Pamela Munster

@SidYadavMD @Nature That is great work

A dream come true- published in @Nature Using CRISPR–Cas9, we analyzed the functional effect of >6500 missense Variants of Uncertain Signficance (VUS) lBRCA2, and reclassified >90% of variants as pathogenic, likely pathogenic, benign, or likely benign. This work changes the landscape of VUS in BRCA2, providing clinically actionable results to patients to guide risk management strategies or treatment with targeted therapies such as PARP inhibitors. I am immensely grateful to my mentor, Dr. Fergus Couch, for this opportunity, and many thanks to @ConquerCancerFd , Mayo Clinic K12 grant, Halt Cancer at X and @MayoCancerCare Breast and Ovarian SPORE for supporting my work. Link to the article (Open Access): nature.com/articles/s4158… Press release from Mayo Clinic: newsnetwork.mayoclinic.org/discussion/res…

@stolaney1 @elmayermd @OncoAlert @DFCI_BreastOnc @Nikhilwagle @Merregan Interesting study, and the PFS for fulvestrant alone looks a lot longer than in other oral SERD studies

Beautiful presentation by @elmayermd of the PACE trial looking to address continuation of palbociclib beyond progression on prior CDK 4/6i No improvement in PFS seen: 4.6 mo vs 4.8 mo Interesting signal for fulvestrant + palbo + avelumab (PFS 8.1 mo) @OncoAlert #bcsm #SABCS22

@EricTopol Interesting except that there are two concerns for the breast oncologist: 1) an imbalance of TNBC (22 vs 11 with an expected higher response) in the FMD group and the sentence in the text that PCR was not different for either group. The latter is what really matters.

6. The potential for fasting to favorably modulate the course of cancer in a randomized trial of 131 patients with breast cancer nature.com/articles/s4146…

Switching gears from covid-centric to #cancer, where there have been a flurry of important papers in the past week 1. "Our discovery of #lesionsegregation challenges longstanding assumptions of cancer evolution" nature.com/articles/s4158… @nature media.nature.com/original/magaz… @NatureNews

@sanmateoco @SMCSheriff With great sadness

San Mateo Countywide curfew is in effect today June 2 and June 3 at 8:30 PM to 5:00 AM to protect residents, prevent looting. Please note: Some cities may set stricter curfews based on their local needs. Visit smcgov.org for more information.

lecture.ucsf.edu/ets/Play/8924f… talking to patients about BRCA mutations

An Oncologist Shares Her Personal Story About BRCA | Bottom Line Inc bottomlineinc.com/health/breast-… via @BottomLine_Inc

@UCSFCancer exited to co-host with Michelle Arkin and Charly Craik NCI Chemical Biology Consortium

@hoperugo Well deserved Laura

@OncoBioMed @ad1600 A testimonial of persistence this trial was long in the making

Honoring my friend and breast cancer survivor Lis

Coming back from the Diller Cancer Center retreat: A lot of great research is happening at UCSF