomes the foundation for building at 1:many scale. the physician who has sat with diagnostic uncertainty, navigated a broken workflow, or watched a patient fall through the cracks carries embodied knowledge, a form of structural advantage no diligence process or market analysis can reproduce. happy doctor's day, to those at the bedside and those building from it!

@aschwags3 GA

This quarter, I’ve closed multiple $1M+ without a slide deck. I’m using a single AI tool. Today, I want to share it, free. After signing, a prospect asked me how we created the site. They were so wow-ed they wanted it for their own clients. Here’s what floored them: it took a single designer 5 minutes to prompt and launch. The AI chains together 6 key parts of our sales process, turning a 18-page deck into a single, personalized website. When they asked, I gave them this template and workflow. Now I want to share it for free: Follow me + comment “GA” and I’ll DM it.

@hugomercierooo Twin

𝗧𝘄𝗶𝗻 𝗶𝘀 𝗻𝗼𝘄 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝘁𝗼 𝗲𝘃𝗲𝗿𝘆𝗼𝗻𝗲. twin.so We can’t wait to see what you’ll build. 𝗥𝗧 𝗮𝗻𝗱 𝗰𝗼𝗺𝗺𝗲𝗻𝘁 “𝗧𝘄𝗶𝗻” 𝘁𝗼 𝗴𝗲𝘁 𝗳𝗿𝗲𝗲 𝗰𝗿𝗲𝗱𝗶𝘁𝘀 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗗𝗠𝘀 👇 twitter.com/hugomercierooo…

𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗧𝘄𝗶𝗻 — 𝘁𝗵𝗲 𝗔𝗜 𝗰𝗼𝗺𝗽𝗮𝗻𝘆 𝗯𝘂𝗶𝗹𝗱𝗲𝗿. No setup. Secure. Infinitely scalable. We just raised a $𝟭𝟬𝗠 𝘀𝗲𝗲𝗱. After a beta with 𝟭𝟬𝟬,𝟬𝟬𝟬+ 𝗮𝗴𝗲𝗻𝘁𝘀 𝗱𝗲𝗽𝗹𝗼𝘆𝗲𝗱, we’re now opening to everyone. RT and comment “Twin” — first agents on us. 👇

@Nicolascole77 Books

Amazon banned my book publishing account, so screw it—I'm giving away 2 of my most popular books for free. As of right now: • I have no way to publish on Amazon. • My entire library, thousands of reviews, etc., are all gone. • And I am “banned” from creating a new account on Amazon at any time in the future. I have been publishing non-fiction on Amazon for over 10 years. Sold 40,000+ books. And I was banned because I created a new account to publish my new fiction book under a pen name... Not realizing I should've created that within my existing account. (Oops!) Now, I believe I'll get it back one day. But right now, no one can access my books—so I thought, "Why not give them away for free?" So, if you want a free digital copy of: • The Art & Business of Online Writing • The Art & Business of Ghostwriting Then comment "books" below and I'll DM them to you for free. Inside these books, I explain: • Why you shouldn’t start a blog, how to find your voice as a writer, and the exact steps to build a daily writing habit. • The quickest way to monetize your writing (and get paid to network and learn from industry leaders in your niche). • The secret to making more money as a writer (so you can escape the freelance writer hamster wheel). And tons more! Comment "books" below and I'll DM them to you for free.

@mikefutia VEO 3

You can now create consistent characters with Google Veo 3 videos 🤯 These AG1 ads were created with MY FACE as the spokesperson. This character consistency technique will take any product... And turn it into personalized video ads with lip-sync. Perfect for creative strategists, e-comm brands & ad agencies. Just upload your face and get unlimited spokesperson videos with YOUR consistent character. The best part? Your character stays consistent through zooms → organized by multiple angles, product swaps, voice cloning, & scene variations. Here's what this workflow gives you: → your face as the spokesperson (Higgsfield or Ideogram) → perfect lip-sync with Veo 3 → product swapping with Flux Kontext → custom voice cloning with ElevenLabs Suddenly you're starring in every ad without filming anything. Prediction: we're 3 months away from everyone having AI spokespeople. Start building yours now. Want the full prompts & workflow? Comment "VEO3" + follow and I'll send it over (must be following so I can DM)

Full read in The Atlantic: theatlantic.com/ideas/archive/…

↳ Over 1 in 4 kids aren’t allowed to play unsupervised—even in their own front yard! In real life: kids are fenced in. In a phone: kids are free to roam. More outdoor free play isn't the solution to everything…but locking the front door definitely isn't helping. 🌱

Phones aren't stealing childhoods. But maybe parents are? You've definitely heard something to the effect of: “Kids are glued to their screens—that’s why they don't go outside.” @JonHaidt & team say we’ve got it backwards:

@yashdulla @ycombinator CRM

A few weeks ago the @ycombinator batch begged me to make a CRM crash course for founder-led sales. After multiple drink offers 🍻— I gave in. The session itself went semi-viral inside the batch, and people keep asking for the video. If you’re doing founder-led sales, the CRM might feel like this clunky behemoth system—it doesn’t have to. In the video I go over the absolute basics: → The only 3 CRM objects that REALLY matter (Deals, Contacts, Companies) → CRM best practices → Why logging every interaction isn't optional → How to set up/automate your CRM so it becomes your single source of truth (and sales doesn't hate using it) I wasn’t planning on releasing this outside the YC group, but given the response, happy to share it with others running early sales teams. If you want the video → just comment "CRM" and I’ll DM it to you. Thank you to Aaron Zelinger, @ghita__ha, @Pashpops, @JoshSabol, Thibault Henriet. @NityaArora14, @gunwoo__kim, @adinagoerres for making sure I got this out. This ended up being one of the highest ROI hours I’ve spent lately — founders really need better sales and CRM playbooks. If you’re in the trenches with founder-led sales and figuring this out, happy to help.

The American people should have immediate free access to the science that we so generously fund through the @NIH. Starting today, we do.

The sweet sweet moment you find product market fit (wait for it)

JAMA Psychiatry, 2025: Machine learning is not (yet) ready to predict the onset of schizophrenia or bipolar disorder. Few interesting points: ✅ (1) Schizophrenia prediction outperformed bipolar prediction. Why? Schizophrenia onset is often much more uniform, while bipolar onset is more heterogeneous, making ML's job that much harder. ✅ (2) Only routine EMR data was used; no new data was collected. Interestingly, only the free-text had predictive value. Including the structured data did not make any meaningful improvement. ✅ (3) Positive predictive value (PPV) was too low, across the board. Even though the model showed good discriminatory power for identifying potential cases of schizophrenia (AUROC = 0.80), it wasn’t very good at being right when it made a positive prediction (PPV only 10.8%). This highlights a common challenge in low-prevalence conditions—high false positives despite good overall discrimination. Much more wood to chop here! ## 📚 TL;DR: Earlier diagnosis is critical. But ML is not ready for this yet. We need more data, better models and more computation horsepower. And with the rapid pace of improvements on all of these fronts, I have no doubt we'll see this solved, soon! ##

Experienced the future of self-driving this morning…with @Waymo + great music 🎶

India is a tremendous healthcare market where need >> >supply, but penetrating this market requires truly appreciating what makes it different. Great breakdown of important differences ⤵️