biobrain
2.4K posts
biobrain
@biobrainbox
Lapsed Liverpudlian & former Neuroscientist. Rare disease and Neurology expertise plus CDMO insight. Interested in the intangibles of R&D success.
Katılım Aralık 2021
563 Takip Edilen451 Takipçiler
בטעות קראתי השם של תרופה הזאת וחשבתי זה אמר ״Aliyah" 😭😭😭
Bruce Booth@LifeSciVC
Congrats to Denali for their FDA Approval of AVLAYAH! Fun bit of biotech history. The bi-specific shuttle technology used in Avlayah came from F-star, a European biotech we helped seed in 2006 (thx Regina Hodits). They were advancing a bi-specific mAb format for a range of uses. Image below is from their 2006 pitch to us. F-star did a collaboration with Denali to use their "Fcab" technology for BBB shuttles in 2016, when the now 10-year old biotech was figuring out what programs to advance internally vs in collaboration nature.com/articles/d4374… In 2018, seeing momentum in their BBB programs, Denali acquired the subsidiary housing the BBB technology, called F-star Gamma. fiercebiotech.com/biotech/denali… With the approval of Avlayah, F-star's original technology thesis finally made it to market for one of the many postulated uses... 20 years later... Atlas Fund VII, a 2005 vintage fund, will be getting a small but fun milestone payment for approval... Biotech is a long game, played by teams across the ecosystem collaborating in different ways over decades. Huge kudos to Ryan Watts, @rtnarch, and the team at Denali for their persistence in pushing Avlayah forward to patients.
עברית
I can't believe Shelley got away with this for as long as she did.
Benji@WrnrWrites
To confirm, this “100% AI generated” passage is the opening of chapter 5 from Mary Shelley’s Frankenstein
English
Curious what the diplomatic landscape looks like after this war. The Gulfies can thank Israel or try to blame it.
Nick Schifrin@nickschifrin
In @CENTCOM Commander Adm. Cooper's first interview since the Iran war, on @IranIntl_En, Cooper confirms that Israel is helping defend the Gulf: "Israel is attacking drones and ballistic missiles that are aimed at Arab countries, attacking and defeating them."
English
@FraserNelson Which in turn suggests she doesn't understand how markets work.
English
Significant story. Suggests a Rayner premiership would use OBR criticism to do more borrow and spend - on grounds that it would pay for itself.
Problem is that no other forecaster sees it her way. Nor would the markets
Steven Swinford@Steven_Swinford
Exclusive from @breeallegretti Angela Rayner has privately criticised the OBR and suggested that Labour has 'over-corrected' in the wake of the Tories In a private call with City investors organised by BNP Paribas she said that the official forecaster had failed to recognise the benefits of increased public spending Rayner attacked the scoring methodology used by the OBR, which measures the expected cost and growth gains of government policies to calculate the amount of fiscal headroom, based on the chancellor’s rules She said that the government's drive to build more social housing was considered a cost without any recognition of the social benefits She argued that the OBR is 'preventing' the government from greater public spending because it 'doesn't account for the returns' properly Expect this to be a growing fault line as the elections in May approach thetimes.com/uk/politics/ar…
English
@ideapharma Feels like the tagline has been written by committee (the CFO insisted on the last part)
English
@BursatilBiotech I'm suggesting that earlier delegation may have been a better option for the monarchy but the current monarch is not exactly free of baggage.
English
@biobrainbox You mean his grandsons or son? I can’t think of such a take over w/o the royalty being involved. It strikes me every time to think about how the uk was while the queen was still alive vs today. Im happy I was able to get teddy bear as the v last piece back in ‘19 when I was there
English
Hasta hace unos pocos años, Inglaterra todavía era esto.
Nada, pero absolutamente nada de lo q vemos ahora sería posible sin la complicidad de la realeza y el gob. El país estaba en juego y ella lo sabía, por eso no delegó nada hasta su muerte.
Michael Cowan@mrmikecowan
This on par if not better than the Olympic James Bond scene. The Queen having tea with Paddington - incredible that at 96 and after 70 years on the throne she still has the power to surprise #platinumpartyatthepalace
Español
If modernity has proven one thing about human nature it's that our sense of prosperity is relative. You can be 100 times better off than the average person a generation or two earlier, but if your neighbour seems to have a better life you will feel hard done by.
Paul Heron@Paul_Heron_
If high income is universal no one has high income.
English
Reminder: this is related to why Britain’s Royal Navy has nearly disappeared
The sun has set on 🇬🇧
GB News@GBNEWS
Winston Churchill to be scrapped from banknotes as Bank of England outlines 'overdue' decision gbnews.com/money/bank-of-…
English
@AAMortazavi The Mullah rationale was to arm and strengthen their proxies and let them fight Israel while supporting China against the US.
English
I loathe these mullahs but I don’t believe they were going to attack either the US or Israel first…
English
@CAMERAorgUK @FT He's very much an establishment man. Little sense of originality.
English
I'm always surprised CAR-T therapy doesn't make it onto lists of Israeli inventions!
It was developed by Zelig Eshhar at the Weizmann Institute back in 1989
Yoni Leviatan@songsofyoni
Beauty is in the eye of the beholder, so I won't try to negate Tucker's opinion of the country where all these things were built since 1948: Cell phones Instant messenger USB drives Thunderbolt Face ID Voicemail Digital printing Waze navigation Iron Dome Camera pills Cherry tomatoes Drip irrigation Desalination Water out of thin air for the thirsty to drink Exoskeleten for paralyzed people to walk AI cam for the blind to see The microprocessor that powered the first PC, the ancestor of all PCs today And lots more including the discovery of THC in 1967 (it was a big year). Israel also has lots of natural beauty, much of it ancient like the country, built by our ancestors thousands of years ago when we first inhabited the land of the bible. But again, beauty is in the eye of the beholder – what is not, is the contributions Israelis have made to the modern world. Almost everything you use in your daily lives has an Israeli signature on it. Our buildings may very well be uglier than those in Qatar where Tucker gets his checks signed, but if so, that's because we value things that provide utility to the world and that is where we focus our efforts. I'll take a cellphone with voicemail, instant messaging, Waze and Face ID over a tall generic building any day of the week. Meanwhile, if you want to see some of the most beautiful sites in the world, book a ticket to Israel after the war ends. I promise it'll be safer than ever.
English
Revolutions are impossible before they happen and inevitable after they happen.
English
Have any soccer fans in my stream supported an EPL team that was relegated? What was that like?
Asking as a humiliated, angry Spurs fan...
English
@wessiedutoit Don't need to rush but do need to be competent. Failed on the latter.
English
I agree with Aris. Much to criticise in Starmer's handling of events but the idea that we should rush to join this reckless and seemingly aimless war is crazy.
Aris Roussinos@arisroussinos
I dislike Starmer intensely, but he is here entirely correct, and the British Right, particularly Reform, almost entirely, catastrophically wrong
English
Top UK Royal Navy Admiral claims that training and soft partnership support is better for Middle East allies than warships.
And they wonder why @SecWar didn’t want their help.
English
It's an interesting debate to be had if mining and biotechs are some of the most *similar* sectors in important ways!
Lord_of_Biotechs@Lord_of_Biotech
$KLTO - Sounds perfect... Biotech and mining ... I could not imagine a better operative fit. So much synergies!
English