Breton Asken

👀 Looking for a #DataManager 💻 to join the @UCSFmac Genetics 🧬 and Biospecimens 🧪 Program! If you want to be part of the #AD #FTLD research world by helping provide biospecimens and data to researchers world-wide in a collaborative fashion ➡️ tiny.ucsf.edu/DataManager

Multi-Modal Biomarkers of Repetitive Head Impacts & Traumatic Encephalopathy Syndrome: A CPC Series. bit.ly/38zyFlL @BAsken8 @kbcasaletto @mundada_nidhi @CorrinaFonseca @leoiacca @relajoie @tntt32 @ranjani_ps @raquel_gardner @SalvoSpinaSF @grinberg_t @RabLab_UCSF

@riemannsurface1 @MichaelOkun Yes the operationalization of “substantial” remains a work in progress. Right now, the criteria specify one example as 5+ years of American football participation. Such cutoffs have not yet been proposed for other sports or exposure types, nor for number of symptomatic events.

@riemannsurface1 @MichaelOkun “Substantial” refers to the amount/duration of exposure to repetitive impacts, not the severity or magnitude of any given impact. TES research criteria require that someone has a history of substantial repetitive head impact exposure (see Katz et al 2021 for details).

Time to change your slides for students and families. Parkinson’s disease + history of head trauma (risk factor) vs Traumatic Encephalopathy Syndrome (TES). Lot of discussion this week about retiring the terms punch drunk and dementia pugilistica. Thanks @BAsken8 for teaming up.

Combined Effects of Synaptic and Axonal Integrity on Longitudinal Gray Matter Atrophy in Cognitively Unimpaired Adults. Axonal and synaptic biomarkers may improve detection of neural changes. bit.ly/3ERPgyK @CorrinaFonseca @EmilyPaolillo @BAsken8 @ninadjukic @kbcasaletto

The 6th Annual CTE Conference is this month! Join us virtually on Oct. 27 and learn about all the current updates in #CTE research. Register now: bit.ly/3OSX6dH Visit cteconference.com for more information.

Younes et al. show that right-predominant anterior temporal lobe degeneration is characterized by a progressive decline in semantic knowledge for socioemotionally relevant concepts, and propose that it should be named ‘semantic behavioural variant FTD’. bit.ly/3bvnmMy

@ConcussionUd @DocHerceg I found this @alzforum article and the expert commentary to be helpful for contextualizing the story and the ultimate ramifications of the potentially doctored results. alzforum.org/news/community…

@DocHerceg Absolutely devastating story if true. Punishment needs to be drastic if they mislead AD research for 15 years based on falsified data/images.

Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease. Findings support tau PET as a biomarker that captures both the clinical severity and molecular pathology specific to AD. bit.ly/3yXs25E Jeremy A Tanner @RabLab_UCSF

Tanner et al. show that tau and neurodegeneration, but not amyloid, are similarly associated with cognition in both early and late-onset Alzheimer’s disease. bit.ly/3AhL0GI

Plasma P-tau181 & P-tau217 in Patients w/ Traumatic Encephalopathy Syndrome with & w/out Evidence of Alzheimer Disease Pathology. Feasible/scalable biomarker. bit.ly/3asdT82 @BAsken8 @kbcasaletto @relajoie @leoiacca @JulioCRojas10 @raquel_gardner @grinberg_t @RabLab_UCSF

Multimodal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinico-Pathological Case Series. 9 patients with prior repetitive head impacts (RHI) classified retrospectively using the TES research framework. bit.ly/38zyFlL @BAsken8

NOW ENROLLING: Project S.A.V.E. We're looking for former male & female contact sport athletes age 50+. Results could inform strategies to treat & prevent symptoms associated w/head impacts from contact sports. Study sites @BUMedicine & @UCSFmac. #recruitment

Annual teddy bear toss has to be in the running for coolest sports traditions ever. Gets better every year.

🎉New 2-year #postdoc opportunity with @raquel_gardner @KristineYaffe for researchers in #TBI and #aging! Learn more here: tinyurl.com/ycktjr87 #epitwitter #AcademicChatter

And we are especially excited to celebrate our new #BMBH Conference Fellows who will be receiving mentorship & support for community-based research in #cogaging w/in the Black community! Let’s go!!🎊👏🏽@willmcbride_phd @MrYatesB @_LilBucket @Dkesiaka @victorekuta @casey_laduke

The @UCSFmac is offering 4 Neuropsychology Postdoctoral Fellowship positions for 2022–2024. See and share the announcement below for research opportunities. @kbcasaletto @relajoie @PossinKate @ElenaTsoy @BAsken8 @INSneuro @TheAACN

The Black Men's Brain Health (BMBH) Conference during 2022 Super Bowl week aims to convene academics and community leaders to increase the representation of Black men in brain science research and to reduce brain health disparities among Black men. mensbrainhealth.org

@Concussion_Pro @WillStewNeuro I’ve had papers inaccurately cited before, but that one is a doozy.

Except there is no evidence at all to support either of those as a risk factor for CTE

Controversy and Progress in Alzheimer’s Disease — FDA Approval of Aducanumab. Dr. Gil Rabinovici provides his perspective on this pivotal and controversial point in Alzheimer’s disease treatment. bit.ly/2Wr4l69 @RabLab_UCSF @ucsfhealth @NEJM