Lydia Freddolino

Exciting news – we’re hiring! Join our vibrant community, explore new frontiers in biochemistry, and mentor the next generation of scientific leaders. For more information and application link see medschool.umich.edu/sites/default/… @UMich, @UMichMedicine, #UMichBiolChem

Our department (Biological Chemistry at the University of Michigan; #UMichBiolChem) is hiring! Details at medschool.umich.edu/sites/default/… -- we're looking for faculty at all ranks, and the department is really interested in further expanding our capabilities in computational biology.

Join the cutting edge of biochemistry - apply to University of Michigan Biological Chemistry’s PhD program! medicine.umich.edu/medschool/educ… Great people, great science, great careers. Applications accepted through Dec 1.

Come see us at #BPS2023! Peter will be presenting on large-scale structure/function predictions for annotating microbial proteomes (Room 5AB, 11:30 am today) and Ali will present on multiscale modeling of heterochromatin formation in fission yeast (Wednesday poster session, B169)

@AlbertVilella (Also, there was still substantive progress in the single chain predictions this year relative to CASP14, contrasting top groups this year to the vanilla AF2 and ColabFold predictions... as noted in the Rigden et al. slides, the targets this time were probably harder)

Slides of the different #CASP15 presentations available for download. Slide below shows how #CASP14 (black line) was truly the renaissance moment of protein folding

@AlbertVilella Interesting to compare with the plot from @Ezgi_Karaca_ showing the same sort of curves for multimer predictions, where we saw a big jump from CASP14 to CASP15

@EvolvingVir @FreddolinoLab Monomer predictions are D-I-TASSER (I-TASSER replica exchange simulations guided by threading and deep learning based potentials), multimeric are DeepMSAFold-multimer (extended MSAs guiding AlphaFold2-multimer). Papers coming soon. Slides at predictioncenter.org/casp15/doc/pre…

@FreddolinoLab Is somehow implemented in Cosmic HPCC ?

Happy to share that our Michigan #CASP15 team ended up placing second in Regular Targets, first in Multimeric Targets, and first in Inter-domain prediction (1/3)

It's finally time to discuss the main highlights of #CASP15's assembly category, where we had these beatiful 41 targets: